A5018738108- COVID-19 Clinical Research Studies
- Pancreatic function and diabetes
- Dysphagia Assessment and Management
- Parkinson's Disease Mechanisms and Treatments
- Child Nutrition and Feeding Issues
- Radiation Dose and Imaging
- Radiology practices and education
- Clinical Nutrition and Gastroenterology
- Long-Term Effects of COVID-19
- Health Systems, Economic Evaluations, Quality of Life
- SARS-CoV-2 and COVID-19 Research
- Healthcare cost, quality, practices
- Metabolism, Diabetes, and Cancer
- Advances in Oncology and Radiotherapy
- Cancer, Hypoxia, and Metabolism
- Intensive Care Unit Cognitive Disorders
- Neuroendocrine Tumor Research Advances
- Pacific and Southeast Asian Studies
- Diabetes Treatment and Management
- Healthcare Policy and Management
- Diabetes and associated disorders
- Adrenal and Paraganglionic Tumors
- Parkinson's Disease and Spinal Disorders
- Venous Thromboembolism Diagnosis and Management
- Older Adults Driving Studies
Royal Derby Hospital
2002-2024
University Hospitals of Derby and Burton NHS Foundation Trust
2019-2024
British Geriatrics Society
2021
University of Dundee
2021
Medical Research Council
2021
Oxford University Clinical Research Unit
2021
Public Health Scotland
2021
National Health and Medical Research Council
2021
Intensive Care National Audit & Research Centre
2021
NIHR Clinical Research Network
2021
The pancreatic beta cell normally maintains a stable balance among insulin secretion, production, and degradation to keep optimal intracellular stores of the hormone. Elevated levels FFA markedly enhance secretion; however, effects on production remain unclear. In this study, twofold elevation in total circulating effected by infusion lard oil heparin into rats for 6 h under normoglycemic conditions resulted marked evident after 4 h, 30% decrease content 6-h vivo. Adding 125 muM oleate...
Phaeochromocytomas and paragangliomas are familial in up to 25% of cases can result from succinate dehydrogenase (SDH) gene mutations. The aim this study was describe the clinical manifestations subjects with SDH-B mutations.Retrospective case-series.Thirty-two mutations followed between 1975 2007. Mean follow-up 5.8 years (SD 7.4, range 0-31). Patients seen at St Bartholomew's Hospital, London other UK centres.Features presentation, genetic mutations, tumour location, catecholamine...
In the short term (< 2 h), proinsulin biosynthesis is predominately glucose regulated at translational level; however, details molecular level behind this mechanism are not well defined. One of major hindrances for gaining a better understanding biosynthetic has been lack an abundant source β-cells that express phenotype in appropriate 2.8–16.7 mmol/l range as defined normal pancreatic islets. study, we demonstrate MIN6 cell line, specific glucose-regulated control present...
Transgenic nonobese diabetic mice were created in which insulin expression was targeted to proopiomelanocortin-expressing pituitary cells. Proopiomelanocortin-expressing intermediate lobe cells efficiently secrete fully processed, mature via a regulated secretory pathway, similar islet beta However, contrast the insulin-producing cells, pituitaries are not or destroyed by of immune system. Transplantation transgenic tissues into resulted restoration near-normoglycemia and reversal symptoms....
The regulation of proinsulin biosynthesis in pancreatic β-cells is vital for maintaining optimal insulin stores glucose-induced release. majority nutrient fuels that induce release also stimulate biosynthesis, but since exocytosis and synthesis involve different cellular mechanisms, a point divergence the respective metabolic stimulus–response coupling pathways must exist. A parallel examination secretion was undertaken same β-cells. In MIN6 cells, shared requirement glycolysis to generate...
ObjectiveSuboptimal management of Parkinson's disease (PD) medication in hospital may lead to avoidable complications. We introduced an in-patient PD unit for those admitted urgently with general medical problems. explored the effect on management, length stay and patient experience.MethodsWe conducted a single-center prospective feasibility study. The unit's core features were defined following consultation patients professionals: specially trained staff, ready availability drugs,...
Mutations in succinate dehydrogense-B (SDHB) and the von Hippel-Lindau (VHL) genes result an increased risk of developing chromaffin tumours via a common aetiological pathway. The aim present retrospective study was to compare clinical phenotypes disease subjects as SDHB mutations or VHL disease. Thirty-one with were assessed; 16 had gene 15 diagnosis VHL. VHL-related predominantly adrenal phaeochromocytomas (22/26; 84.6%), while SDHB-related extra-adrenal paragangliomas (19/25; 76%). Median...
ABSTRACT Background Percutaneous endoscopic gastrostomy (PEG) can facilitate feeding and medication administration in dysphagic patients with Parkinson's disease related disorders. Information on survival, institutionalization, complications post PEG might inform decisions. Method A total of 93 disorders were identified by review registers searching the administrative databases 2 large UK university hospitals (2005–2017); 83 case notes available for retrospective review. Care processes...
Abstract There is increasing evidence that the effective care of patients with Parkinson's disease should involve a multidisciplinary team health professionals, including neurologist or geriatrician, nurse specialist, physiotherapist, occupational therapist, speech and language dietitian, clinical psychologist social worker, among others. Here, authors review for efficacy multi‐disciplinary working describe their own model in Derby.
<h3>ABSTRACT</h3> Providing feedback on cost has been demonstrated to decrease drug demand from clinicians. We conducted a prospective study with step-wise intervention test the hypothesis that providing information of drugs clinicians would modify total expenditure. Participants included individuals who were admitted Royal Derby Hospital November 2013 November 2015 under care physicians. The all antibiotics and inhaled corticosteroids was added electronic prescribing system. main outcome...
<h3>ABSTRACT</h3> Computed tomography (CT) is readily available in developed countries. As one of the side effects includes an increased risk cancer, interventions that may encourage more judicious use CT are important. Behavioural economics theory nudges aim to help informed decisions be made, although these have been rarely used hospitals date. We aimed evaluate impact a simple educational message appended report on subsequent numbers completed using controlled interrupted time series...
Punctual delivery of dopaminergic medication to Parkinson's disease (PD) patients may be important in optimizing control. We tested the hypothesis that prompt l-dopa medications emergency hospital inpatients was associated with a decreased length stay hospital.The study population consisted all urgent hospitalizations for diagnosis PD Royal Derby Hospital over two-year period. Data were extracted on timing drugs, number co-morbidities and stay. Statistical analysis used linear regression...
We have studied the expression of pituitary transcription factors Ptx-1 and Prop-1 in a series 34 adenomas fully characterized for vitro hormone secretion histological staining. In studies involving mammalian cell lines, factor has been shown to be panactivator, whereas more recent that it plays an important role α-subunit gene expression. Its not examined previously human by secretory profiles. Of studied, was reduced than 50% compared housekeeping glyceraldehyde-3-phosphate dehydrogenase 6...
In this study, we examined whether adenoviral-mediated glycerol kinase (AdV-CMV-GlyK) expression in isolated rat pancreatic islets could introduce glycerol-induced proinsulin biosynthesis. AdV-CMV-GlyK–infected islets, specific biosynthesis translation and insulin secretion were observed parallel from the same islets. The threshold concentration of required to stimulate was lower (0.25–0.5 mmol/l) than that for (1.0–1.5 mmol/l), reminiscent differences glucose-stimulated versus secretion....
Abstract Background In the context of increasing availability computed tomography (CT) scans, judicious use ionising radiation is a priority to minimise risk future health problems. Hence, education clinicians on risks and benefits CT scans in management patients important. Methods An educational message about associated lifetime cancer scan was added all reports at busy acute teaching hospital UK. online multiple choice survey completed by doctors before after intervention, assessing...
Parkinson's disease (PD) is the most common movement disorder in elderly and characterised clinically by bradykinesia, tremor rigidity. Diagnosing can be difficult especially early stages. High-resolution nigrosome MRI offers promising diagnostic accuracy of patients with established clinical symptoms; however, it unclear whether this may help to establish diagnosis stages PD, when there uncertainty. In scenario, a single photon emission CT scan using radioactive dopamine transporter ligand...
To guide decision-making about driving ability, some patients with Parkinson's disease (PD) undergo specialist assessment. However, decisions safety in most need to be made without this definitive test. There is no consensus on what predicts unsafe PD nor a validated prediction tool clinician and the refer for further assessment.To describe characteristics of assessed at Driving Mobility Centre investigate factors that predict assessment outcome.Retrospective cohort study between 2012 2016....
There is a need to improve efficiency in healthcare delivery without compromising quality of care. One approach the development and evaluation behavioural strategies reduce unnecessary use common tests. However, there an absence evidence on patient attitudes such approaches Our objective was explore acceptability nudge-type intervention that aimed modify blood test requests by hospital doctors.Single-centre qualitative study.The financial costs tests were presented doctors results reports...