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Background The pathogenesis of Kawasaki disease (KD) is commonly ascribed to an exaggerated immunologic response unidentified environmental or infectious trigger in susceptible children. A comprehensive framework linking epidemiological data and global distribution KD has not yet been proposed. Methods findings Patients with (n = 81) were enrolled within 6 weeks diagnosis along control subjects 87). All completed extensive questionnaire. Geographic localization software characterized the...

Abstract North Atlantic sea surface temperatures experience variability with a periodicity of 60–80 years that is known as the Multidecadal Oscillation (AMO). It has profound imprint on global climate system results in number high value societal impacts. However industrial period, i.e. middle 19th century onwards, contains only two full cycles AMO making it difficult to fully characterize this oscillation and its impact system. As result, there clear need identify paleoclimate records...

Introduction: In mid- to high-latitude regions, cerebrovascular diseases (CBVD) are known peak during the winter. Aside from traditional clinical risk factors, emerging research has documented associations between extreme seasonal climate conditions and CBVD, especially among older male females who vulnerable such environments. Despite growing climate-cerebrovascular literature, there is still a need understand seasonal- sex-specific precipitation CBVD events adults. We hypothesize that will...

Abstract Past research on the relationship between unemployment rates and population health has produced mixed findings. The can be influenced by kinds of outcomes observed, time frame, level geographic aggregation, other factors. Given these findings, there is a need to add our knowledge about how are related. There limited that examines association with both physical mental health, while simultaneously stratifying populations income education levels. Using survey-based self-reported data,...

In recent summers, some populous mid-latitude to high-latitude regions have experienced greater heat intensity, more at night than by day. Such warming has been associated with increased cause-specific adult mortality. Sex-specific and age-specific associations between summer nocturnal surface air temperatures (SAT) cardiovascular disease (CVD) deaths yet be established.A monthly time series analysis (June-July, 2001-2015) was performed on sex-specific CVD in England Wales of adults aged...

Introduction Poor adherence or non-adherence to the prescribed medications among heart failure (HF) patients is a common problem. This leads hospital admission due increased HF exacerbations, reduced physical function, and even death. The study was conducted assess medication level, using Morisky Medication Adherence Scale (MMAS-8), visiting adult cardiology department of tertiary care cardiac center in Karachi. Methods cross-sectional included diagnosed with for follow-up both inpatient...

Objectives: To evaluate the estimates of burden cardiovascular diseases (CVD) in South Asian (SA) region from 1990 to 2019 using Global Burden Disease (GBD) study. Methodology: Data for this ecological study was extracted Health Exchange query tool 30 years 2019. Dataset consisted prevalence, deaths, and disability-adjusted life (DALYs) due CVD summarized as estimated number cases rate per 100 thousand individuals Pakistan, India, Bangladesh, Nepal, Bhutan region. Results: An increasing...

Abstract Ischemic heart disease (IHD) is one of the leading causes death worldwide. While extreme summer surface air temperatures are thought to be a risk factor for IHD, it unclear whether large-scale climate patterns also influence this risk. This multi-national population-based study investigated association between Pacific and Atlantic sea temperature (SST) variability annual acute myocardial infarction (AMI) or IHD event rates among older adults residing in North America United Kingdom....

Children who receive inadequate exposure to sunlight have reduced levels of vitamin D, resulting in rickets, a disease that is characterized by bone deformity, stunted growth, and long term pronounced disability. The United Kingdom rickets incidence rates declined from the early 1960's mid-1990's, after which there was dramatic increase. reason for this change not well understood. Here we show an important low frequency mode climate variability, Atlantic Multidecadal Oscillation (AMO), with...

It is well known that climate variability and trends have an impact on human morbidity mortality, especially during the winter. However, there are only a handful of studies undertaken quantitative investigations into this impact. We evaluate association between UK winter asthma mortality data to well-established feature system, Scandinavian (SCA) pattern.Time series analysis monthly through period January 2001 December 2015 was conducted, where were acquired from UK's Office for National...

Abstract The frequency and magnitude of extreme summer temperature events in the United States have increased past few decades. Long‐term exposure to temperatures can be detrimental human health, due potential risks dehydration thermoregulation strains on cardiovascular system, which may often lead heat‐related mortality (HRM). climate is influenced by variability Atlantic Pacific sea surface temperatures, driven part Multidecadal Oscillation (AMO) El‐Nino Southern (ENSO), respectively....

Background In underdeveloped countries, coronary artery disease (CAD) has developed into a serious health issue due to the high rates of risk factors such as obesity and smoking amongst population. This study been performed find rate multivessel CAD (MVD) subsequent thrombolysis in myocardial infarction (TIMI) flow grade III patients undergoing primary percutaneous intervention (PCI). Methods transverse was carried out involving 110 from emergency department National Institute Cardiovascular...

Objectives: The objective of this study was to determine the 30 years (1990 2019) trends rheumatic heart diseases (RHD) in terms estimated prevalence, deaths, and disability-adjusted life (DALYs) for Pakistan. Methodology: This ecological consisted an analysis data extracted from Global Burden Disease Study, which (from 1990 trend RHD Pakistan DALYs, deaths number cased age-standardized rate (ASR) per 100,000 population. Results: prevalence has shown a 134.1% increase 705,795...

Abstract Ischemic heart disease (IHD) is the leading cause of death worldwide. In United States, IHD deaths affect millions adults, with substantial age and race/ethnic-specific variability. recent years, emphasis has been placed on reducing rate events among middle-aged adults. Non-Hispanic (NH) Black populations are known to have greater mortality rates compared other races/ethnicities. Researchers established several biological, clinical, socioeconomic risk factors, but severe climate...

<title>Abstract</title> North Atlantic hurricanes have intensified in the past decades, resulting excess deaths especially among lower-income populations who tend to elevated mortality rates coastal regions. Yet effects of hurricane intensity on by income and education levels has not been understood. This population-based study used accumulated cyclone energy (ACE) index examine all-cause (20–84 years) county-level college level stratification (high low) southeastern United States from...

Surface air temperature (SAT) and precipitation in Prairie (Western) Maritime (Eastern) Canada are influenced by the El Niño Southern Oscillation (ENSO) Atlantic Multidecadal (AMO), respectively. However effects of ENSO AMO on major crop yield is yet to be understood. Here we investigate longest record (1908–2017) wheat, barley, oat as well its associated risk with summer (May-September) interannual multidecadal variability Maritime, We used generalized linear models autocorrelative...

Background Transradial approach for percutaneous coronary intervention (PCI) is gaining popularity due to lesser bleeding and other access site related complications. This study aims determine the in-hospital outcomes of primary PCI through a transradial in tertiary care cardiac center. Methods Consecutive patients with ST-segment elevation myocardial infarction presenting within 12 hours symptoms without previous history thrombolytic therapy, angioplasty, or surgery were included study. All...