Changes in chemical properties of nanoscale particles include quantum size effect, changes the cell parameters and lattice symmetry, surface interface effects. In case layered double hydroxides (LDHs), effects dominate for nanoparticles MgAl LDHs. Using TEM micrographs nanoparticle-sized LDHs, we have found that increased number atoms relative to internal increases surface-to-surface interparticle attractions. As a result, nanosize LDH are able form continuous oriented films adhere well...

Layered double hydroxide alkoxides obtained by precipitation of MII and MIII salts with NaOH in alcoholic solution have unique properties. They exhibit very large BET surfaces, indicating a pillared structure, their slow hydrolysis yields smooth, almost transparent films the corresponding hydroxides (see Figure for comparison alkoxide-based, left, conventionally produced films, right), high internal order as verified XRD pattern.

Although some novel psychoactive substances (NPS) are newly discovered chemicals, others traditional or indigenous that introduced to new markets. One of these latter is a plant many people refer as kratom. Indigenous Southeast Asia and used for variety instrumental recreational purposes, kratom has recently become available Western drug users. Kratom somewhat unique in the contains two different which have both stimulant (mitragynine) narcotic (7-hydroxymitragynine) properties. Thus, may...

The effect of a number procedures which reduce the energy supply have been tested on various properties auricular muscle. It could be shown that in most instances contractility and spontaneous rate were depressed more than electrical excitability, conduction velocity or effective refractory period. This is marked contrast to effects quinidine where period, excitability sensitive this drug either contractility. The inhibition anaerobic glycolysis muscle was studied it concluded pathway does...

In the past 20 years, ketamine has become a promising treatment for Major Depressive Disorder (MDD) due to its rapid and sustain antidepressant effects in patients. A single causes improvement depressive symptoms within hours can last weeks, long after it is eliminated. Previous studies have demonstrated increased synaptic plasticity at CA3-CA1 synapses hippocampus (HPC) 24 h post suggesting activity-dependent hippocampal function may underlie of ketamine. If true, these changes should also...

5‐(2‐Aminopropyl)benzofuran (5‐APB), a ‘research chemical’ that was first reported by UK authorities to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) in 2010, is anecdotally produce combination of stimulant entactogenic effects. More recently, 2011, 6‐(2‐aminopropyl)benzofuran (6‐APB) identified Hungarian authorities. To confirm positional isomer identity Internet purchased products, 4‐ 5‐ 6‐ 7‐APBs were synthesized found be separable gas chromatography (as...

The effects of various concentrations iodoacetate have been determined on the isolated rabbit auricle. Sinus rate and contractility were functions most sensitive to inhibition. Electrical excitability action potential less affected, refractory period conduction velocity, practically unchanged at a time when had markedly inhibited. temperature, pH medium, stimulation concentration IOA speed determined. substrates such as acetate, pyruvate, lactate, butyrate also demonstrated. Auricles...

1-(Thien-2-yl)-2-methylaminopropane (methiopropamine, MPA), appeared as a 'legal high' in late 2010. It is structurally similar to methamphetamine, with thiophene ring replacing the benzene moiety. Methiopropamine reportedly retains pharmacological properties of amphetamine stimulants, but it does not fall under existing drug laws USA and Ireland. The objective this research was identify pyrolysis products formed conditions that mimic those used by recreational drugs users. Thirteen were...

Abstract Online vendors are offering a new legal high, 4‐methylpentedrone (4‐ MPD ). Information for potential users provided by internet of 4‐ includes incorrect structures and nonexistent CAS numbers. A sample was obtained analyzed using GC ‐ MS , NMR LC EIS . The fragmentation data from the produced an M‐1 ion that suggested molecular mass 219 amu, rather than 205 amu as calculated 4‐methylpentedrone. difference in corresponded to addition methyl group. Based on pattern, two standards...

Three legal highs; nitracaine (3‐(diethylamino)‐2,2‐dimethylpropyl 4‐nitrobenzoate), methoxypiperamide (MEOP, (4‐methoxyphenyl)(4‐methylpiperazin‐1‐yl)methanone) and mephtetramine (MTTA, 2‐((methylamino)methyl)‐3,4‐dihydronaphthalen‐1(2H)‐one) appeared in 2013 as new psychoactive substances (NPS) on Internet websites selling ‘research chemicals’. These compounds were synthesized analyzed via our synthesize, analyze, metabolize (SAM) protocol. Nitracaine was by the transesterification of...

Abstract: The objective of this project was to investigate the trends changes in crystal morphology cocaine presence common adulterants, caffeine and lidocaine HCl. By performing gold chloride microcrystal tests on samples with adulterants at 10, 20, 50% concentrations, can be linked specific concentrations. For cocaine/caffeine mixtures, trend is elongation one axis, additional branching, brown discoloration crystals. At 50:50 branched spherical crystals long needles appear. for...

2‐Amino‐1‐(4‐bromo‐2,5‐dimethoxyphenyl)ethanone hydrochloride ( bk ‐2C‐B) has recently emerged as a new psychoactive substance (NPS). It is most commonly consumed orally, although there are indications that it might also be ingested by inhalation or ‘smoking’. Information about the stability of ‐2C‐B when exposed to heat unavailable and potential for pyrolytic degradation formation unknown substances available prompted an investigation using simulated ‘meth pipe’ scenario. Twelve products...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of soluble uterine cyclic nucleotide phosphodiesteraseE. A. Gardner, W. Joseph Thompson, Samuel J. Strada, and George M. StancelCite this: Biochemistry 1978, 17, 15, 2995–3000Publication Date (Print):July 25, 1978Publication History Published online1 May 2002Published inissue 25 July 1978https://pubs.acs.org/doi/10.1021/bi00608a009https://doi.org/10.1021/bi00608a009research-articleACS PublicationsRequest reuse permissionsArticle...

Background: Online pharmacies have a growing presence. While some are legitimate, others not and may either be scam or provide drugs of uncertain origin, drug type, inconsistent dosing. Some researchers referred to these types as "rogue pharmacies." The purpose this study was order three brand-name black box from suspected rogue pharmacy analyze their contents.Methods: Three were purchased an online pharmacy, "Nolvadex," "ACTOS," "Wellbutrin SR." Piomore, Tamodex, Buprotic SR received. pills...

Brief Report| Online January 01 2000 Supervisory Preparedness of Occupational Therapists Diane G. Johnson; Johnson Johnson, COTA/L, is Student, Master’s in Therapy Program, Lewiston-Auburn College, University Southern Maine, 51 Westminster Street, Lewiston, Maine 04230-3534 Search for other works by this author on: This Site PubMed Google Scholar Lamere-Wallace; Lamere-Wallace Elizabeth A. Gardner Author & Article Information ISSN: 1943-7676 Print 0272-9490 Copyright © the American...