A5100683904- Bone Metabolism and Diseases
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- RNA Interference and Gene Delivery
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Phytoestrogen effects and research
- Congenital Diaphragmatic Hernia Studies
- Receptor Mechanisms and Signaling
- Bone health and treatments
- T-cell and B-cell Immunology
- Protein Kinase Regulation and GTPase Signaling
- Hemoglobinopathies and Related Disorders
- Chemokine receptors and signaling
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Spondyloarthritis Studies and Treatments
- Tendon Structure and Treatment
- Vitamin D Research Studies
- Inflammatory mediators and NSAID effects
- Pharmacological Effects of Medicinal Plants
- TGF-β signaling in diseases
- Reproductive System and Pregnancy
Central Drug Research Institute
2014-2020
University of Illinois Chicago
2020
Council of Scientific and Industrial Research
2014-2017
B.J. Medical College
2015
Govind Ballabh Pant University of Agriculture and Technology
2014
University of Verona
2010
University of Milano-Bicocca
2010
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2005-2006
Activated T cell has a key role in the interaction between bone and immune system. cells produce proinflammatory cytokines, including receptor activator of NF-κB ligand (RANKL), tumor necrosis factor α (TNF-α), interleukin 17 (IL-17), all which augment osteoclastogenesis. RANKL TNF-α are targeted by inhibitors such as denosumab, human monoclonal antibody, infliximab, neutralizes TNF-α. IL-17 is also an important mediator loss, antibody against undergoing phase II clinical trial for...
Abstract IL-18BP is a natural antagonist of pro-inflammatory IL-18 cytokine linked to autoimmune disorders like rheumatoid arthritis. However, its role in post menopausal osteoporosis still unknown. In this study, we investigated the on murine osteoblasts, effect osteoblasts-CD4+ T cells and osteoblasts-CD11b+ macrophage co-culture. mIL-18BPd enhances osteoblast differentiation inhibits activation NLRP3 inflammasome caspase-1 which process active form. Using estrogen deficient mice, also...
We evaluated the bone regeneration and healing effect of Medicarpin (med) in cortical defect model that heals by intramembranous ossification. For study, female Sprague–Dawley rats were ovariectomized rendered osteopenic. A drill hole injury was generated mid femoral bones all animals. Med treatment commenced day after continued for 15 days. PTH taken as a reference standard. Fifteen days post-treatment, animals sacrificed. Bones collected histomorphometry studies at site micro-computed...
Objective: Recent studies have shown that immune system plays a major role in pathophysiology of postmenopausal osteoporosis. Previously we phytoestrogens like daidzein and medicarpin exhibit immunoprotective effects, by virtue which they alleviate bone loss. With this background, methoxyisoflavones formononetin (formo) isoformononetin (isoformo) been studied for preventing loss ovariectomized rats were tested their immunomodulatory effects estrogen-deficient mice model. Methods: Adult...
A large number of current studies indicate that inflammatory mediators may contribute to depression in experimental models as well human beings. Nevertheless, the subject, whether anti-inflammatory treatments can prevent still remains controversial. In present study, a chronic mild stress (CMS) model male Sprague Dawley rats was used investigate role drugs treatment depression. All animals different groups, except normal control group, were exposed CMS procedure for 28 days and concurrently...
High grade serous ovarian cancer (HGSC) is the most common and deadly type of cancer, largely due to difficulties in early diagnosis rapid metastasis throughout peritoneal cavity. Previous studies have shown that expression Notch3 correlates with worse prognosis increased tumorigenic cell behaviors HGSC. We investigated mechanistic role a model metastatic using murine surface epithelial line, ID8 IP2. was activated IP2 cells via intracellular domain (Notch3IC). Notch3IC injected...
Clinically healthy non-descript adult goats (18) of either sex, were divided equally in 2 groups (group A and B) to study the application ex-vivo expanded autologous bone marrow derived mesenchymal stem cells for repair transected tendon caprine. The aspirate was collected from iliac crest cultured. When reached 70–80% confluency, they harvested using 0.25% trypsin-EDTA. In both groups, superficial digital flexor (SDFT) transected. group B (test group), (BM-MSCs) implanted at site injury...