A5059629283- Electrochemical Analysis and Applications
- Photosynthetic Processes and Mechanisms
- Electrochemical sensors and biosensors
- Photoreceptor and optogenetics research
- Analytical Chemistry and Sensors
- TGF-β signaling in diseases
- Molecular Junctions and Nanostructures
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Microbial Fuel Cells and Bioremediation
- Microfluidic and Capillary Electrophoresis Applications
- Conducting polymers and applications
- 3D Printing in Biomedical Research
- Spectroscopy and Quantum Chemical Studies
- Neuroscience and Neural Engineering
- thermodynamics and calorimetric analyses
- Force Microscopy Techniques and Applications
- Preterm Birth and Chorioamnionitis
- Microfluidic and Bio-sensing Technologies
- Bacteriophages and microbial interactions
- Electrocatalysts for Energy Conversion
- Fuel Cells and Related Materials
- Neonatal Respiratory Health Research
- Advanced Nanomaterials in Catalysis
Vanderbilt University
2016-2025
Multidisciplinary Association for Psychedelic Studies
2023
University of Pittsburgh
2016
Nashville Oncology Associates
2004-2015
Division of Chemistry
2010
Center for Nanoscale Science and Technology
2010
United States Military Academy
2008
University of Minnesota
2001
University of North Carolina at Chapel Hill
1999-2000
The University of Texas at Austin
1995-1998
Multistep deposition and reactive decomposition of a precursor molecule containing one Pt Ru atom on herringbone graphitic carbon nanofibers (GCNFs) affords Pt−Ru/GCNF nanocomposite Pt−Ru alloy nanoclusters widely dispersed the GCNF support. The has total metal content 42 wt % with bulk Pt/Ru atomic ratio ca. 1:1, having average particle sizes 6 nm as calculated from XRD peak widths or 7 measured directly TEM images. electrochemical analysis as-prepared stored under ambient conditions...
Place-exchange and amide-forming coupling reactions represent two facile efficient routes to poly-functionalization of water-soluble nanoparticles. In this paper, place-exchange with tiopronin-MPCs are described their products characterized by 1H 31P NMR, capillary electrophoresis, electrochemistry, fluorescence spectroscopy. ligands yield about half the ligand exchange expected on basis solution stoichiometry a nonselective were not noticeably affected steric encumbrances. Tiopronin-MPCs...
Electronic conductivity, σEL, in solid-state films of alkanethiolate monolayer protected Au clusters (Au MPCs) occurs by a bimolecular, electron self-exchange reaction, whose rate constant is controlled (a) the core-to-core tunneling electronic charge along chains and (b) mixed valency MPC cores (e.g., mixture with different charges). The mechanism demonstrated an exponential relation between conductivity Au309(Cn)92 MPCs (average composition) n, chainlength, which varies from 4 to 16....
Plants and some types of bacteria demonstrate an elegant means to capitalize on the superabundance solar energy that reaches our planet with their conversion process called photosynthesis. Seeking harness Nature's optimization this process, we have devised a biomimetic photonic system makes use photoactive protein complex Photosystem I, immobilized surface nanoporous gold leaf (NPGL) electrodes, drive photoinduced electric current through electrochemical cell. The intent study is further...
The sophistication and success of recently reported microfabricated organs-on-chips human organ constructs have made it possible to design scaled interconnected systems that may significantly augment the current drug development pipeline lead advances in biology. Physiologically realistic live microHuman (μHu) milliHuman (mHu) operating for weeks months present exciting important engineering challenges such as determining appropriate size each ensure relative functional activity, achieving...
Intensely and broadly absorbing nanoparticles (IBANs) of silver protected by arylthiolates were recently synthesized showed unique optical properties, yet question their dispersity molecular formulas remained. Here IBANs are identified as a superatom complex with formula Ag(44)(SR)(30)(4-) an electron count 18. This character is shared 4-fluorothiophenol or 2-naphthalenethiol. The purity determined mass spectrometry confirmed sedimentation velocity-analytical ultracentrifugation. data also...
Abstract The long‐term success of photosynthetic organisms has resulted in their global superabundance, which is sustained by widespread, continual mass‐production the integral proteins that photocatalyze chemical processes natural photosynthesis. Here, a fast, general method to assemble multilayer films composed one such photocatalytic protein complex, Photosystem I (PSI), onto variety substrates reported. resulting films, akin stacked thylakoid structures leaves, consist matrix permeable...
Tuning the Fermi energy of silicon through doping leads to alignment bands with redox active sites photosystem I. Integrating I films p-doped results in highest reported photocurrent enhancement for a biohybrid electrode based on Detailed facts importance specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please note: The publisher is responsible content functionality any...
Novel biophotovoltaic devices were prepared by electrochemically entrapping Photosystem I in a conductive polyaniline film, grown<italic>in situ</italic>on TiO<sub>2</sub>anodes.
This paper describes gold, silver, and palladium nanoparticles coated with monolayers of trimethyl(mercaptoundecyl)ammonium ligands. The monolayer-protected clusters (MPCs) are synthesized in aqueous medium water soluble. In dry films, their highly charged surfaces inhibit the interdigitation monolayer chains known (transmission electron microscopy) films alkanethiolate-coated nanoparticles. UV−vis spectra exhibit surface plasmon bands for Au Ag MPCs at expected wavelengths but none Pd...
Several new platinum monolayer protected clusters (MPCs) have been synthesized and characterized. Two methods of reduction were used depending on the solubility thiol: sodium borohydride for water-soluble thiols lithium triethylborohydride organic soluble thiols. In general, reactant solutions containing a 1:1 thiol/Pt ratio yielded best particles in single-phase reaction. Higher ratios produced lower yields MPCs, while much gray-black precipitates. The Pt MPCs as catalysts to hydrogenate...
Monolayer-protected gold nanoparticles have great potential as novel building blocks for the design of new drugs and therapeutics based on easy ability to multifunctionalize them biological targeting drug activity. In order create that are biocompatible in vivo, polyethylene glycol functional groups been added many previous multifunctionalized particles eliminate nonspecific binding. Recently, monolayer-protected with mercaptoglycine functionalities were shown elicit deleterious effects...
Photosystem I (PSI) has drawn widespread interest for use in biomimetically inspired energy conversion devices upon extracting it from plants or cyanobacteria and assembling at surfaces. Here, we demonstrate that a critically dense monolayer of spinach-derived PSI must be formed on an electrode surface to achieve optimal photocurrents, introduce new method preparing these monolayers reduces the time required assembly by approximately 80-fold comparison adsorption solution. This consists...
A simple screening method: Phase segregation and domain formation is observed within the protecting monolayer of gold nanoparticles (AuNPs) using ion mobility mass spectrometry (IM-MS), a two-dimensional gas-phase separation technique. Experimental data are compared to theoretical model. Deviations from this model provide evidence for nanophase resulting in anisotropic AuNPs.
We report the fabrication of a hybrid light-harvesting electrode consisting photosystem I (PSI) proteins extracted from spinach and adsorbed as monolayer onto electrically contacted, large-area graphene. The transparency graphene supports choice an opaque mediator at elevated concentrations. For example, we photocurrent 550 nA/cm(2) PSI on in presence 20 mM methylene blue, which yields blue solution. PSI-modified has total thickness less than 10 nm demonstrates photoactivity that is order...
A microphysiometer capable of measuring changes in extracellular glucose, lactate, oxygen, and acidification rate has been developed by incorporating modified electrodes into a standard Cytosensor Microphysiometer plunger. Glucose lactate are measured indirectly at platinum amperometric oxidation hydrogen peroxide, which is produced from catalysis glucose films containing their respective entrapped oxidase. Oxygen amperometrically electrode coated with Nafion film, while the...
We have developed glucose and lactate ultramicroelectrode (UME) biosensors based on oxidase (with enzymes immobilized onto Pt UMEs by either electropolymerization or casting) for scanning electrochemical microscopy (SECM) determined their sensitivity to lactate, respectively. The results of our evaluations reveal different advantages sensors constructed each method: improved shorter manufacturing time hand-casting, increased reproducibility electropolymerization. acquired amperometric...