A5052306709- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- HVDC Systems and Fault Protection
- Cytomegalovirus and herpesvirus research
- RNA modifications and cancer
- Parasitic Infections and Diagnostics
- HIV Research and Treatment
- Sex work and related issues
- interferon and immune responses
- Epigenetics and DNA Methylation
Université Grenoble Alpes
2020-2025
Inserm
2020-2025
Centre National de la Recherche Scientifique
2020-2025
Unit of Virus Host Cell Interactions
2020-2023
Institut de Biosciences et Biotechnologies
2020-2023
Institut pour l'avancée des biosciences
2020-2023
Institut Pasteur
2023
Abstract Sexual reproduction of Toxoplasma gondii , confined to the felid gut, remains largely uncharted owing ethical concerns regarding use cats as model organisms. Chromatin modifiers dictate developmental fate parasite during its multistage life cycle, but their targeting stage-specific cistromes is poorly described 1,2 . Here we found that transcription factors AP2XII-1 and AP2XI-2 operate tachyzoite stage, a hallmark acute toxoplasmosis, silence genes necessary for merozoites, stage...
Correct 3'end processing of mRNAs is one the regulatory cornerstones gene expression. In a parasite that must adapt to requirements its multi-host life style, there need adopt additional means partition distinct transcriptional signatures closely and tandemly arranged stage-specific genes. this study, we report our findings in T. gondii an m6A-dependent polyadenylation serving as barrier at these loci. We identify core complex within establish CPSF4 reader for m6A-modified mRNAs, via YTH...
Sexual reproduction of
Abstract Background Biomarker discovery remains a major challenge for predictive medicine, in particular, the context of chronic diseases. This is true widespread protozoan Toxoplasma gondii which establishes long-lasting parasitism metazoans, humans included. microbe successively unfolds distinct genetic programs that direct transition from high to low replicative potential inside host cells. As slow-replicating cell, T. bradyzoite developmental stage persists enclosed cyst compartment...
Abstract Correct 3’end processing of mRNAs is regarded as one the regulatory cornerstones gene expression. In a parasite that must answer to high requirements its multi-host life style, there great need adopt additional means partition distinct transcriptional signatures closely and tandemly-arranged stage specific genes. this study, we report on our findings in T. gondii an m6A-dependent polyadenylation serving barrier at these loci . We identify core complex within establish CPSF4 reader...