A5025713305- Bone health and osteoporosis research
- Hip and Femur Fractures
- Bipolar Disorder and Treatment
- Vitamin D Research Studies
- Pharmacological Effects and Toxicity Studies
- Balance, Gait, and Falls Prevention
- Hip disorders and treatments
- Personality Disorders and Psychopathology
- Nutrition and Health in Aging
- Cerebral Palsy and Movement Disorders
- Health disparities and outcomes
- Tryptophan and brain disorders
- Frailty in Older Adults
- Mental Health and Psychiatry
- Schizophrenia research and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Genetic Syndromes and Imprinting
- Mental Health Treatment and Access
- Nutritional Studies and Diet
- Stress Responses and Cortisol
- Bone and Joint Diseases
- Cardiac Health and Mental Health
- Chronic Disease Management Strategies
- Vitamin K Research Studies
- Electrolyte and hormonal disorders
Deakin University
2016-2025
Barwon Health
2010-2024
Milken Institute
2023
University of Michigan
2023
Brigham and Women's Hospital
2023
University of Oslo
2023
Oslo University Hospital
2023
University of Calgary
2020
Alberta Children's Hospital
2020
Geelong Hospital
2020
Improving vitamin D status may be an important modifiable risk factor to reduce falls and fractures; however, adherence daily supplementation is typically poor.To determine whether a single annual dose of 500,000 IU cholecalciferol administered orally older women in autumn or winter would improve the fracture.A double-blind, placebo-controlled trial 2256 community-dwelling women, aged 70 years older, considered at high fracture were recruited from June 2003 2005 randomly assigned receive...
Background Epidemiological evidence supports a relationship between vitamin D and mental well-being, although from large-scale placebo-controlled intervention trials is lacking. Aims To examine if supplementation has beneficial effect on mood in community-dwelling older women; single annual large dose of role the prevention depressive symptoms; there an association serum 25-hydroxyvitamin levels health. Method A double-blind, randomised, trial women aged 70 or (the Vital Study:...
Objectives . To compare 12-month falls recall with reported prospectively on daily calendars in a clinical trial of women aged ≥70 years. Methods 2,096 community-dwelling at high risk and/or fracture completed calendar and standardised interviews when were recorded, for 12 months. Data compared to question that categorised status as “no falls,” “a few times,” “several,” “regular” falls. Results 898 (43%) participants fall whom 692 (77%) recalled fall(s) Participants who did not older (median...
ABSTRACT Osteoporosis and osteopenia are increasingly prevalent conditions among older adults. Not only do the fractures associated with poor bone health have significant consequences for individual, but also their economic impact is placing increasing financial burden on governments society. This study aimed to determine direct cost of osteoporosis, osteopenia, Australians aged 50 years in 2017. uses previous Australian data incidence prevalence osteoporosis together recent service...
We investigated change in health-related quality of life due to fracture Australian adults aged over 50 years. Fractures reduce with the loss sustained at least 12 months. At a population level, was equivalent 65 days full health per fracture. aimed quantify (HRQoL) that occurred as consequence using EQ-5D-3 L questionnaire. Adults ≥50 years low moderate energy were recruited from eight study centres across Australia. This prospective included an 18-month follow-up participants within 2...
Persistent functional impairment is common in bipolar disorder (BD) and influenced by a number of demographic, clinical, cognitive features. The goal this project was to estimate compare the influence key factors on community function multiple cohorts well-characterized samples individuals with BD.Thirteen from 7 countries included n = 5882 BD across sites. statistical approach consisted systematic uniform application analyses Each site performed logistic regression analysis empirically...
Psychotropic agents known to cause sedation are associated with an increased risk of falls, but the role psychiatric illness as independent factor for falls is not clear. Thus, this study aimed investigate association between disorders, psychotropic medication use and risk. This examined data collected from 1062 women aged 20-93 yr (median 50 yr) participating in Geelong Osteoporosis Study, a large, ongoing, population-based study. Depressive anxiety disorders preceding 12-month period were...
Abstract Background The mind-body nexus has been a topic of growing interest. Further data are however required to understand the specific relationship between mood and anxiety disorders individual physical health conditions, verify whether these psychiatric linked overall medical burden. Methods This study examined collected from 942 men, 20 97 years old, participating in Geelong Osteoporosis Study. A lifetime history was identified using Structured Clinical Interview for DSM-IV-TR Research...
Objective: We aimed to describe the prevalence and age distribution of personality disorders their comorbidity with other psychiatric in an age-stratified sample Australian women aged ⩾25 years. Methods: Individual (paranoid, schizoid, schizotypal, histrionic, narcissistic, borderline, antisocial, avoidant, dependent, obsessive-compulsive), lifetime mood, anxiety, eating substance misuse were diagnosed utilising validated semi-structured clinical interviews (Structured Clinical Interview for...
Randomised, placebo-controlled trials are needed to provide evidence demonstrating safe, effective interventions that reduce falls and fractures in the elderly. The quality of a clinical trial is dependent on successful recruitment target participant group. This paper documents successes failures recruiting over 2,000 women aged at least 70 years higher risk or onto six duration. characteristics study participants baseline also described for this study. Vital D Study recruited older...
Objectives High levels of disability, functional impairment and mortality are independently associated with fracture depression, however the relationship between depression is uncertain. The aim this study was to investigate whether subsequent depressive symptoms in a population-based sample women. Design A age-matched versus non-fracture cohorts Setting Barwon Statistical Division, southeastern Australia. Participants Two samples women aged ≥35 years were drawn from Geelong Osteoporosis...
The extent of muscle deterioration associated with ageing or disease can be quantified by comparison appropriate reference data. objective this study is to present normative data for lower-limb strength and quality 573 males 923 females aged 20-97 yr participating in the Geelong Osteoporosis Study southeastern Australia.In cross-sectional study, measures hip flexors abductors were obtained using a Nicholas manual tester, hand-held dynamometer (HHD; kg). Leg lean mass was measured dual energy...
The important trace elements, copper and selenium, have diverse effects on human health. As well as other roles in living tissues, these elements are toxic at high levels but key constituents of various enzymes proteins essential for maintaining physiological However, links between dietary intakes particularly copper, bone mineral density (BMD) humans remain uncertain. This study aimed to investigate whether selenium associated with BMD women. Dietary were assessed 575 women the Geelong...