A5038448691- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Functional Brain Connectivity Studies
- Electrolyte and hormonal disorders
- Treatment of Major Depression
- Traumatic Brain Injury Research
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Adolescent and Pediatric Healthcare
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- Neurological and metabolic disorders
- Transcranial Magnetic Stimulation Studies
- Psychosomatic Disorders and Their Treatments
- Mental Health and Psychiatry
- Memory and Neural Mechanisms
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Stroke Rehabilitation and Recovery
- Dementia and Cognitive Impairment Research
University of British Columbia
2015-2024
BC Mental Health & Substance Use Services
2013-2024
British Columbia Children's Hospital
2020-2023
Milken Institute
2023
University of Michigan–Ann Arbor
2023
Brigham and Women's Hospital
2023
University of Oslo
2023
Oslo University Hospital
2023
Okanagan University College
2022
Centre for Movement Disorders
2011-2022
Article abstract—We examined the pattern of neuroanatomic abnormalities in adults with Down9s syndrome (DS) and cognitive correlates these abnormalities. Specifically, we compared this what would be predicted by hypotheses attributing DS pathology to either premature aging or Alzheimer9s disease. We measured a number brain regions on MRIs 25 subjects: 13 persons phenotype 12 age- sex-matched healthy volunteers. Study participants had no history cardiovascular disease, diabetes, thyroid...
Although cognitive impairment is an important clinical feature of bipolar disorder, it unknown whether deficits are present at illness onset. The purpose this study was to determine neuropsychological impairments in clinically stable patients with disorder shortly after resolution their first manic episode.Within a large university medical center, 45 recently diagnosed (DSM-IV-TR) type I were evaluated episode, along 25 matched healthy comparison subjects. Participants administered battery...
Objective The aim was to examine the heterogeneity of psychosocial outcomes in euthymic bipolar disorder (BD) patients and analyse potential influence distinct variables on functioning. Method Using a hierarchical cluster exploratory analysis, 143 with diagnosis BD were grouped according their functional performance based domains scores Functioning Assessment Short Test (FAST). resulting groups compared sociodemographic, clinical neurocognitive find factors associated each cluster. Results...
Neuroimaging studies have provided robust evidence that schizophrenia is associated with structural brain abnormalities. However, the underlying pathophysiology of these changes still unknown. By evaluating morphology early in course illness, confounding effects treatment and duration illness are minimized. The goal this study was to evaluate structure patients who had received no or minimal neuroleptics.Magnetic resonance imaging used 12 male female experiencing their first episode (mean...
<b><i>Objective:</i></b> To investigate longitudinal cognitive functioning in patients with brain tumor treated modern highly conformal fractionated partial radiation therapy (RT). <b><i>Methods:</i></b> Seventeen (of 22 initial consecutive patients) adults primarily low-grade neoplasms who underwent either biopsy or resection were tested at pre-RT baseline and 3, 6, 12, 24 months after baseline. Participants classified as RT-treated nonprogressors (n = 12) progressors 3) based on serial...
Objective: To describe clinical characteristics, course, and outcome during a 1-year period after the first manic episode in patients with bipolar disorder (BD). Methods: This paper describes project design, demographics, outcomes, predictors at 6 months to 1 year of follow-up 53 recruited subjects first-episode mania from Systematic Treatment Optimization Program for Early Mania. Results: Survival analysis recurrence mood episodes showed that 46.7% survived without follow-up, mean...
Bipolar I disorder (BD-I) is associated with gray matter volume (GMV) alterations in neural regions important for emotional regulation. Reductions found patients multiple episodes are not seen at illness onset, suggesting that changes occur progression, although no prospective studies to date have examined this. In the present study, we assessed GMV baseline and one year following a first manic episode, examining impact of episode recurrence on trajectory change.A total 41 recently remitted...
<h3>Importance</h3> Major depressive episodes in bipolar disorder are common and debilitating. Repetitive transcranial magnetic stimulation is well established the treatment of major disorder, intermittent theta burst (iTBS) protocol replacing conventional protocols because noninferiority reduced delivery time. However, iTBS has not been adequately studied and, therefore, its efficacy uncertain. <h3>Objective</h3> To determine whether to left dorsolateral prefrontal cortex (LDLPFC) safe...
Persistent functional impairment is common in bipolar disorder (BD) and influenced by a number of demographic, clinical, cognitive features. The goal this project was to estimate compare the influence key factors on community function multiple cohorts well-characterized samples individuals with BD.Thirteen from 7 countries included n = 5882 BD across sites. statistical approach consisted systematic uniform application analyses Each site performed logistic regression analysis empirically...
Prognostication is very important to clinicians and families during the early management of severe traumatic brain injury (sTBI), however, there are no gold standard biomarkers determine prognosis in sTBI. As has been demonstrated several diseases, measurement serum metabolomic profiles can be used as sensitive specific predict outcomes.We prospectively enrolled 59 adults with sTBI (Glasgow coma scale, GCS ≤ 8) a multicenter Canadian TBI (CanTBI) study. Serum samples were drawn for profiling...
Background Although cognitive deficits in bipolar disorder have been associated with diminished functional outcome, this relationship has studied primarily through cross-sectional designs, and not patients early the course of illness. The purpose study was to evaluate impact functioning on longitudinal 6-month clinical outcome recently diagnosed clinically stable disorder. Method A total 53 DSM-IV type I were assessed within 3 months their first manic episode using a neuropsychological...
Traumatic brain injury (TBI) is a major public health concern worldwide, contributing to high rates of injury-related death and disability. Severe traumatic (sTBI), although it accounts for only 10% all TBI cases, results in mortality rate 30–40% significant burden disability those that survive. This study explored the potential metabolomics diagnosis sTBI examine probable primary secondary sTBI. Serum samples from 59 adult patients with 35 age- sex-matched orthopedic controls were subjected...
We investigated age-related differences in the cerebellar vermis. The areas of five vermal regions interest were estimated from digitized midsagittal magnetic resonance imaging scans 29 healthy volunteers and 30 neurologically intact patients (aged 18 to 78 years) who free vestibular symptoms, seizures, psychosis, or alcoholism. included following: (1) lingula centralis, (2) culmen, (3) declive, folium, tuber, (4) pyramis, (5) uvula nodulus. ventral pons was used as a control region. After...