A5011906368- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Schizophrenia research and treatment
- Electrolyte and hormonal disorders
- Tryptophan and brain disorders
- Eating Disorders and Behaviors
- Adolescent and Pediatric Healthcare
- Genetics and Neurodevelopmental Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Advanced NMR Techniques and Applications
University of British Columbia
2011-2021
Centre for Movement Disorders
2016
Bipolar I disorder (BD-I) is associated with gray matter volume (GMV) alterations in neural regions important for emotional regulation. Reductions found patients multiple episodes are not seen at illness onset, suggesting that changes occur progression, although no prospective studies to date have examined this. In the present study, we assessed GMV baseline and one year following a first manic episode, examining impact of episode recurrence on trajectory change.A total 41 recently remitted...
Article Abstract Objective: Cognitive impairments are present immediately following recovery from a first episode of mania, although at lesser severity than those seen in more chronic patients with bipolar I disorder. Little is known about how deficits evolve over the course illness, however, and whether these changes associated disease progression. Method: Patients disorder (DSM-IV-TR) receiving naturalistic clinical follow-up Systematic Treatment Optimization Program for Early Mania...
Objectives Executive function impairments are a core feature of bipolar I disorder ( BD ‐I), not only present during acute episodes but also persisting following remission mood symptoms. Despite advances in knowledge regarding the neural basis executive functions healthy subjects, research into morphological abnormalities underlying deficits ‐I is lacking. Methods Patients with within three months sustained from their first manic episode (n = 41) underwent neuropsychological testing and 3T...
In cross-sectional studies, elevated body mass index (BMI) is associated with cognitive impairment in bipolar disorder (BD). We investigated the direction of this association by prospectively examining changes BMI and cognition.We measured performance six domains over 12 months 80 adolescent young adult BD patients 46 healthy comparison subjects (HS). Ninety-three percent received pharmacotherapy 84% were euthymic. used repeated-measures ancova longitudinal mixed models to investigate...
Although associations between antipsychotic use and neuropsychological impairment in bipolar I disorder have been observed, there is a lack of studies comparing the effects specific agents used this population. We compared performance patients receiving maintenance treatment with mood stabilizer monotherapy (n=15), adjunctive risperidone (n=15) or quetiapine (n=17), group demographically matched healthy controls (n=28) on tests executive function (working memory, set shifting, inhibition)...
Article AbstractObjective: There is a bidirectional relationship between obesity and mood disorders, with each increasing the risk of developing other. This suggests that they have overlapping pathophysiologic mechanisms. Adipose tissue-derived hormones, or adipokines, regulate appetite metabolism activity in limbic brain regions, making them potential shared etiologic factors elevated body mass index (BMI) disorders. However, precise relationships BMI, mood, adipokines are unknown.Methods:...
Previous studies reported decreased N-acetyl aspartate and increased Glx (the sum of glutamate plus glutamine) in bipolar disorder. Since these included patients at different stages illness, it is unknown whether changes have a causal role or consequence multiple episodes treatments. The early-stage disorder the potential to provide answers issues. Therefore, we evaluated levels hippocampi first-episode health subjects baseline 12 months, examined impact episode recurrence on measures.We...
While clinical guidelines exist for the management of bipolar disorder (BD), there are significant challenges to their widespread dissemination and implementation in practice. The Canadian Network Mood Anxiety Treatment Improving Patient Care Outcomes Bipolar Disorder (C-IMPACT BD) web-based application was developed use at point-of-care improve adherence evidence-based pharmacological BD.C-IMPACT BD uses a practice assessment which, via adaptive questioning patient-specific information,...