A5057177024- Transcranial Magnetic Stimulation Studies
- Treatment of Major Depression
- Suicide and Self-Harm Studies
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Electroconvulsive Therapy Studies
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Child and Adolescent Psychosocial and Emotional Development
- Psychosomatic Disorders and Their Treatments
- Schizophrenia research and treatment
- Dementia and Cognitive Impairment Research
- Neurological disorders and treatments
- Stress Responses and Cortisol
- Mental Health Research Topics
- Maternal Mental Health During Pregnancy and Postpartum
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Cerebrospinal fluid and hydrocephalus
- Obsessive-Compulsive Spectrum Disorders
- Mental Health Treatment and Access
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pain Management and Treatment
- Advanced MRI Techniques and Applications
- Homicide, Infanticide, and Child Abuse
University of Calgary
2018-2025
Centre for Addiction and Mental Health
2021-2025
Centre for Mental Health
2025
University of Tübingen
2024
Hertie Institute for Clinical Brain Research
2024
Harvard University
2024
McLean Hospital
2024
Ontario Brain Institute
2020-2022
University of British Columbia
2012-2017
McGill University
2006-2016
It is unclear whether the association between impulsive-aggressive behaviours and suicide exists across different ages.Via psychological autopsy, we examined a total of 645 subjects aged 11-87 years who died by suicide. Proxy-based interviews were conducted using SCID-I & SCID-II or K-SADS series behavioural personality-trait assessments. Secondarily, 246 living controls similarly assessed.Higher levels impulsivity, lifetime history aggression, novelty seeking associated with younger age...
Background: Mild behavioral impairment (MBI) and subjective cognitive decline (SCD) are dementia risk states, potentially represent neurobehavioral neurocognitive manifestations, respectively, of early stage neurodegeneration. Both MBI SCD predict incident dementia, associated with known biomarkers, both represented in the NIA-AA research framework for AD Stage 2 (preclinical disease). Objective: To assess associations SCD, alone combination, functional a population older adults. We tested...
Mild cognitive impairment (MCI) is an at-risk state for dementia; however, not all individuals with MCI transition to dementia, and some revert normal cognition (NC). Here, we investigate whether mild behavioral (MBI), the late-life onset of persistent neuropsychiatric symptoms (NPS), improves prognostic specificity MCI.
Background The Canadian Network for Mood and Anxiety Treatments (CANMAT) last published clinical guidelines the management of major depressive disorder (MDD) in 2016. Owing to advances field, an update was needed incorporate new evidence provide revised recommendations assessment MDD adults. Methods CANMAT convened a editorial group comprised academic clinicians patient partners. A systematic literature review conducted, focusing on reviews meta-analyses since 2016 guidelines....
Abstract Background Depressive disorders are the most common diagnosis among individuals who die by suicide, and intermittent theta-burst stimulation (iTBS) is a noninvasive treatment for those with difficult-to-treat depression at higher risk suicide. Previous data suggests that pairing iTBS D-cycloserine, partial N-methyl-D-aspartate (NMDA) receptor agonist, improves antidepressant outcomes. However, its impact on suicide not known. Methods We examine suicidal ideation implicit after...
There is substantial evidence suggesting that suicide aggregates in families. However, the extent of overlap between liability to and psychiatric disorders, particularly major depressive disorder, remains an important issue. Similarly, factors account for familial transmission suicidal behavior remain unclear. Thus, through direct blind assessment first-degree relatives, authors conducted a family study by examining three proband groups: probands who committed context living depressed with...
Article Abstract Background: Borderline personality disorder is a major risk factor for suicidal behavior, yet prediction of suicide completion remains unclear. It has been proposed that impulsivity and aggression interact to increase risk. Death by in borderline disorder, then, may be the result impulsivity, core feature interacting with violent-aggressive tendencies. Using case-control design, this study investigated clinical behavioral factors disorder. Method: One hundred twenty subjects...
<h3>Background:</h3> Suicidal behaviour aggregates in families, and the hypothalamic–pituitary–adrenal (HPA) axis noradrenergic dysregulation may play a role suicide risk. It is unclear whether stress heritable trait of or how it might increase We investigated reactivity autonomic nervous system HPA predisposition characterized effect this on neuropsychologic function. <h3>Methods:</h3> In family-based study first-degree relatives (<i>n</i> = 14) completers matched controls with no family...
Wide-field-of-view mesoscopic cortical imaging with genetically encoded sensors enables decoding of regional activity and connectivity in anesthetized behaving mice; however, the kinetics most can be suboptimal for vivo characterization frequency bands higher than 1-3 Hz. Furthermore, existing sensors, particular those that measure calcium (genetically indicators; GECIs), largely monitor suprathreshold activity. Using a sensor extracellular glutamate imaging, we demonstrate rapid virally...
Background: Assessing neuropsychiatric symptoms (NPS) in older adults is important for determining dementia risk. Mild behavioral impairment (MBI) an at-risk state cognitive decline and dementia, characterized by emergent NPS later life. MBI has significantly higher incidence than late life psychiatric conditions. However, its utility as a proxy neurodegeneration not been demonstrated. Plasma neurofilament light (NfL) validated biomarker of axonal damage, shown to associate with hallmarks...
The antidepressant effects of transcranial magnetic stimulation protocols for major depressive disorder (MDD) are thought to depend on synaptic plasticity. theta-burst (TBS) protocol plasticity is known be N-methyl-D-aspartate (NMDA)-receptor dependent, yet it unknown whether enhancing NMDA-receptor signaling improves treatment outcomes in MDD.To test low doses the partial-agonist, D-cycloserine, would enhance intermittent TBS (iTBS) MDD.This was a single-site 4-week, double-blind,...
Dementia assessment includes cognitive and behavioral testing with informant verification. Conventional is resource-intensive, uneven access. Online unsupervised assessments could reduce barriers to risk assessment. The aim of this study was assess the relationship between informant-rated changes participant-completed neuropsychological test performance in older adults, both measured remotely via an online platform, Brain Health Registry (BHR).Observational cohort study.Community-dwelling...