A5037952515- Pituitary Gland Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Growth Hormone and Insulin-like Growth Factors
- Trauma and Emergency Care Studies
- Retinal Development and Disorders
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury Research
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Epilepsy research and treatment
- Cardiac Arrest and Resuscitation
- Adrenal Hormones and Disorders
- Injury Epidemiology and Prevention
- Surgical Simulation and Training
- Ophthalmology and Eye Disorders
- Anatomy and Medical Technology
- Trauma Management and Diagnosis
- Adrenal and Paraganglionic Tumors
- Heat shock proteins research
- Meningioma and schwannoma management
- Cardiac, Anesthesia and Surgical Outcomes
- Axon Guidance and Neuronal Signaling
- Venous Thromboembolism Diagnosis and Management
- Functional Brain Connectivity Studies
- Cerebrospinal fluid and hydrocephalus
University of Alberta
2025
Dalhousie University
2015-2024
Nova Scotia Health Authority
2012-2024
Health Sciences Centre
2015-2024
Queen Elizabeth II Health Sciences Centre
2005-2023
University of Tennessee at Knoxville
2004-2016
Beijing Jiaotong University
2016
Tennessee Department of Transportation
2016
Moffitt Cancer Center
2015
University of South Florida
2015
Understanding a visual scene is an unsolved and daunting task, since scenes can contain large number of objects, their properties, interrelations. Extracting the full structure therefore infeasible, but often unnecessary, ...In modeling vision, there has been remarkable progress in recognizing range components, problem analyzing scenes, ultimate goal perception, still largely open. To deal with complete recent work focused ...
To investigate the influences of growth factors on axonal regeneration in mammalian CNS, we used intracellular tracers to quantitate effects brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-4/5, or NT-3 individual retinal ganglion cell (RGC) axons retinas adult rats after optic nerve transection. A single injection BDNF prolonged administration NT-4/5 by mini-pump increased axon branch median lengths eightfold but had no effect number branches formed RGC axons. did not...
Sellar masses (SM) are mostly benign growths of pituitary or nonpituitary origin that increasingly encountered in clinical practice. To date, no comprehensive population-based study has reported the epidemiology SM from North America.To determine province Nova Scotia, Canada.Data all pituitary-related referrals within were prospectively collected interlinked computerized registries starting November 2005. We conducted a retrospective analysis on patients with seen between 2005 and December...
Prognostication is very important to clinicians and families during the early management of severe traumatic brain injury (sTBI), however, there are no gold standard biomarkers determine prognosis in sTBI. As has been demonstrated several diseases, measurement serum metabolomic profiles can be used as sensitive specific predict outcomes.We prospectively enrolled 59 adults with sTBI (Glasgow coma scale, GCS ≤ 8) a multicenter Canadian TBI (CanTBI) study. Serum samples were drawn for profiling...
Traumatic brain injury (TBI) is a major public health concern worldwide, contributing to high rates of injury-related death and disability. Severe traumatic (sTBI), although it accounts for only 10% all TBI cases, results in mortality rate 30–40% significant burden disability those that survive. This study explored the potential metabolomics diagnosis sTBI examine probable primary secondary sTBI. Serum samples from 59 adult patients with 35 age- sex-matched orthopedic controls were subjected...
NEUROSURGERY PUBLICATIONS OPERATIVE PRACTICE CNS.ORG
Spontaneous spinal epidural hematomas are well-recognized but rare entities. The standard treatment for these has been prompt surgical evacuation. authors report a case of 76-year-old man who precipitously became paraplegic secondary to spontaneous hematoma and then experienced the complete resolution his neurological deficit hematoma. We conclude that conservative (nonoperative) management may be appropriate in those instances which there is early sustained recovery confirmed by radiological lesion.
This prospective, case control study evaluates quality of life (QOL), depressive affect, and memory outcomes epilepsy patients implanted with a vagus nerve stimulator (VNS).Three groups underwent assessment on two occasions: 1) VNS were tested before 12 months after implantation (n = 16); 2) who cerebral resective surgery pre- post-operatively 10); 3) under medical management 9). Group means compared the QOLIE-89, Geriatric Depression Scale, Wechsler Memory Scale - III, Observation...
Pituitary incidentalomas (PI) are frequently found on brain imaging. Despite their high prevalence, little is known about long-term natural history and there limited guidelines how to monitor them.We conducted a retrospective study compare epidemiological characteristics at presentation the of PI in population-based vs referral-based registries from two tertiary-care referral centers Canada.A total 328 patients with were included, whom 73% had pituitary adenomas (PA) 27% non-pituitary sellar...
Cortical spreading depolarization (CSD) is a promising target for neuroprotective therapy in traumatic brain injury (TBI). We explored the effect of NMDA receptor antagonism on electrically triggered CSDs healthy and brain-injured animals. Rats received either one moderate or four daily repetitive mild closed head impacts (rmTBI). Ninety-three animals underwent craniectomy with electrocorticographic (ECoG) local blood flow monitoring. In animals, ketamine memantine inhibited 44 to 88% 50 67%...
Backgound: “Blister-like” aneurysms of the supraclinoid internal carotid artery have recently been recognized as having unique pathological and clinical features. Little is known regarding their optimal treatment modality. Methods: We report a case “blister-like” aneurysm treated with Guglielmi detachable coil (GDC) embolization. Case Report: A 55-year-old man presented Hunt & Hess grade II subarachnoid hemorrhage. Computed tomography revealed diffuse blood. Cerebral angiography...
Purpose: The use of morning basal serum cortisol levels as an alternative to dynamic testing for assessment hypothalamic-pituitary-adrenal (HPA) axis has previously been reported. purpose this study was determine the lower and upper cutoff values that would obviate subsequent HPA testing. Methods: A single-centre, retrospective from a tertiary care endocrinology clinic conducted, analyzing data 106 adult individuals referred who had undergone 0800-0900 test followed by standard dose (250 μg)...
Objective: Acromegaly is frequently associated with altered facial appearance at the time of diagnosis. Furthermore, acromegaly also adverse psychological outcomes. We conducted a single-centre, cross-sectional study comparing patients growth hormone vs non-functioning pituitary adenomas (NFA) to assess association between morphometric changes and outcomes illness perception acromegaly. Methods: A seven-step scale was developed grade based on photographs. In addition, all were asked draw an...
Despite the identification of a small population cells residing in ciliary body (CB) adult mammalian eye that have capacity to generate retina-like vitro, their activity vivo remains quiescent. The authors sought identify whether predictable and time-dependent death retinal ganglion (RGCs) results activation progenitor-like within CB.RGC injury was induced by optic nerve axotomy mice. Thymidine-analogue lineage tracing immunocytochemistry were used dividing phenotype newly generated...