A5067451310- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Stress Responses and Cortisol
- Hormonal Regulation and Hypertension
- Childhood Cancer Survivors' Quality of Life
- Growth Hormone and Insulin-like Growth Factors
- Ophthalmology and Eye Disorders
- Impact of Technology on Adolescents
- Pain Management and Placebo Effect
- Health, psychology, and well-being
- Musculoskeletal pain and rehabilitation
- Pain Management and Treatment
- Empathy and Medical Education
- Myasthenia Gravis and Thymoma
- Mental Health Research Topics
- Attachment and Relationship Dynamics
- Glioma Diagnosis and Treatment
- Hormonal and reproductive studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Chronic Disease Management Strategies
- Patient-Provider Communication in Healthcare
- Hypothalamic control of reproductive hormones
- Diabetes Management and Education
- Spatial Neglect and Hemispheric Dysfunction
- Chronic Obstructive Pulmonary Disease (COPD) Research
Erasmus MC
2020-2023
Erasmus University Rotterdam
2022-2023
University of California, Merced
2013-2020
Leiden University Medical Center
2010-2017
Amsterdam UMC Location University of Amsterdam
2015
University of Amsterdam
2015
Abstract Context and Objective: Active Cushing’s disease is associated with cognitive impairments. We hypothesized that previous hypercortisolism in patients results irreversible impairments functioning. Therefore, our aim was to assess functioning after long-term cure of disease. Design: Cognitive assessment consisted 11 tests, which evaluated global functioning, memory, executive Patients Control Subjects: included 74 cured controls matched for age, gender, education. Furthermore, we 54...
Psychopathology and maladaptive personality traits are often observed during the active phase of Cushing's disease (CD). We hypothesized that patients with long-term cure CD show persistent psychopathology traits.Four questionnaires on frequently occurring in somatic illnesses were used, including Apathy Scale, Irritability Hospital Anxiety Depression Mood Symptoms Questionnaire short-form. Personality was assessed using Dimensional Assessment Pathology short-form (DAPPs).We included 51...
Patients with long-term remission of Cushing's disease (CD) have persistent psychological and cognitive impairments. It is unknown whether, to what extent, these impairments are accompanied by structural abnormalities in the brain. We aim investigate changes brain patients predominantly CD examine whether associated dysfunction clinical severity.A cross-sectional, case-control study.In 25 matched healthy controls, grey matter volumes regions interest (hippocampus, amygdala, anterior...
Illness perceptions pertain to the pattern of beliefs patients develop about their illness. are determinants quality life (QoL). Factors contributing persisting impaired QoL after Cushing's syndrome (CS) remain largely unknown. Therefore, objective this study was explore illness perceptions, as potentially modifiable psychological factors, in relation with long-term remission CS.Cross-sectional study.We included CS (n=52). were evaluated using Perception Questionnaire (IPQ)-Revised, and...
Background: A key goal of chronic obstructive pulmonary disease (COPD) care is to improve patients' quality life (QoL). For outcomes such as QoL, illness perceptions and coping are important determinants. Aim: The primary aim was assess the associations between perceptions, QoL in COPD patients. secondary compare patients with reference values derived from literature. Patients methods: total 100 were included study. asked complete Brief Illness Perception Questionnaire (B-IPQ), Utrecht...
Illness perceptions pertain to the beliefs patients develop about their illness, and these views are determinants of behavior directed at illness. quality life (QoL). QoL remains impaired in with biochemical control acromegaly, but illness were never studied patients. The aim current study was explore association long-term acromegaly. This a cross-sectional study. We included acromegaly (n = 81), compared them Dutch reference populations: acute pain (n=35) or chronic 63), Cushing's syndrome...
Coping strategies may affect quality of life, which is decreased in patients after treatment for Cushing's disease, acromegaly, or nonfunctioning pituitary macroadenomas (NFMA). We aimed to explore coping these because this has never been done before.We conducted a cross-sectional study.We included treated disease (n = 42), acromegaly 80), and NFMA 61). These were compared with three reference populations: an a-select sample from the Dutch population 712), chronic pain 59), receiving primary...
Active acromegaly is associated with psychopathology, personality changes, and cognitive dysfunction. It unknown whether, to what extent, these effects are present after long-term cure of acromegaly.The aim the study was assess traits, function in patients acromegaly.This a cross-sectional study.We studied 68 (13±1 yr) matched controls. We compared data 60 treated for nonfunctioning pituitary macroadenomas (NFMAs) Psychopathology assessed using Apathy Scale, Irritability Hospital Anxiety...
Hypopituitarism after traumatic brain injury (TBI) is considered to be a prevalent condition. However, prevalence rates differ considerably among reported studies, due differences in definitions, endocrine assessments of hypopituitarism, and confounding factors, such as timing evaluation the severity trauma. Aim To evaluate hypopituitarism large cohort TBI patients long-term follow-up using standardized evaluation. Study design Cross-sectional study.We included 112 with TBI, hospitalized for...
The multidimensional graded response model, an item theory (IRT) can be used to improve the assessment of surveys, even when sample sizes are restricted. Typically, health-based survey development utilizes classical statistical techniques (e.g. reliability and factor analysis). In a review four prominent journals within field Health Psychology, we found that IRT-based models were in less than 10% studies examining scale or assessment. However, implementing methods provide more details about...
Context: When working with health-related questionnaires, outlier detection is important. However, traditional methods of (e.g., boxplots) can miss participants "atypical" responses to the questions that otherwise have similar total (subscale) scores. In addition detecting outliers, it be clinical importance determine reason for status or response. Objective: The aim current study was illustrate how derive person fit statistics through a statistical method examining health-based...
Little is known about how women with isolated GnRH deficiency cope their condition. This study aimed to examine the health and informational needs of congenital hypogonadotropic hypogonadism (CHH) evaluate if experiences differ from more common forms infertility.Cross-sectional, multiple methods using web-based data collection reach dispersed rare disease patients.A community-based participatory research framework was employed develop an online survey collect quantitative qualitative data....
Context Patients with pituitary disease report impairments in Quality of Life (QoL) despite optimal biomedical care. Until now, the effects a self-management intervention (SMI) addressing psychological and social issues for these patients their partners have not been studied. Objective To examine SMI i.e. Patient Partner Education Programme Pituitary (PPEP-Pituitary). Design subjects A multicentre randomized controlled trial included 174 disease, 63 were allocated to either PPEP-Pituitary or...
Men with congenital hypogonadotrophic hypogonadism (CHH) typically require lifelong hormonal therapy, and discontinuing treatment can have negative health consequences. Little is known about adherence to or the psychosocial impact of CHH.A sequential, multiple methods approach was used. A quantitative online survey assessed treatment, depressive symptoms illness perceptions. Subsequently, qualitative focus groups explored patient-reported factors for adherence.Adult men CHH on at least 1...
Patients with adrenal insufficiency (AI) require daily and life-long hydrocortisone substitution risks of under- overreplacement, the necessity to adjust dose in stressful situations, a lack clinical biochemical parameters assess optimal dosing. The spectrum medication beliefs patients AI is currently unknown.The objective study was examine possible association between illness perceptions about (HC) AI.This cross-sectional evaluation 107 primary (n = 49), secondary after treatment Cushing's...
Patients report persisting impairment in quality of life (QoL) after treatment for pituitary disease. At present, there is no questionnaire to assess (a) whether patients with disease are bothered by these consequences, and (b) their needs support. To develop validate a disease-specific which incorporates patient perceived bother related the consequences disease, Items Leiden Bother Needs Questionnaire (LBNQ-Pituitary) were formulated based on results recent focus group study (n = 49 items)....