A5046673310- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Pancreatic function and diabetes
- Pituitary Gland Disorders and Treatments
- Diabetes Management and Education
- Nutritional Studies and Diet
- Adrenal and Paraganglionic Tumors
- Adenosine and Purinergic Signaling
- Obesity, Physical Activity, Diet
- Thyroid Cancer Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Adrenal Hormones and Disorders
- Epigenetics and DNA Methylation
- Renal and related cancers
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Cardiovascular Health and Risk Factors
- Neurological and metabolic disorders
- Genetic Syndromes and Imprinting
- Thyroid and Parathyroid Surgery
- Signaling Pathways in Disease
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Diabetic Foot Ulcer Assessment and Management
- Kruppel-like factors research
- Circular RNAs in diseases
Dalhousie University
2011-2024
Nova Scotia Health Authority
2020-2022
Queen Elizabeth II Health Sciences Centre
2020
Li Ka Shing Foundation
2016
St Michael’s Hospital
2016
St. Michael's Hospital
2013-2015
Although diabetes is the most common cause of end-stage renal disease (ESRD) worldwide, people with diabetic nephropathy will never develop ESRD but instead die cardiovascular (CV) (CVD). The first evidence kidney injury in often microalbuminuria, itself also an independent risk marker for CVD. two processes are closely associated, recent failure antialbuminuric therapies to affect CV outcomes has encouraged a reconsideration how albuminuria may occur and increased urinary albumin excretion...
Histone protein modifications control fate determination during normal development and dedifferentiation disease. Here, we set out to determine the extent which dynamic changes histones affect differentiated phenotype of ordinarily quiescent adult glomerular podocytes. To do this, examined consequences shifting balance repressive histone H3 lysine 27 trimethylation (H3K27me3) mark in Adriamycin nephrotoxicity subtotal nephrectomy (SNx) studies indicated that deletion methylating enzyme EZH2...
Epigenetic regulation of oxidative stress is emerging as a critical mediator diabetic nephropathy. In diabetes, damage occurs when there an imbalance between reactive oxygen species generation and enzymatic antioxidant repair. Here, we investigated the function histone methyltransferase enzyme enhancer zeste homolog 2 (EZH2) in attenuating injury podocytes, focusing on its endogenous inhibitor thioredoxin interacting protein (TxnIP). Pharmacologic or genetic depletion EZH2 augmented TxnIP...
To contend with the deleterious effects of accumulating misfolded protein aggregates or damaged organelles cells rely on a system quality control processes, among them autophagy-lysosome pathway. This pathway is itself controlled by master regulator transcription factor termed EB (TFEB). When TFEB localizes to cell nucleus it promotes expression number genes involved in clearance. Here, we set out determine 1) whether altered chronic kidney disease (CKD); 2) inhibition cytosolic deacetylase...
The posttranslational histone modifications that epigenetically affect gene transcription extend beyond conventionally studied methylation and acetylation patterns. By examining the means by which podocytes influence glomerular endothelial phenotype, we identified a role for phosphorylation of H3 on serine residue 10 (phospho-histone H3Ser10) in mediating activation diabetes. Culture media conditioned exposed to high glucose caused vascular cell adhesion protein 1 (VCAM-1) upregulation was...
Objective: Acromegaly is frequently associated with altered facial appearance at the time of diagnosis. Furthermore, acromegaly also adverse psychological outcomes. We conducted a single-centre, cross-sectional study comparing patients growth hormone vs non-functioning pituitary adenomas (NFA) to assess association between morphometric changes and outcomes illness perception acromegaly. Methods: A seven-step scale was developed grade based on photographs. In addition, all were asked draw an...
Binding of the receptor CXCR4 to its ligand stromal cell-derived factor 1 (SDF-1) promotes cell survival and is under influence a number regulatory processes including enzymatic inactivation by endopeptidases such as matrix metalloproteinase 9 (MMP-9). In light pivotal role that SDF-1/CXCR4 axis plays in renal development pathological growth cells, we explored function this pathway diabetic rats biopsies from patients with nephropathy, hypothesizing pro-survival effects resident cells would...
Background and Purpose Activated fibroblasts deposit fibrotic matrix in chronic kidney disease (CKD) G‐protein coupled receptors (GPCRs) are the most druggable therapeutic targets. Here, we set out to establish a transcriptional profile that identifies activated GPCRs they express. Experimental Approach RNA sequencing single cell qRT‐PCR were performed on mouse kidneys after unilateral ureteral obstruction (UUO). Candidate expression was evaluated mice with UUO or diabetes injected...
Mandelate racemase (MR, EC 5.1.2.2) from Pseudomonas putida catalyzes the Mg2+-dependent 1,1-proton transfer that interconverts enantiomers of mandelate. Crystal structures MR reveal phenyl group all ground-state ligands is located within a hydrophobic cavity, remote site proton abstraction. forms numerous electrostatic and H-bonding interactions with α-OH carboxyl groups substrate, suggesting these polar may remain relatively fixed in position during catalysis while free to move between two...
Abstract Background Insulinoma is a rare functioning pancreatic endocrine tumor, typically presenting as sporadic solitary lesion causing hypoglycemia. While these tumors can lead to marked autonomic and neuroglycopenic symptoms, the diagnosis often delayed. Case presentation We present case of 60-year-old Caucasian man with 1-year history progressive episodic confusion an unexpected finding symptomatic hypoglycemia during lactose tolerance test. Further inquiry revealed 8-year more subtle...
Post-transplant diabetes mellitus (PTDM) is an important complication after kidney transplantation that results in reduced patient and allograft survival. Although there are established risk factors for PTDM, whether pretransplant C-peptide levels associate with PTDM unknown. Therefore, this study, we aimed to examine the association of PTDM.This was a cohort study nondiabetic adult patients who underwent transplant Nova Scotia, Canada, between January 1, 2016, March 31, 2021, fasting...
Abstract Background Differentiated thyroid cancer (DTC) requires long-term follow-up due to the risk of delayed recurrence. Follow-up surveillance involves serial neck ultrasound (US) and thyroglobulin (Tg); however, optimal frequency diagnostic performance US outside specialized centres in higher patients is not well defined. We sought evaluate Tg advanced stage DTC. Methods retrospectively reviewed our database for with III IV DTC from 2006 2018, total thyroidectomy, at least 2 years...
Introduction: Skipping meals is an increasingly common practice to lose weight among North American adults of all bodyweights. However, due a lack long-term studies, the effect skipping on cardiometabolic health outcomes such as diagnosis type 2 diabetes mellitus (T2DM) or incident coronary heart disease (CHD) remains unknown, although previous short-term studies and risk factors for T2DM CHD have suggested plausible biological pathways relationship exist in either direction, protective...