A5049604021- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- SARS-CoV-2 and COVID-19 Research
- Ubiquitin and proteasome pathways
- vaccines and immunoinformatics approaches
- Circular RNAs in diseases
- Diabetes Treatment and Management
- PI3K/AKT/mTOR signaling in cancer
- Lipid metabolism and disorders
- CAR-T cell therapy research
- Diabetes Management and Research
- Animal Virus Infections Studies
- RNA modifications and cancer
- Extracellular vesicles in disease
- Evolution and Genetic Dynamics
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- Lipoproteins and Cardiovascular Health
- Cancer Genomics and Diagnostics
- Natural Antidiabetic Agents Studies
- Enterobacteriaceae and Cronobacter Research
- Genomics and Chromatin Dynamics
- Escherichia coli research studies
- Bacillus and Francisella bacterial research
Armed Forces Medical College
2025
National Chemical Laboratory
2022-2023
Birla Institute of Technology and Science, Pilani
2018-2021
Jawaharlal Institute of Post Graduate Medical Education and Research
2013
Abstract Cancer is a complex disease with fatal outcome. Early detection of cancer, by monitoring appropriate molecular markers very important for its therapeutic management. In this regard, the short non-coding RNA molecules, microRNAs (miRNAs) have shown great promise due to their availability in circulating fluids facilitating non-invasive cancer. study, an silico comparative analysis was performed identify specific signature miRNAs dysregulated across multiple carcinomas and...
Abstract Motivation Traditional cancer therapy is focused on eradicating fast proliferating population of tumor cells. However, existing evidences suggest survival sub-population cells that can resist chemotherapy by entering a ‘persister’ state minimal growth. These eventually survive to produce resistant drugs. The identifying appropriate targets eliminate the drug-tolerant ‘persisters’ remains challenge. Hence, deeper understanding distinctive genetic signatures lead resistance utmost...
Resistance to chemotherapy is one of the major hurdles in current cancer therapy. With increasing occurrence drug resistance, a paradigm shift treatment strategy required. Recently "medication vacation" has emerged as unique, yet uncomplicated which withdrawal pressure for certain duration allowed tumor cells regain sensitivity drug. However, little known about molecular alterations associated with such an outcome.In this study, human osteosarcoma (OS) resistant extensively used cisplatin,...
Cardiovascular diseases also called heart which include a group of disorders the and blood vessels. (CVDs) are leading cause death globally. The study was aimed to explore effect statins in cardiovascular diseases- chronic stable angina, acute coronary syndrome post PTCA patients by monitoring lipid profile. conducted Cardiology department Queen’s NRI Hospital. This is prospective, non-interventional observational 100 population attending OPD & IPD Hospital were recruited into with their...
Recurrence after cisplatin therapy is one of the major hindrances in management cancer. This necessitates a deeper understanding molecular signatures marking acquisition resistance. We therefore modeled response osteosarcoma (OS) cells to first-line chemotherapeutic drug cisplatin. A small population nondividing survived acute shock (persisters; OS-P). These regained proliferative potential over time re-instating again (extended persisters; OS-EP).In this study, we present expression profile...
Modern response to pandemics, critical for effective public health measures, is shaped by the availability and integration of diverse epidemiological outbreak data. Tracking variants concern (VOC) integral understanding evolution SARS-CoV-2 in space time, both at local level global context. This potentially generates actionable information when integrated with
Diabetes is due to either the pancreas not producing enough insulin, or cells of body responding properly insulin produced. This study was carried out with an objective determine efficacy Metformin other oral hypoglycemic agents, educate patients about disease and use drugs in diabetes mellitus evaluate which class agents shows more effectiveness. The each group received medication for 8 weeks duration. A comparative, glimepiride metformin type-2 DM a meta-analysis randomized controlled...
Summary The modern response to pandemics, critical for effective public health measures, is shaped by the availability and integration of diverse epidemiological outbreak data. Genomic surveillance has come forefront during coronavirus disease 2019 (COVID-19) pandemic at both local global scales identify variants concern. Tracking concern (VOC) integral understanding evolution severe acute respiratory syndrome 2 (SARS-CoV-2) in space time. Combining phylogenetics with data like case...