A5071988231- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
- Schizophrenia research and treatment
- Cancer survivorship and care
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Cancer-related cognitive impairment studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Dementia and Cognitive Impairment Research
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
- Suicide and Self-Harm Studies
- Mindfulness and Compassion Interventions
- Parkinson's Disease Mechanisms and Treatments
- Electroconvulsive Therapy Studies
- Health and Well-being Studies
- Ophthalmology and Visual Health Research
- Cognitive Functions and Memory
- Digital Mental Health Interventions
Institut d'Investigació Biomédica de Bellvitge
2023-2025
Institut Català d'Oncologia
2021-2025
Centro de Investigación Biomédica en Red de Salud Mental
2014-2025
Bellvitge University Hospital
2025
Instituto de Salud Carlos III
2021-2025
Universitat Oberta de Catalunya
2024
Institut Català d'Ornitologia
2024
College of the Holy Cross
2024
Centro de Investigación Biomédica en Red
2013-2024
Universitat Abat Oliba CEU
2021-2023
Deep brain stimulation (DBS) is currently tested as an experimental therapy for patients with treatment-resistant depression (TRD). Here we report on the short- and long-term (1 yr) clinical outcomes tolerance of DBS in eight TRD patients. Electrodes were implanted bilaterally subgenual cingulate gyrus (SCG; Broadman areas 24-25), stimulated at 135 Hz (90-μs pulsewidth). Voltage active electrode contacts adjusted to maximize short-term responses. Clinical assessments included 17-item...
Background Although white-matter abnormalities have been reported in middle-aged patients with major depressive disorder (MDD), few data are available on treatment-resistant MDD and the influence of relevant variables related to clinical burden illness is far from being well established. Method The present study examined microstructure a sample 52 different stages (treatment-resistant/chronic MDD, n = 18; remitted-recurrent 15; first-episode 19) 17 healthy controls, using diffusion tensor...
<h3>Background:</h3> Smaller hippocampal volumes in major depressive disorder (MDD) have been linked with earlier onset, previous recurrences and treatment refractoriness. The aim of our study was to investigate metabolite abnormalities the hippocampus associated past illness burden. <h3>Methods:</h3> Glutamate/glutamine (Glx), <i>N</i>-acetylaspartate (NAA) choline (Cho), potential markers glial/neuronal integrity membrane turnover, respectively, were measured adults depression healthy...
Findings of brain structural changes in major depressive disorder are still inconsistent, partly because some crucial clinical variables have not been taken into account.To investigate the effect on grey matter volumes.Voxel-based morphometry was used to compare 66 patients with depression at different illness stages (22 each first-episode, remitted-recurrent and treatment resistant/chronic depression) 32 healthy controls. Brain volumes were correlated variables.Voxel-based showed a...
Abstract: Exposure to acute and chronic stress has a broad range of structural effects on the brain. The brain areas commonly targeted in response models include hippocampus, amygdala, prefrontal cortex. Studies patients suffering from so-called stress-related disorders -embracing post-traumatic stress, major depressive anxiety disorders- have fairly replicated animal -particularly neuroendocrine inflammatory models- by finding alterations different areas, even early neurodevelopment....
Background Action mechanisms of therapeutic alliance in stepped and digital interventions remain unclear. Aims (a) To compare the development between psychosocial treatment as usual (PTAU) a intervention designed to prevent distress cancer patients; (b) analyse level agreement patients’ therapists’ ratings; (c) explore variables associated with intervention. Method A multicentre randomised controlled trial 184 newly diagnosed breast women was conducted. Patients were assigned or PTAU....
Desvenlafaxine, a serotonin-norepinephrine reuptake inhibitor, has demonstrated efficacy in improving affective symptoms of Major Depressive Disorder (MDD); however, its effects on associated cognitive and functional difficulties remain underexplored. This study seeks to assess the antidepressant desvenlafaxine patients with SSRI-resistant MDD, impact both objective subjective performance, where improvements occur independently clinical recovery or not, influence psychosocial functioning. An...
Background: Childhood maltreatment increases the risk of suicide attempts in general population, possibly having similar effects among patients with major depressive disorder (MDD). The few studies that have addressed this association been restricted to specific populations (e.g. treatment-resistant depression, personality disorders) and rarely taken sex into account. Objective: To examine impact childhood on MDD above beyond other factors potential confounders, while considering...
Bipolar disorder (BD) is characterized by episodic mood dysregulation, although a significant portion of patients suffer persistent cognitive impairment during euthymia. Previous magnetic resonance imaging (MRI) research suggests BD may have accelerated brain aging, observed as lower grey matter volumes. How these neurostructural alterations are related to the profile unclear.
Virtual Reality (VR) is considered an effective way to boost empathy by adopting the perspective of others, thus having clear potential for improving anti-bullying programs. However, this benefit VR limited both lack adequate content and empirical evidence its effectiveness. In article, we present process co-creation a set 360°-videos representing experience victims bullying from first-person perspective, involving secondary school students (N = 89). The impact presentation in terms...
Impairment of social cognition is documented in bipolar disorder (BD) and schizophrenia/schizoaffective (SCH). In healthy individuals, women perform better than men some its sub-domains. However, BD SCH the results are mixed. Our aim was to compare emotion recognition, affective Theory Mind (ToM) first- second-order cognitive ToM BD, subjects, investigate sex-related differences.120 patients (BD = 60, 60) 40 subjects were recruited. Emotion recognition assessed by Pictures Facial Affect...
Environmental factors such as psychosocial stress have demonstrated to an impact on the breast cancer (BC) course. This study aims explore of psychotherapy and stressful life events (SLE) BC survivors' illness trajectories. 68 women with underwent Positive Psychotherapy or Cognitive-Behavioral Stress Management 37 patients were included a control group. The effects distress reduction SLE their 5-year recurrence investigated. Additional analyses examined effect receiving vs. not type therapy...
Abstract Background Heterogeneity in cognitive functioning among major depressive disorder (MDD) patients could have been the reason for small-to-moderate differences reported so far when it is compared to other psychiatric conditions or healthy controls. Additionally, most of these studies did not take into account clinical and sociodemographic characteristics that played a relevant role variability. This study aims identify empirical clusters based on cognitive, variables sample acute MDD...
This study aimed to identify clinical and cognitive factors associated with increased risk for difficult-to-treat depression (DTD) or treatment-resistant (TRD).
Despite its high recurrence rate, major depression disorder (MDD) still lacks neurobiological markers to optimize treatment selection. The aim of this study was examine the prognostic potential clinical and structural magnetic resonance imaging (sMRI) in long-term MDD outcomes (COs).Forty-nine patients were grouped into one four different CO categories according their trajectory: recovery, partial remission, remission recurrence, chronic depression. Regression models including baseline...