A5069334922- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Autism Spectrum Disorder Research
- Eating Disorders and Behaviors
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Psychosomatic Disorders and Their Treatments
- Neural and Behavioral Psychology Studies
- Suicide and Self-Harm Studies
- Attention Deficit Hyperactivity Disorder
- Body Image and Dysmorphia Studies
- Treatment of Major Depression
- Perfectionism, Procrastination, Anxiety Studies
- Neurological disorders and treatments
- Neurotransmitter Receptor Influence on Behavior
- Cognitive Abilities and Testing
- Mental Health Treatment and Access
- Personality Disorders and Psychopathology
- Neural dynamics and brain function
- Digital Mental Health Interventions
- Homicide, Infanticide, and Child Abuse
- Mindfulness and Compassion Interventions
- COVID-19 and Mental Health
- Stuttering Research and Treatment
Hospital Clínic de Barcelona
2021-2024
Institute of Research and Innovation Parc Tauli
2020-2024
Centro de Investigación Biomédica en Red de Salud Mental
2013-2024
Instituto de Salud Carlos III
2012-2024
Universitat Autònoma de Barcelona
2009-2022
Corporació Sanitària Parc Taulí
2018-2020
Deleted Institution
2017
Institut d'Investigació Biomédica de Bellvitge
2012-2017
Bellvitge University Hospital
2012-2017
Universitat de Barcelona
2012-2017
Many people attending primary care (PC) have anxiety-depressive symptoms and work-related burnout compounded by a lack of resources to meet their needs. The COVID-19 pandemic has exacerbated this problem, digital tools been proposed as solution.
Cognitive behavioural therapy (CBT), including exposure and ritual prevention, is a first-line treatment for obsessive-compulsive disorder (OCD), but few reliable predictors of CBT outcome have been identified. Based on research in animal models, we hypothesized that individual differences basolateral amygdala-ventromedial prefrontal cortex (BLA-vmPFC) communication would predict patients with OCD.We investigated whether BLA-vmPFC resting-state functional connectivity (rs-fc) predicts OCD....
Abstract Common single-nucleotide polymorphisms (SNPs) account for a large proportion of the heritability obsessive-compulsive disorder (OCD). Co-ocurrence OCD and schizophrenia is commoner than expected based on their respective prevalences, complicating clinical management patients. This study addresses two main objectives: to identify particular genes associated with by SNP-based gene-based tests; test existence polygenic risk shared schizophrenia. The primary analysis was an exon-focused...
<h3>Background:</h3> Recent data from neuroimaging, genetic and clinical trials animal models suggest a role for altered glutamatergic neurotransmission in the pathogenesis of obsessive–compulsive disorder (OCD). The aim this study was to investigate whether variants <i>GRIN2B</i> gene, gene encoding NR2 subunit <i>N</i>-methyl-d-aspartate (NMDA) glutamate receptor, may contribute susceptibility OCD or different subphenotypes. <h3>Methods:</h3> Between 2003 2008, we performed case–control...
Background The size of particular sub-regions within the ventromedial prefrontal cortex (vmPFC) has been associated with fear extinction in humans. Exposure therapy is a form learning widely used treatment obsessive-compulsive disorder (OCD). Here we investigated relationship between morphometric measurements different vmPFC and exposure outcome OCD. Method A total 74 OCD patients 86 healthy controls underwent magnetic resonance imaging (MRI). Cortical thickness volumetric were obtained for...
Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition. Although structural brain alterations have been consistently reported in OCD, their interaction with particular clinical subtypes deserves further examination. Among other approaches, two-group classification patients autogenous and reactive obsessions has proposed. The purpose of the present study was to assess, by means voxel-based morphometry analysis, putative correlates this scheme OCD patients. Ninety-five 95...
While past twin studies indicate moderate levels of heritability "obsessive-compulsive related" and anxiety disorder symptoms, no single study has reported such estimates in the same population nor examined potential genetic sex differences. We assessed symptoms obsessive-compulsive disorder, body dysmorphic hoarding hypochondriasis, panic social phobia generalized 2,495 adult twins (1,468 female). Prevalence for corresponding symptom measures were determined using empirically derived...
The aetiological boundary between obsessive-compulsive related disorders (OCRDs) including disorder (OCD) and anxiety is unclear continues to generate debate.To determine the genetic overlap pattern of causal relationships among OCRDs disorders.Multivariate twin modelling methods a new regression analysis infer causation were used, involving 2495 male female twins.The amount common liability observed for OCD symptoms was higher when considering in model v. OCRD alone. emerged as risk factors...
Abstract Purpose: To study qualitatively different subgroups of social anxiety disorder (SAD) based on harm avoidance (HA) and novelty seeking (NS) dimensions. Method: One hundred forty-two university students with SAD (SCID-DSM-IV) were included in the study. The temperament dimensions HA NS from Cloninger's Temperament Character Inventory subjected to cluster analysis identify meaningful subgroups. identified compared for sociodemographics, severity, substance use, history suicide...
Though problematic hoarding is believed to be a universal human behavior, investigations of clinically-defined disorder (HD) have been confined almost exclusively Western countries. The current investigation sought describe and directly compare the features individuals meeting diagnostic criteria for HD across four distinct cultural settings. Participants were 82 DSM-5 HD, recruited assessed by trained clinicians at one project sites: London, Barcelona, Fukuoka, Rio de Janeiro. A series...
Background Negative mood states are composed of symptoms depression and anxiety, by a third factor related to stress, tension irritability. We sought clarify the nature relationships between factors studying twin pairs. Method A total 503 monozygotic pairs completed Depression Anxiety Stress Scales (DASS), an instrument that assesses depression, anxiety stress–tension. applied recently developed regression methodology – Inference about Causation from Examination FAmiliaL CONfounding (ICE...
Abstract Background Preliminary evidence suggests that hoarding disorder (HD) and obsessive-compulsive (OCD) may show distinct patterns of brain activation during executive performance, although results have been inconclusive regarding the specific neural correlates their differential dysfunction. In current study, we aim to evaluate differences in between patients with HD, OCD healthy controls (HCs) response inhibition, switching error processing. Methods We assessed 17 18 19 HCs. Executive...
Despite emotion regulation being altered in patients with obsessive-compulsive disorder (OCD), no studies have investigated its relation to multimodal amygdala connectivity. We compared corticolimbic functional and structural connectivity between OCD healthy controls (HCs), correlated this the dispositional use of strategies severity. (n = 73) HCs 42) were assessed for suppression reappraisal using Emotion Regulation Questionnaire (ERQ) severity Yale-Brown Obsessive-Compulsive Scale....