A5033208927- Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- Mesenchymal stem cell research
- Urologic and reproductive health conditions
- Soft tissue tumor case studies
- Cancer and Skin Lesions
- Cancer Cells and Metastasis
- Infectious Diseases and Tuberculosis
- Hair Growth and Disorders
- Renal Diseases and Glomerulopathies
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Tumors and Oncological Cases
- Bone Tumor Diagnosis and Treatments
- Skin Protection and Aging
- Ion channel regulation and function
- Infectious Diseases and Mycology
- Ear and Head Tumors
- Urinary and Genital Oncology Studies
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders
All India Institute of Medical Sciences Raipur
2016-2025
All India Institute of Medical Sciences Rishikesh
2017-2025
All India Institute of Medical Sciences Bhopal
2016-2025
Sambalpur University
2024
Sawai ManSingh Medical College and Hospital
2022-2024
Hektoen Institute
1998-2024
Cancer Institute (WIA)
2022-2024
Institute of Medical Sciences
2005-2023
Little Plumstead Hospital
2023
Hertfordshire Partnership University NHS Foundation Trust
2023
We evaluated the effects of novel benzimidazolone, 1-ethyl-2-benzimidazolinone (1-EBIO), on Cl- secretion across T84 monolayers. 1-EBIO stimulated a sustained secretory response at half-maximal effective concentration 490 microM. Charybdotoxin (CTX) inhibited 1-EBIO-induced short-circuit current (Isc) with an inhibitory constant (Ki) 3.6 nM, whereas 293B, inhibitor adenosine 3',5'-cyclic monophosphate-activated K+ channels, had no effect induced by 1-EBIO. In contrast, CTX failed to inhibit...
ABSTRACT Background To correlate between immunohistochemical expression of tumor‐infiltrating lymphocytes (TILs), tumor‐associated macrophages (TAMs), and natural killer (NK) cells with the AJCC 8th edition TNM staging system other disease‐modifying clinico‐pathological variables. Methods The representative histology sections tumor invasive margin (IM) core (TC) were selected according to International Immuno‐Oncology Biomarker Working Group subjected immunohistochemistry antibodies for TILs...
Himachal Pradesh, in the Indian Himalaya, has a rich diversity of medicinal plants, which are widely used. This paper brings together existing information with results from recent field surveys. A total 643 species plants identified; many different plant parts used for treatment various ailments. The number decreased increasing altitude. classified according to nativeness, endemism, and rarity, prioritized cultivation. Existing strategies in-situ ex-situ conservation, cultivation propagation...
Intravascular hemolysis and hemoglobinuria are associated with sickle cell nephropathy. ApoL1 is involved in cell-free hemoglobin scavenging through association haptoglobin-related protein. APOL1 G1/G2 variants the strongest genetic predictors of kidney disease general African-American population. A single report In 221 patients at University Illinois Chicago, we replicated finding an proteinuria, specifically urine albumin concentration (β=1.1, P=0.003), observed even stronger (OR=2.5,...
We evaluated the effects of clotrimazole and clofibrate on Ca(2+)- adenosine 3',5'-cyclic monophosphate (cAMP)-mediated Cl- secretion in colonic cell line, T84. used 1-ethyl-2-benzimidazolinone (1-EBIO) to activate Ca(2+)-dependent K+ channel (KCa) these cells induce a sustained secretory current (Isc). Clotrimazole potently inhibited KCa-dependent Isc, with an inhibition constant (Ki) 0.27 +/- 0.02 microM. Clofibrate also 1-EBIO-induced Isc albeit lower affinity (Ki = 6.5 1.2 microM). (10...
Epidermoid cysts, one of the common benign intradermal or subcutaneous tumors commonly result from trauma to pilosebaceous unit in hair bearing area. In areas without hair, these cysts are considered implantation and proliferation squamous epithelium into dermis due injury.The aim is evaluate clinicopathological details with emphasis on unusual findings related epidermoid cysts.This a retrospective cross-sectional study carried out over 2 years.A total 103 cases were included study. The...
Soni, Mayank; Bhatia, Shrutikant; Gupta, Sweety; Singh, Ashok; Manoj Author Information
This study presents a comprehensive assessment of faunal diversity on the University Rajasthan campus, critical green space in rapidly urbanizing city Jaipur, India. Through systematic observational surveys conducted over year 2024, we identified 109 species across 3 phyla, 5 classes, 29 order and 74 families, with Arthropoda dominating (73.5%), followed by Chordata (24.8%) Annelida (1.8%). The high arthropods, particularly pollinators like bees, underscores their ecological importance...
Introduction: Intraoperative cytology in ovarian tumors involves collecting cell samples from the sample sent during surgery and quickly examining them for diagnostic information. Frozen section provides rapid diagnosis to guide intraoperative patient management. The indications of frozen are identification tissue, evaluation margins lymph nodes metastasis. Aim: To evaluate comparative utility squash smear, scrape smear imprint with tumour. Materials methods: tissue clinico-radiologically...
The mainstay of treatment for ovarian cancer is surgery. To prevent under-treatment and overtreatment to choose the best surgical strategy patients with tumors, intraoperative pathological assessment essential. Frozen sections (FSs) have been historically used evaluation. In 1927, cytology was introduced by Dudgeon Patrick as a new method examination. Diagnosis can be made in minutes making smears from lesion, staining them quickly, analyzing under microscope. Following comprehensive search...
Short-term cyclosporine (CsA) has been shown to reduce the proteinuria in refractory nephrotic syndrome, but effect on disease progression not evaluated. This study was undertaken evaluate whether maintenance CsA therapy steroid-resistant focal segmental glomerulosclerosis (FSGS) will prevent ESRD. Twenty-one black and Hispanic children (mean age, 8.4 +/- 4.5 yr) with biopsy-proven, steroid/cyclophosphamide-resistant FSGS were treated (initiated at 6 mg/kg per day titrated serum cholesterol...
Abstract Prostate cancer continues to remain the most common and second leading cause of cancer-related deaths in American males. The Pten deletions and/or mutations are frequently observed both primary prostate cancers metastatic tissue samples. deletion epithelium mice results prostatic intraepithelial neoplasia (PIN), followed by progression invasive adenocarcinoma. conditional knockout [(Pten-loxp/loxp:PB-Cre4+) (Pten-KO)] provide a unique preclinical model evaluate agents for efficacy...
Abstract Context Glioblastoma multiforme (GBM) is a malignant and aggressive primary brain tumor with poor prognosis. This adverse prognosis due to the tumor's tendency for advancement recurrence caused by highly intrusive nature of persisting GBM cells that actively escape from main mass into surrounding normal tissue. On basis biomarker illustration, it can be classified molecular subgroups. Aims (1) To determine expression IDH1, ATRX, p53, Ki67 immunohistochemistry, in cohort GBMs. (2)...
We previously demonstrated that 1-ethyl-2-benzimidazolone (1-EBIO) directly activates basolateral membrane calcium-activated K(+) channels (K(Ca)), thereby stimulating Cl(-) secretion across several epithelia. In our pursuit to identify potent modulators of may be useful overcome the secretory defect in cystic fibrosis (CF), we have identified chlorzoxazone [5-chloro-2(3H)-benzoxazolone], a clinically used centrally acting muscle relaxant, as stimulator epithelial cell types, including T84,...
We evaluated effects of psoralens on Cl- secretion (short-circuit current, I(sc)) across T84 monolayers. Methoxsalen failed to increase I(sc). Several observations suggest that open cystic fibrosis transmembrane conductance regulator channels. 1) After activation the Ca2+-dependent basolateral membrane K+ channel (K(Ca)) by 1-ethyl-2-benzimidazolinone or thapsigargin, methoxsalen (10 microM) further increased 2) When added before carbachol (CCh), potentiated I(sc) response CCh, as predicted,...
// Ashok Singh 1 , Estelle Willems Anupama Bilal Bin Hafeez Irene M. Ong 2 Suresh L. Mehta 3 and Ajit Kumar Verma Department of Human Oncology, Wisconsin Institutes for Medical Research, Paul P. Carbone Comprehensive Cancer Center, School Medicine Public Health, University Wisconsin, Madison, WI, USA Biostatistics Informatics, Science Neurological Surgery, Correspondence to: Verma, email: Keywords : microRNA, TNFα, SCC, UVR Received November 04, 2015 Accepted January 29, 2016 Published...
Crude extracts and active principles from medicinal plants have shown potential role in controlling plant diseases glasshouses as well fields one of the safest ecofriendly methods. The effect nor-securinine (an alkaloid) isolated Phyllanthus amarus has been seen against spore germination some fungi (Alternaria brassicae, A. solani, Curvularia pennisetti, sp., Erysiphe pisi, Helminthosporium frumentacei) pea powdery mildew (Erysiphe pisi) under glasshouse conditions. sensitivity to varied...
Background/Aims The existing histological classifications for the interpretation of small intestinal biopsies are based on qualitative parameters with high intraobserver and interobserver variations. We have developed propose a quantitative classification system assessment mucosal biopsies. Methods performed computer-assisted digital images duodenal from 137 controls 124 patients celiac disease (CeD) (derivation cohort). From receiver-operating curve analysis, followed by multivariate...