A5080422672- Cardiac, Anesthesia and Surgical Outcomes
- Fungal Infections and Studies
- Patient Safety and Medication Errors
- Antifungal resistance and susceptibility
- COVID-19 and healthcare impacts
- Glioma Diagnosis and Treatment
- Polyomavirus and related diseases
- Cardiovascular Syncope and Autonomic Disorders
- Meningioma and schwannoma management
- EEG and Brain-Computer Interfaces
- Telemedicine and Telehealth Implementation
- Surgical Simulation and Training
- Takotsubo Cardiomyopathy and Associated Phenomena
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Medical Malpractice and Liability Issues
Stanford University
2023
Harvard University
2021-2022
Cohen Children's Medical Center
2021
Duke University Hospital
2018-2020
Duke Medical Center
2018-2020
Cryptococcal meningitis (CM) has emerged as the most common life-threatening fungal worldwide. Current management involves a sequential, longitudinal regimen of antifungals; despite significant improvement in survival compared with uniform mortality without treatment, this drug paradigm not led to consistent cure. Neurapheresis therapy, extracorporeal filtration yeasts from cerebrospinal fluid (CSF) infected hosts, is presented here novel, one-time therapy for CM. In vitro CSF through...
Cryptococcus spp., important fungal pathogens, are the leading cause of fungus-related mortality in human immunodeficiency virus-infected patients, and new therapeutic options desperately needed. Isavuconazonium sulfate, a newer triazole antifungal agent, was studied to characterize exposure-response relationship rabbit model cryptococcal meningoencephalitis. Rabbits treated with isavuconazonium sulfate were compared those fluconazole untreated controls.
In response to the coronavirus disease-2019 (COVID-19) pandemic, we developed and launched a student-led telemedicine program in Chelsea. From April November 2020, over 200 student volunteers contacted 1000 patients assess COVID-19 symptoms, provide counseling, triage patients. Through retrospective cohort study, determined that decision was associated with patient outcomes, including hospitalization status, test administration, result. These results quantify outcomes of clinic combat...
Leptomeningeal metastases (LM), late-stage cancer when malignant cells migrate to the subarachnoid space (SAS), have an extremely poor prognosis. Current treatment regimens fall short in effectively reducing SAS tumor burden. Neurapheresis therapy is a novel approach employing filtration and enhanced circulation of cerebrospinal fluid (CSF). Here, we examine vitro use neurapheresis as novel, adjunctive option for LM by filtering augmenting distribution drugs that may potential enhance...
Background Paroxysmal sympathetic hyperactivity (PSH) is an autonomic disorder affecting patients with severe acquired brain injury characterized by intermittent discharges limited therapeutic options. We hypothesized that the PSH pathophysiology could be interrupted via stellate ganglion blockade (SGB). Case presentation A patient after midbrain hemorrhage followed hydrocephalus obtained near-complete resolution of events for 140 days SGB. Conclusion SGB a promising therapy PSH, overcoming...
The aims of this study were to describe the process integrating 2 established training programs, Nontechnical skills for surgeons, and a traditional essential surgical course measure impact integrated on behaviors interprofessional teams in Rwandan district hospitals.Surgical errors resulting adverse events are due variability both technical nontechnical skills. Providing perioperative team may enhance learning these promote safe intraoperative patient care.A quality improvement framework...