A5038289717- Plant-Microbe Interactions and Immunity
- Plant nutrient uptake and metabolism
- Genetic Mapping and Diversity in Plants and Animals
- Plant Molecular Biology Research
- Bioinformatics and Genomic Networks
- Plant biochemistry and biosynthesis
- Plant Pathogenic Bacteria Studies
- Biofuel production and bioconversion
- Viral-associated cancers and disorders
- Plant Virus Research Studies
- Toxin Mechanisms and Immunotoxins
- Plant pathogens and resistance mechanisms
- Agricultural pest management studies
- Legume Nitrogen Fixing Symbiosis
- Microbial Natural Products and Biosynthesis
- Genetic and Environmental Crop Studies
- Microbial Metabolic Engineering and Bioproduction
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Genetics, Bioinformatics, and Biomedical Research
- Moringa oleifera research and applications
- Computational Drug Discovery Methods
- Cocoa and Sweet Potato Agronomy
- Lung Cancer Research Studies
- Advances in Cucurbitaceae Research
Indian Agricultural Statistics Research Institute
2022-2025
Indian Council of Agricultural Research
2022-2024
Government of India
2022
Indian Agricultural Research Institute
2022
Rice blast disease, instigated by Magnaporthe oryzae (M. oryzae), significantly impedes global rice production. Targeting the M. signaling protein, cAMP-Protein Kinase A (CPKA), which facilitates appressorium development and host penetration, this study explores potential inhibitory effects of natural compounds. Virtual screening, molecular docking text mining approaches were used to find nimonol curcumin that inhibit CPKA protein. The MM-PBSA method was do dynamics (MD) simulation binding...
Abstract Background Polygalacturonase inhibiting proteins (PGIPs) play a pivotal role in plant defense against pathogens by polygalacturonase (PG), an enzyme produced to degrade cell wall pectin. PGIPs, also known as leucine-rich repeat pathogenesis-related (PR) proteins, activate the host’s response upon interaction with PG, thereby reinforcing host attacks. In Egyptian or extra-long staple cotton ( Gossypium barbadense ), between PGIP and PG is one of crucial steps mechanism major such...
The recent emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the disease (COVID-19) has become a global public health crisis, and crucial need exists for rapid identification development therapeutic interventions. In this study, recurrent neural network (RNN) is trained optimized to produce ligands that could serve as potential inhibitors SARS-CoV-2 viral protease: 3 chymotrypsin-like protease (3CL pro ). Structure-based virtual screening was performed...
Despite advancements in agricultural research and the introduction of modern biotechnological farming techniques, food security remains a significant issue. Although efforts farmers to meet demands growing population, many plant diseases caused by pathogens, through their effects on cell division tissue growth, lead annual loss countless crops. The recently emerged wheat blast fungus
Chronic burn wounds are frequently characterised by a prolonged and dysregulated inflammatory phase that is mediated over-activation of NF-κB p65. Synthetic wound healing drugs used for treatment inflammation primarily associated with several shortcomings which reduce their therapeutic index. In this scenario, phytoconstituents exhibit multifaceted biological activities including anti-inflammatory effects have emerged as promising alternative. However, identification isolation from medicinal...
The cell wall of the Glycine max altered by polygalacturonases (PGs) secreted fungus Sclerotinia sclerotiorum, causes disease and quality losses. In soybeans, a resistance protein called polygalacturonases-inhibiting proteins (PGIPs) binds to PG block fungal infection. active site residues PGIP3, VAL170 GLN242 are mutated naturally various amino acids in different types PGIPs. Therefore, mutation GLY is ineffective but acid LYS significantly alters structure crucial for interacting with...
Ralstonia solanacearum is among the most damaging bacterial phytopathogens with a wide number of hosts and broad geographic distribution worldwide. The pathway phenotype conversion (Phc) operated by quorum-sensing signals modulated through (R)-methyl 3-hydroxypalmitate (3-OH PAME) in R. solanacearum. However, molecular structures Phc components are not yet established, structural consequences 3-OH PAME on quorum sensing well studied. In this study, 3D proteins (PhcA PhcR) were...
Although primary infection of Epstein-Barr virus is generally non-lethal, viral reactivation often associated with fatal outcomes. Regardless, there no FDA-approved treatment available for this omnipresent infection. The current investigation targets maintenance and by inhibiting the functioning deoxyuridine-triphosphatase (dUTPase) using phytochemicals. EBV-dUTPase essential maintaining nucleotide balance thus, plays a vital role in replication cycle. Additionally, protein has shown...
Enterotoxaemia (ET) is a severe disease that affects domestic ruminants, including sheep and goats, caused by Clostridium perfringens type B D strains. The characterized the production of Epsilon toxin (ETX), which has significant impact on farming industry due to its high lethality. binding ETX host cell receptor crucial, but still poorly understood. Therefore, structural features goat Myelin lymphocytic (MAL) protein were investigated defined in this study. We induced mutations aromatic...