A5012749262- Advanced Proteomics Techniques and Applications
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Cancer-related molecular mechanisms research
- Diabetes Treatment and Management
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Acute Myeloid Leukemia Research
- Genomics and Chromatin Dynamics
- Pancreatitis Pathology and Treatment
- Chronic Myeloid Leukemia Treatments
Universitat Autònoma de Barcelona
2013-2024
Histone H1 is involved in the regulation of chromatin structure and gene expression. Up to seven subtypes or variants are expressed human somatic cells. The complement, defined as subtype composition proportions a given cell, highly variable depending on cell type, cycle, developmental stage, several diseases such cancer. It result combined action different regulatory processes. Epitranscriptome modifications have emerged new mechanism able control all aspects mRNA metabolism. In this work,...
Histone H1 is involved in the regulation of chromatin structure. Human somatic cells express up to seven subtypes. The variability proportions H1s (H1 complement) one piece evidence supporting their functional specificity. Alterations protein levels different subtypes have been observed cancer, suggesting potential as biomarkers and that they might play a role disease development. We developed mass spectrometry-based (MS) parallel reaction monitoring (PRM) assay suitable for quantification...
Abstract Histone H1 is involved in chromatin compaction and dynamics. In human cells, the complement formed by different amounts of somatic subtypes, H1.0-H1.5 H1X. The amount each variant depends on cell type, cycle phase, time development can be altered disease. However, mechanisms regulating protein levels have not been described. We analyzed contribution proteasome to degradation subtypes cells using two inhibitors: MG132 bortezomib. accumulate upon treatment with both drugs, indicating...