A5044805724- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Myasthenia Gravis and Thymoma
- Diabetes and associated disorders
- Regulation of Appetite and Obesity
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
- IgG4-Related and Inflammatory Diseases
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Retinoids in leukemia and cellular processes
- Pluripotent Stem Cells Research
- Liver physiology and pathology
- Muscle Physiology and Disorders
- Soft tissue tumor case studies
- Immunodeficiency and Autoimmune Disorders
Kobe University
2015-2025
Konan Women's University
2024-2025
Kobe University Hospital
2015-2024
Diabetes Australia
2013
Kagawa Prefectural Central Hospital
2010
National Institute of Environmental Health Sciences
2008-2009
National Institutes of Health
2009
Molecular Oncology (United States)
2004
Liver dysfunction in adult hypopituitary patients with GH deficiency (GHD) has been reported and an increased prevalence of nonalcoholic fatty liver disease (NAFLD) suggested. The objective the present study was to elucidate pathophysiology GHD. We recruited 69 consecutive Japanese GHD examined NAFLD by ultrasonography steatohepatitis (NASH) biopsy. Patients had given routine replacement therapy except for GH. compared these healthy age-, gender-, BMI-matched controls. further analyzed...
Although various function of chemerin have been suggested, its physiological role remains to be elucidated. Here we show that chemerin-deficient mice are glucose intolerant irrespective exhibiting reduced macrophage accumulation in adipose tissue. The intolerance was mainly due increased hepatic production and impaired insulin secretion. Chemerin receptor ChemR23 were expressed β-cell. Studies using isolated islets perfused pancreas revealed glucose-dependent secretion (GSIS) mice....
Abstract Hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and cirrhosis determines patient prognosis; however, effective treatment for has not been established. Oxidative stress inflammation activate hepatic stellate cells (HSCs) promote fibrosis. In contrast, cellular senescence inhibits HSCs’ activity limits The aim of this study was to explore the effect IGF-I on NASH cirrhotic models clarify underlying mechanisms. We demonstrate that significantly ameliorated steatosis,...
The pituitary-specific transcriptional factor-1 (PIT-1, also known as POU1F1), is an essential factor for multiple hormone-secreting cell types. A genetic defect in the PIT-1 gene results congenital growth hormone (GH), prolactin (PRL), and thyroid-stimulating (TSH) deficiency. Here, we investigated 3 cases of adult-onset combined GH, PRL, TSH deficiencies found that endocrinological phenotype each was linked to autoimmunity directed against protein. We detected anti-PIT-1 antibody along...
IGF-I induces skeletal muscle hypertrophy by stimulating protein synthesis and suppressing the degradation pathway; downstream signaling pathways Akt-mammalian target of rapamycin (mTOR)-p70-kDA-S6-kinase (p70S6K), Forkhead box O1 (FoxO1) play essential roles in this regulation. Reactive oxygen species (ROS) modulate various growth factors via redox However, role ROS is not fully understood. In study, we investigated whether regulate biological action C2C12 myocytes. We found that While...
Pituitary develops from oral ectoderm in contact with adjacent ventral hypothalamus. Impairment this process results congenital pituitary hypoplasia (CPH); however, there have been no human disease models for CPH thus far, prohibiting the elucidation of underlying mechanisms. In study, we established a model using patient-derived induced pluripotent stem cells (iPSCs) and 3D organoid technique, which hypothalamus develop simultaneously. Interestingly, patient iPSCs heterozygous mutation...
Immune checkpoint inhibitors (ICIs) as a cancer immunotherapy have emerged treatment for multiple advanced types. Because of enhanced immune responses, immune-related adverse events (irAEs), including endocrinopathies such hypophysitis, been associated with the use ICIs. Most underlying mechanisms ICI-related hypophysitis remain unclear, especially programmed cell death-1 (PD-1)/PD-1 ligand 1 (PD-L1) inhibitors. We hypothesized that is paraneoplastic syndrome caused by ectopic expression...
Abstract We investigated the utility of branched‐chain amino acids (BCAA) in dexamethasone‐induced muscle atrophy. Dexamethasone (600 μg/kg, intraperitoneally) and/or BCAA mg/kg, orally) were administered for 5 days rats, and effect on atrophy was evaluated. decreased total protein concentration rat soleus muscles. Concomitant administration reversed decrease. mean cross‐sectional area fibers, which by BCAA. increased atrogin‐1 expression, has been reported to play a pivotal role The...
Adaptation under fasting conditions is critical for survival in animals. Sirtuin 1 (SIRT1), a protein deacetylase, plays an essential role adaptive metabolic and endocrine responses by modifying the acetylation status of various proteins. Fasting induces growth hormone (GH) resistance liver, leading to decreased serum insulin-like factor-I (IGF-I) levels as adaptation malnutrition; however, underlying mechanisms this action remain be fully elucidated. Here we report that vivo knockdown SIRT1...
Although somatostatin analogues are effective medical therapy for acromegaly, the serum insulin-like growth factor-I (IGF-I) levels remain uncontrolled in 35% of patients. Combined with octreotide LAR and cabergoline has been reported to normalize IGF-I 42-56% Caucasian patients acromegaly. However, it remains be clarified whether combination is Japanese on tumor shrinkage. We conducted a retrospective study combined octreotide-resistant Ten acromegaly who showed octreotide-resistance were...
Cancer immunotherapy has emerged as treatment of multiple advanced cancer types. Immune checkpoint inhibitors, namely anticytotoxic T-lymphocyte antigen-4 (CTLA-4), antiprogrammed cell death-1 (PD-1), and ligand 1 (PD-L1) antibodies, have been used for various cancers. Classified immune-related adverse events, several endocrinopathies, including hypophysitis, are associated with these agents. Although anti-CTLA-4-induced hypophysitis frequently observed, upon use anti-PD-1 anti-PD-L1...
Pheochromocytoma and paraganglioma are catecholamine-producing tumors that often impair glucose tolerance. The effects of these on insulin sensitivity secretion in patients have remained unclear, however. To characterize the influence pheochromocytoma or tolerance, we comprehensively analyzed various parameters related to with tumors. Hyperglycemic hyperinsulinemic-euglycemic clamps, as well an oral tolerance test (OGTT), were performed before after tumor excision. Patients underwent...
Immune checkpoint inhibitor (ICI)-related hypophysitis (RH) is a common immune-related adverse event. The early detection of ICI-RH prevents life-threatening adrenal insufficiency. However, good predictors secondary insufficiency in have not yet been reported. We hypothesized that fluctuations plasma adrenocorticotropic hormone (ACTH) and cortisol levels occur similarly to those thyroid-stimulating thyroid (thyroxine triiodothyronine) ICI-related thyroiditis. Here, we sought test this...
Chemerin, a recently discovered adipocytokine plays an important role in obesity and obesity-associated metabolic complications. However, the of chemerin pathogenesis type 2 diabetes mellitus (T2DM) has not fully been elucidated. We compared serum levels parameters between 88 control subjects, 86 patients with syndrome (MS), 147 T2DM Japanese population further analyzed their correlation. Enzyme-linked immunosorbent assay was used to measure levels. The were significantly higher male than...
Objective Patients with acromegaly exhibit reduced life expectancy and increased prevalence of age-related diseases, such as diabetes, hypertension, cardiovascular disease. However, the underlying mechanism has not been fully elucidated. Telomere shortening is reportedly associated these diseases. Methods We measured telomere length in patients using quantitative PCR method. The effect GH IGF-I on cellular senescence was examined human skin fibroblasts. Results exhibited shorter than age-,...