It does get in! A fluoride-assisted direct cross-coupling of cyclic enamides with trialkoxy aryl silanes by a palladium-catalyzed C--H activation leads to wide range in yields up 95 %.

An efficient methodology for oxidative cross-coupling reaction of olefins with acrylates catalyzed by palladium(II) was developed. The corresponding dienoates were obtained in moderate to good yields.

A Ru-catalyzed direct oxidative cross-coupling reaction of acrylates was developed. It offers a straightforward and atom-economical protocol for the synthesis functionalized (Z,E)-muconate derivatives in moderate to good yields with stereo- chemoselectivities. The conjugated muconates bearing differentiable terminal functionality can be selectively transformed into versatile synthetic intermediates widely used organic synthesis.

Diverse and controllable pathways induced by palladium-catalyzed intramolecular Heck reaction of N-vinylacetamides for the synthesis nitrogen-containing products in reasonable to high yields via tuning phosphine ligands bases are reported. Domino reactions including unique β-N-Pd elimination, 1,4-Pd migration, or direct acyl C-H bond functionalization were found be involved forming different products, respectively. Given ability using same starting material generate diverse completely...

Z only: An atom-economical synthetic route towards arylated Z-enamides through double CH functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation absolute (step A in scheme), and molecular complexity products can be further endowed by a sequential second arylation, which requires use trifluoracetic acid (TFA; step B). realm transition-metal-catalyzed cross-coupling reactions1 has traditionally depended on prefunctionalized substrates for both reactivity...

A six-membered cyclic vinylpalladium complex was synthesized via alkenyl C–H bond direct palladation, which probed in detail by 1H NMR spectroscopy and characterized X-ray analysis. The propounded to be the intermediate during olefination reaction of enamides. An efficient catalytic system for oxidative cross-coupling enamides with electron-deficient olefins catalyzed palladium(II) acetate 1 atm oxygen as sole oxidant developed. corresponding products were obtained moderate good yields under...

Copper-catalyzed highly efficient hydrosilylation reaction of enynoates was developed. Under simple conditions, various di-, tri-, and tetrasubstituted racemic allene products could be obtained in high yields. The asymmetric 1,6-addition silyl group to the (Z)-2-alken-4-ynoates achieved under mild conditions afford silyl-substituted enantioenriched chiral good yields with enantioselectivities.

An efficient rhodium(III)-catalyzed C–H bond activation and further direct arylation of (hetero)arenes with organosilanes in aqueous media was developed. This reaction shows good substrate scope excellent functional group compatibility gives the products yields regioselectivity.

A RhIII -catalyzed intramolecular oxidative cross-coupling between double bonds for the synthesis of macrolides is described. Under optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo- stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds 1,3-conjugated structure.

The Cu-catalyzed 1,4-protosilylation and protoborylation of trifluoromethyl-substituted conjugated enynes were developed to access functionalized homoallenylsilanes homoallenylboronates. This protocol also provides a general method synthesize optically active homoallenylboronates in moderate excellent yields with high enantiomeric excess by using new designed chiral bisoxazoline ligands. Simultaneously, the transformations explored useful building blocks.

A copper-catalyzed regiodivergent hydrosilylation of a wide range simple allenes is reported. Linear and branched allylsilanes were formed by judicious choice solvents. Furthermore, obtained with high enantioselectivity (up to 97% enantiomeric excess) the aid C2-symmetric bisphosphine ligand in unprecedented asymmetric allene hydrosilylation.

A new direct coupling of cyclic enamides with aryl boronic acids viaPd(II)-catalyzed C–H functionalization has been achieved good yields (up to 90%).

Abstract A hydroxy group chelation‐assisted stereospecific oxidative cross‐coupling reaction between alkenes was developed under mild conditions. In the presence of palladium catalyst, tethered with functionality can couple efficiently electron‐deficient to form corresponding multi‐substituted olefin products. The on substrate could play dual roles in reaction, acting as directing for alkenyl C−H bond activation and controlling stereoselectivity

Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic reacted well to afford the corresponding multi-substituted alkene products in good yields. The coupling could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl γ-lactam derivatives.

The results from a direct palladium-catalyzed cross-coupling reaction between variety of olefins with acrylate through vinylic C–H activation that give the corresponding butadienes in moderate to good yields and stereoselectivities are reported. Given reaction's ability tolerate wide range styrenes, aliphatic alkenes acrylates, this atom- step-economical methodology offers straightforward method forge new C–C bonds valuable diene products readily available starting materials under very mild...

A synthetic method of copper-catalyzed silylperoxidation α,β-unsaturated carbonyl compounds and conjugated enynes has been developed. The realization the carbon–carbon double bond permits direct access to silicon-containing peroxy products in moderate good yields. Furthermore, this protocol distinguishes itself by operational simplicity exhibiting tolerance a wide scope functional groups. This strategy provides an efficient approach 1,2-difunctionalization enynes.

A novel strategy of copper-catalyzed regio- and enantioselective hydrosilylation 4-substituted vinylidenecyclohexanes with silanes was developed. In this protocol, various allenes were used to afford the corresponding (cyclohexylidene)ethyl in moderate high yields good enantioselectivities.

We report a copper-catalyzed ligand-controlled selective 1,2- and 1,4-hydrosilylation of 1,3-enynes, which furnishes enantiomerically enriched propargyl- 1,2-allenylsilane products in high yields with excellent enantioselectivities (up to 99% ee). This reaction proceeds under mild conditions, shows broad substrate scope for both 1,3-enynes trihydrosilanes, displays regioselectivities. Mechanistic studies based on deuterium-labeling reactions density functional theory (DFT) calculations...

Abstract A direct ethynylation reaction between N ‐vinylacetamides and (bromoethynyl)triisopropylsilane catalyzed by palladium is reported. broad scope of cyclic ‐vinylacetamide derivatives was tolerated the corresponding products could be obtained in acceptable yields. This work provides a general tool for synthesis conjugated enyne using palladium(II) acetate as catalyst. The mild conditions reasonable results should make this method useful synthetic protocol. Unfortunately, other...

An efficient and general copper(I)-catalyzed method for the synthesis of multi-substituted vinylsilanes is reported. Multi-substituted allenes with electron-withdrawing groups propiolate derivatives reacted well (dimethylphenylsilyl)boronic acid pinacol ester to afford silyl-substituted butenoate β-silyl-substituted acrylate derivatives, respectively. The corresponding products could be obtained in moderate high yields good excellent stereoselectivities.

A cyclization reaction between enamides and alkynes catalyzed by palladium(<sc>ii</sc>) acetate is described. In this method, the molecular oxygen serves as an efficient oxidant for Pd(<sc>ii</sc>)/Pd(0) catalytic cycle. The simple conditions permit methodology to be used a general tool preparation of multi-substituted pyrroles.

Lewis acid B(C6F5)3 catalyzed the Diels-Alder reactions of multisubstituted open-chain dienes and α,β-enals to afford desired products with high exo-selectivities are reported. The substituent effect dienophiles on product's stereoselectivity was thoroughly investigated, it found that most exo-Diels-Alder could be obtained in good yields exo-stereoselectivities.

An efficient iron(II)-catalyzed alkoxycarbonylation reaction between N-vinylacetamides and carbazates is reported. The corresponding useful highly substituted (β-acylamino)acrylates could be obtained in reasonable to good yields stereoselectivity under mild conditions.