A5073370938- Catalytic C–H Functionalization Methods
- Organoboron and organosilicon chemistry
- Catalytic Cross-Coupling Reactions
- Asymmetric Synthesis and Catalysis
- Cyclopropane Reaction Mechanisms
- Catalytic Alkyne Reactions
- Synthetic Organic Chemistry Methods
- Synthesis and characterization of novel inorganic/organometallic compounds
- Radical Photochemical Reactions
- Food Quality and Safety Studies
- Oxidative Organic Chemistry Reactions
- Advanced Synthetic Organic Chemistry
- Asymmetric Hydrogenation and Catalysis
- Sulfur-Based Synthesis Techniques
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Reactions
University of Science and Technology of China
2014-2019
Hefei University
2017
Abstract A hydroxy group chelation‐assisted stereospecific oxidative cross‐coupling reaction between alkenes was developed under mild conditions. In the presence of palladium catalyst, tethered with functionality can couple efficiently electron‐deficient to form corresponding multi‐substituted olefin products. The on substrate could play dual roles in reaction, acting as directing for alkenyl C−H bond activation and controlling stereoselectivity
Abstract A direct ethynylation reaction between N ‐vinylacetamides and (bromoethynyl)triisopropylsilane catalyzed by palladium is reported. broad scope of cyclic ‐vinylacetamide derivatives was tolerated the corresponding products could be obtained in acceptable yields. This work provides a general tool for synthesis conjugated enyne using palladium(II) acetate as catalyst. The mild conditions reasonable results should make this method useful synthetic protocol. Unfortunately, other...
Lewis acid B(C6F5)3 catalyzed the Diels-Alder reactions of multisubstituted open-chain dienes and α,β-enals to afford desired products with high exo-selectivities are reported. The substituent effect dienophiles on product's stereoselectivity was thoroughly investigated, it found that most exo-Diels-Alder could be obtained in good yields exo-stereoselectivities.
A palladium-catalyzed intramolecular amination of alkenes with retention olefin functionalization was achieved under mild reaction conditions. In the presence palladium catalyst, tosyl-protected amine can directly couple a double bond to provide versatile dihydropyrrole derivatives in moderate excellent yields.
A copper-catalyzed double proto-silylations of electron-deficient conjugated enynes to synthesize functional bis(silyl)propenes was developed. Under mild reaction conditions, the silylboronate PhMe2Si-Bpin reacts with via cascade and yields corresponding Z-specific bis(silyl)propene products in up 98% yield 95% ee. In addition, enantioselective synthesis these compounds also achieved by using enantiopure pyridine-oxazoline-based ligand.
Copper-catalyzed divergent conjugate protosilylation and protoborylation of polar enynes were developed. The corresponding β-boryldienoates β-silyldienotes obtained in moderate to good yields with stereoselectivity. In this protocol, novel cascade double protoborylation/protodeboronation processes enynoates enabled access the useful trisubstituted vinylboronates up 80% yield 98:2 Z/ E ratio. Moreover, transformations products thus also investigated.
A general strategy for the hydroalkylation of vinyl ketones using ethers catalyzed by an iron catalyst is described.
A hydroxy group chelation-assisted stereospecific oxidative cross-coupling reaction between alkenes was developed under mild conditions. In the presence of palladium catalyst, tethered with functionality can couple efficiently electron-deficient to form corresponding multi-substituted olefin products. The on substrate could play dual roles in reaction, acting as directing for alkenyl C−H bond activation and controlling stereoselectivity
Abstract Various N‐vinylacetamides undergo Pd‐catalyzed coupling with bromoalkyne (II) to afford the corresponding alkynylated products in good yields.
Abstract The remarkable exo‐selectivities of most the products may be due to steric interaction between bulky Lewis acid and substrates.