A5030755813- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Microbial Community Ecology and Physiology
- HIV Research and Treatment
- Animal Virus Infections Studies
- Genomics and Phylogenetic Studies
- Insect symbiosis and bacterial influences
- Viral Infections and Vectors
- CRISPR and Genetic Engineering
- RNA regulation and disease
- Viral Infections and Immunology Research
- Mitochondrial Function and Pathology
- vaccines and immunoinformatics approaches
- Erythrocyte Function and Pathophysiology
- Biochemical and Molecular Research
- Studies on Chitinases and Chitosanases
- Malaria Research and Control
- Viral gastroenteritis research and epidemiology
- RNA Research and Splicing
- Immune Response and Inflammation
- Viral Infectious Diseases and Gene Expression in Insects
- Bacteriophages and microbial interactions
- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
Mayo Clinic in Arizona
2025
University of California, Davis
2020-2024
University of California, Los Angeles
2022
Abstract Introduction: High-grade gliomas (HGG) are aggressive brain tumors with heterogeneous cell populations, including invasive regions driving disease progression and recurrence. Our previous work integrated molecular profiling spatially matched advanced multiparametric MRI in a cohort of HGG patients multi-regional sampling, uncovering distinct biological signatures linked to individual phenotypes. Yet, the relationships between phenotypes—and how this potentially informs underlying...
Dengue virus (DENV) disruption of the innate immune response is critical to establish infection. DENV non-structural protein 5 (NS5) plays a central role in this disruption, such as antagonism STAT2. We recently found that serotype 2 (DENV2) NS5 interacts with Polymerase associated factor 1 complex (PAF1C). The primary members PAF1C are PAF1, LEO1, CTR9, and CDC73. This nuclear an emerging player response. It promotes expression many genes, including genes related antiviral, antimicrobial...
Macroautophagy/autophagy is increasingly implicated in a variety of diseases, making it an attractive therapeutic target. However, many aspects autophagy are not fully understood and its impact on diseases remains debatable context-specific. The lack systematic dynamic measurements these cases key reason for this ambiguity. In recent years, Loos et al. 2014 Beesabathuni 2022 developed methods to quantitatively measure holistically. commentary, we pose some the unresolved biological questions...
SARS-CoV-2 Spike is a key protein that mediates viral entry into cells and elicits antibody responses. Its importance in infection, diagnostics, vaccinations has created large demand for purified clinical research applications. difficult to express, prompting modifications the expression platforms improve yields. Alternatively, receptor-binding domain (RBD) commonly expressed with higher titers, though it lower sensitivity serological assays. Here, we transient Chinese hamster ovary (CHO)...
Abstract Dengue virus (DENV) disruption of the innate immune response is critical to establish infection. DENV non-structural protein 5 (NS5) plays a central role in this disruption, such as antagonism STAT2. We recently found that serotype 2 (DENV2) NS5 interacts with Polymerase associated factor 1 complex (PAF1C). The primary members PAF1C are PAF1, LEO1, CTR9 and CDC73. This nuclear an emerging player response. It promotes expression many genes, including genes related antiviral,...
Halophile-specific enzymes have wide-ranging industrial and commercial applications. Despite their importance, there is a paucity of available halophile whole-genome sequences. Here, we report the draft genome sequences 16 diverse salt-tolerant strains bacteria archaea isolated from variety high-salt environments.
Abstract Zika virus (ZIKV) is infamous among flaviviruses for its unique association with congenital birth defects, notably microcephaly. We previously mapped ZIKV-host protein interactions and identified the interaction between ZIKV NS4A host ANKLE2, which itself has established ties to In fruit flies, induces microcephaly phenotypes in an ANKLE2-dependent manner. This suggests that interacts ANKLE2 dysregulate cell behavior contributes abnormal neurodevelopment. Here, we explore role of...
Sitting at the interface of gene expression and host-pathogen interaction, polymerase associated factor 1 complex (PAF1C) is a rising player in innate immune response. The localizes to nucleus associates with chromatin modulate RNA II (RNAPII) elongation transcripts. Performing this function both proximal distal regulatory elements, PAF1C interacts many host factors across such sites, along several microbial proteins during infection. Therefore, translating ubiquity into specific impacts on...
Abstract Background Sitting at the interface of gene expression and host-pathogen interaction, polymerase associated factor 1 complex (PAF1C) is a rising player in innate immune response. The localizes to nucleus associates with chromatin modulate RNA II (RNAPII) elongation transcripts. Performing this function both proximal distal regulatory elements, PAF1C interacts many host factors across such sites, along several microbial proteins during infection. Therefore, translating ubiquity into...
Abstract SARS-CoV-2 Spike is a key protein that mediates viral entry into cells and elicits antibody responses. Its importance in infection, diagnostics, vaccinations has created large demand for purified clinical research applications. difficult to express, prompting modifications the expression platforms improve yields. Alternatively, receptor binding domain (RBD) commonly expressed with higher titers, though it lower sensitivity serological assays. Here, we transient Chinese hamster ovary...