A5012253925- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Microbial Community Ecology and Physiology
- Light effects on plants
- Genomics and Phylogenetic Studies
- Protein Structure and Dynamics
- Veterinary medicine and infectious diseases
- Enzyme Structure and Function
- Protein Kinase Regulation and GTPase Signaling
- Bacteriophages and microbial interactions
- Enzyme Production and Characterization
- Galectins and Cancer Biology
- Bioenergy crop production and management
- Turfgrass Adaptation and Management
Cornell University
2025
University of California, Davis
2016-2021
Abstract Cryptochromes (CRYs) are evolutionarily conserved photoreceptors that mediate various light-induced responses in bacteria, plants, and animals. Plant cryptochromes govern a variety of critical growth developmental processes including seed germination, flowering time entrainment the circadian clock. CRY’s photocycle involves reduction their flavin adenine dinucleotide (FAD)-bound chromophore, which is completely oxidized dark semi to fully reduced light signaling-active state....
K-RAS mutations drive oncogenesis in multiple cancers, yet the lack of druggable sites has long hindered therapeutic development. Here, we use multi-temperature X-ray crystallography (MT-XRC) to capture functionally relevant conformations across a temperature gradient, spanning cryogenic physiological and even "fever" conditions, show how conditions may obscure key dynamic states as targets for new drug This approach revealed temperature-dependent conformational landscape K-RAS, shedding...
Abstract Expression of the Helicobacter pylori blood group antigen binding adhesin A (BabA) is more common in strains isolated from patients with peptic ulcer disease or gastric cancer, rather than asymptomatic colonization. Here we used mouse models to examine host determinants that affect H. BabA expression. expression was lost by phase variation as frequently WT mice RAG2−/− do not have functional B T cells, and MyD88−/−, TLR2−/− TLR4−/− are defective toll like receptor signaling. The...
Helicobacter pylori commonly infects the epithelial layer of human stomach and in some individuals causes peptic ulcers, gastric adenocarcinoma or lymphoma. is a genetically diverse species, most important bacterial virulence factor that increases risk developing disease, versus asymptomatic colonization, cytotoxin associated gene pathogenicity island (cagPAI). Socially housed rhesus macaques are often naturally infected with H. similar to which colonizes humans, but little known about...
Halophile-specific enzymes have wide-ranging industrial and commercial applications. Despite their importance, there is a paucity of available halophile whole-genome sequences. Here, we report the draft genome sequences 16 diverse salt-tolerant strains bacteria archaea isolated from variety high-salt environments.
Abstract Cryptochromes (CRYs) are evolutionarily conserved photoreceptors that mediate various light-induced responses in bacteria, plants, and animals. Plant cryptochromes govern a variety of critical growth developmental processes including seed germination, flowering time entrainment the circadian clock. CRY’s photocycle involves reduction their flavin adenine dinucleotide (FAD)-bound chromophore, which is completely oxidized dark semi to fully reduced light signaling-active state....