A5054835599- Endodontics and Root Canal Treatments
- Dental Radiography and Imaging
- Oral microbiology and periodontitis research
- Dental Trauma and Treatments
- Drilling and Well Engineering
- Helicobacter pylori-related gastroenterology studies
- Bone and Dental Protein Studies
- Burn Injury Management and Outcomes
- Eosinophilic Esophagitis
- Periodontal Regeneration and Treatments
- dental development and anomalies
- Galectins and Cancer Biology
- Wound Healing and Treatments
Karolinska Institutet
2025
Umeå University
2017-2024
Wound healing is a complicated biological process that consist of partially overlapping inflammatory, proliferation and tissue remodelling phases. A successful wound depends on proper activation subsequent termination the inflammatory phase. The failure to terminate inflammation halts completion known reason for formation chronic wounds. Previous studies have shown closure delayed in plasminogen-deficient mice, role plasminogen dissection extracellular matrix was suggested. However, our...
This prospective cohort study evaluates clinical and radiographical outcomes of endodontic pulp revitalization (PR) traumatized necrotic incisors.
Aim: To compare differences in the disinfection efficacy of calcium hydroxide (CH) and chlorhexidine gluconate (CHD) dressings pulp revitalization (PR) traumatized immature necrotic teeth; to investigate microflora successful/failed PR whether bacterial persistence influences outcomes PR.Methods: Microbiological assessment average load (CFU/sample) diversity (taxa/sample) was performed on 41 teeth at three timepoints (S2-before, S3-after debridement S5-after root canal dressing).Results: The...
ABSTRACT Introduction Regenerative endodontic treatment (RET) aims to promote root maturation in necrotic immature teeth, where effective microbial disinfection is crucial for success. This study evaluated the effect of calcium hydroxide (CH) and 2% chlorhexidine gluconate (CHD) as intracanal medicaments their impact on bacterial loads RET outcomes. Methods The material consisted samples from 41 patients who participated a previously conducted randomized controlled clinical trial comparing...
Abstract Expression of the Helicobacter pylori blood group antigen binding adhesin A (BabA) is more common in strains isolated from patients with peptic ulcer disease or gastric cancer, rather than asymptomatic colonization. Here we used mouse models to examine host determinants that affect H. BabA expression. expression was lost by phase variation as frequently WT mice RAG2−/− do not have functional B T cells, and MyD88−/−, TLR2−/− TLR4−/− are defective toll like receptor signaling. The...
Traumatic dental injuries in young individuals are often exposed to the invasion of oral microorganisms that leads pulp necrosis. Infective necrosis permanent teeth not-fully-developed causes aberrant root formation. Regeneration endodontic treatments (RETs) have shown promising results by promoting continued development stem cells. Critical success RET is thorough disinfection pulpal space. To establish effective antimicrobial protocols for canal disinfection, invading need be identified....
The use of stem cells from the apical papilla (SCAPs) has been proposed as a means promoting root maturation in permanent immature teeth, and plays significant role regenerative dental procedures. However, SCAPs may be compromised by microenvironmental factors, such hypoxic conditions presence bacteria infected canals. We aim to investigate oral bacterial modulation SCAP terms binding capacity using flow cytometry imaging, real-time cell proliferation monitoring, cytokine secretion (IL-6,...
Interaction of oral bacteria with stem cells from the apical papilla (SCAP) can negatively affect success regenerative endodontic treatment (RET). Through RNA-seq transcriptomic analysis, we studied effect Fusobacterium nucleatum and Enterococcus faecalis, as well their supernatants enriched by bacterial metabolites, on osteo- dentinogenic potential SCAPs in vitro. We performed bulk RNA-seq, basis which differential expression analysis (DEG) gene ontology enrichment (GO) were performed. DEG...
Stem cells from the apical papilla (SCAP) are a promising resource for use in regenerative endodontic treatment (RET) that may be adversely affected by oral bacteria, which turn can exert an effect on success of RET. Our work aims to study cytokine profile SCAP upon exposure bacteria and their supernatants-Fusobacterium nucleatum Enterococcus faecalis-as well as establish osteogenic immunogenic potentials SCAP. Further, we target presence key proteins Wnt/β-Catenin, TGF-β, NF-κB signaling...
Introduction Bacterial persistence is considered one of the main causal factors for regenerative endodontic treatment (RET) failure in immature permanent teeth. This interference claimed to be caused by interaction bacteria that reside root canal with stem cells are essentials RET. The aim study was investigate whether prolonged exposure from apical papilla (SCAP) bacterial remnants Fusobacterium nucleatum, Actinomyces gerensceriae, Slackia exigua, Enterococcus faecalis,...