A5046685948- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- Synthesis of Tetrazole Derivatives
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- HIV/AIDS drug development and treatment
- Chemical Synthesis and Analysis
- Computational Drug Discovery Methods
- Microwave-Assisted Synthesis and Applications
- Crystallography and molecular interactions
- Dyeing and Modifying Textile Fibers
- Perovskite Materials and Applications
- TiO2 Photocatalysis and Solar Cells
- Energetic Materials and Combustion
- Advanced Photocatalysis Techniques
- Catalytic C–H Functionalization Methods
- Synthesis of heterocyclic compounds
- Quinazolinone synthesis and applications
Karnatak University
2017-2022
University of Mysore
2017
Abstract Mild and efficient synthesis of 5‐methyl‐4‐[(2 Z )‐4‐(2‐oxo‐2 H ‐chromen‐3‐yl)‐2‐(4‐arylimino)thiazol‐3(2 )‐yl]‐2‐(4‐aryl)‐2 ‐1,2,4‐triazol‐3(4 )‐ones 7(h–s ) has been developed using microwave assisted multicomponent route. The molecular structures these novel compounds were characterized the photophysical thermal properties investigated elaborately absorption, fluorescence, fluorescence decay lifetimes thermo gravimetric analysis. Solvatochromism was studied as a function polarity...
Abstract Coumarin‐3‐yl‐methyl‐1,2,3‐triazolyl‐1,2,4‐triazol‐3(4 H )‐ones ( 8k‐z ) were synthesized via copper(I)‐catalyzed azide‐alkyne cycloaddition click chemistry. The hybrid molecules characterized by spectral studies. Compounds screened for their in vitro anti‐TB activity using the Microplate Alamar Blue assay and cytotoxicity MTT assay. Some of compounds found to be most potent against tested Mycobacterium tuberculosis H37Rv strain with a MIC 1.60 µg/ml. Further, docking into InhA...
Abstract A new series quinoline‐2 H ‐1,2,4‐triazol‐3(4 )‐ones 7 g‐n and 11 were designed synthesized. Docking studies of title compounds with DNA (PDB: 1AU5) long‐chain enoyl‐acyl carrier protein reductase (InhA) enzyme (PDB ID: 4TZK) as anticancer antitubercular targets showed good insights on the possible interactions. Further, tested for in vitro activity against HeLa human cervix tumor cell line also M. tuberculosis H37Rv [MTB] (ATCC‐27294). Some exhibited promising activities both...
Abstract A series of novel coumarin pyrazoline moieties combined with tetrazoles, 3‐(1‐phenyl‐4‐(1H‐tetrazol‐5‐yl)‐1H‐pyrazol‐3‐yl)‐2H‐chromen‐2‐one , 6‐chloro‐3‐(1‐phenyl‐4‐(1H‐tetrazol‐5‐yl)‐1H‐pyrazol‐3‐yl)‐2H‐chromen‐2‐one 6‐bromo‐3‐(1‐phenyl‐4‐(1H‐tetrazol‐5‐yl)‐1H‐pyrazol‐3‐yl)‐2H‐chromen‐2‐one and 6‐bromo‐3‐(1‐(4‐bromophenyl)‐4‐(1H‐tetrazol‐5‐yl)‐1H pyrazol‐3‐yl)‐2H‐chromen‐2‐one 7(a‐d), were designed synthesized. Single crystal X‐ray diffraction their interactions studied by...
The present study describes, the X-ray single crystal analysis of 4-((2-chloro-6-methoxyquinolin-3-yl)methyl)-2-phenyl-2H-1,2,4-triazol-3(4H)-one (TMQ). data for C19H15ClN4O2: monoclinic, space group P21/n (no. 14), a = 7.3314(15) Å, b 12.459(3) c 18.948(4) β 98.322(9)°, V 1712.5(6) Å3, Z 4, T 296.15 K, μ(MoKα) 0.245 mm-1, Dcalc 1.423 g/cm3, 5082 reflections measured (3.926° ≤ 2Θ 38.556°), 1428 unique (Rint 0.0545, Rsigma 0.0574) which were used in all calculations. final R1 was 0.0423 (I...
A simple and convenient approach for the synthesis of pyrazolyl-tetrahydroindazolones via L-proline catalyzed three component domino reaction arylhydrazine, dimedone pyrazole aldehyde in polyethyleneglycol-400 (PEG-400) under microwave irradiation is described. This novel green protocol proceeds smoothly good to excellent yields provides several advantages such as shorter time, metal-free conditions, work-up procedures. Also, recycling catalyst solvent was observed without loss activity (03) runs.
Microwave-assisted green approach is developed for an efficient synthesis of thiazol-2-imines under catalyst-free conditions. The desired products are formed by one-pot three-component reaction which improvised method Hantzsch thiazole synthesis. microwave-assisted protocol gives excellent yields with high purity in just 10–15 min. All the synthesized compounds have been screened antifungal activity and some derivatives show a broad spectrum against fungal pathogens.
Fused nitrogen heterocyclesnamely, pyrazolo[3,4-d]pyridazin-7(6H)-ones have been obtained by exploiting the 1,3-dipolar nature of N-arylsydnones, from hydrazones 3-aryl-4-acetylsydnones via Vilsmeier-Haack strategy. Facile intramolecular nucleophilic addition followed CO2 elimination under reflux or upon microwave irradiation was presented. Plausible mechanisms for formation title compounds are proffered. Structure confirmatory evidence came single-crystal X-ray crystallography.
3‐Arylsydnones are reported to possess striking pharmaceutical potency. α‐Aminoketone, a biologically active structural unit, is built at the fourth (electrophilic) position of sydnone and further derivatized with secondary amine tetrazoles. The α‐aminoketone derivatives sydnones coupled amines 4a – n were docked on enoyl acyl carrier protein (ACP) reductase from Mycobacterium tuberculosis , which revealed that compounds 4b 4f 4i showed efficient C score values different binding modes...
Abstract Improvement of antifungal agents is a good solution to beat the drug‐resistance problems. In this context, series novel bis‐1,2,4‐triazolin‐3‐ones ( 5i‐t ) were designed and synthesized by microwave irradiation (MWI), convenient efficient method. An effort was also made get these one‐pot three‐component reaction (3CR) using 3 ‐ aryl 5 methyl 1,3,4 oxadiazol 2( 3H one 2a b ), formamide dibromo reagent 4c‐h under (MWI). vitro activity carried out against six pathogenic fungi. From...
Abstract Novel biphenyl compounds bearing triazolones have been designed and synthesized with an aim to explore the paramount set of molecules as antihypertensive agents. Our efforts directed towards synthesis Triazolyl‐biphenyl containing different groups at ortho position ring. In particular, cyano, tetrazole oxadiazole substituents ring were structures all these previously unknown 16 confirmed by their spectral characterizations. Binding modes for evaluated docking in a theoretical Human...
Novel angiotensin converting enzyme (ACE) inhibitors were designed based on the structure of commercially available sartans and synthesized by N-alkylation 5-substituted-1Htetrazole with 4'-(bromomethyl)-biphenyl-2-carbonitrile gave 1,5-and 2,5-regioisomers tetrazole.The nitrile group appended to biphenyl nucleus was converted into tetrazole later ring transformed 1,3,4-oxadiazole.The compounds screened for ACE inhibition some exhibited significant results.