A5027695135- Synthesis and biological activity
- Computational Drug Discovery Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Evaluation
- Tuberculosis Research and Epidemiology
- Chemical Synthesis and Analysis
- Crystallography and molecular interactions
- Quinazolinone synthesis and applications
- Cancer therapeutics and mechanisms
- Microbial Natural Products and Biosynthesis
- Phenothiazines and Benzothiazines Synthesis and Activities
- HIV/AIDS drug development and treatment
- Antimicrobial agents and applications
- Synthesis of Organic Compounds
- Diverse Scientific Research Studies
- Crystal structures of chemical compounds
- Synthesis of Tetrazole Derivatives
- Natural Antidiabetic Agents Studies
- Synthesis of β-Lactam Compounds
- Metal complexes synthesis and properties
- Drug Transport and Resistance Mechanisms
JSS Academy of Higher Education and Research
2019-2025
Sarojini Naidu Medical College
2024
Sri Dharmasthala Manjunatheshwara College of Dental Sciences & Hospital
2017-2018
Hindu College of Pharmacy
2017
Karnatak University
2016
Indian Institute of Technology Dharwad
2016
Panjab University
1997-2010
National Council for Cement and Building Materials
2010
Indian Institute of Technology Kanpur
2003
University of Lucknow
1994
Biomolecular interaction of hydralazine with human serum albumin (HSA) was studied by fluorescence, ultravoilet, three-dimensional, synchronous, Fourier transform infrared, lifetime resonance Rayleigh scattering, circular dichroism, and molecular docking techniques. The intrinsic fluorescence HSA quenched a static quenching mechanism. effect β-cyclodextrin on binding studied. Binding constants number sites were evaluated using the Stern–Volmer equation. Thermodynamic parameters (ΔH°, ΔG°,...
Objective: This study investigates the therapeutic potential of Colony Stimulating Factor 1 Receptor (CSF1R) inhibitors in targeting neuroinflammation, focusing on modulation JNK/NLRP3/IL-1β signaling pathway, a key axis contributing to neurodegenerative and neuropsychiatric diseases. Methods: In silico docking analyses were conducted evaluate interactions between CSF1R pivotal inflammatory proteins (JNK, NLRP3, IL-1β). Molecular Dynamics (MD) simulations assessed stability conformational...
Abstract New coumarin‐benzimidazole hybrids ( 3a–f ) have been synthesized from 4‐formylcoumarins and a series of N ‐sulphonation 4 ‐ f) ‐methylation 5 f compounds were obtained ). All the exhibited good antimicrobial activity. Docking studies provide valuable insights to potential binding modes inhibitors. Anti cancer activity compound c shown excellent against HeLa cell line. Whereas d higher HT 29 lines. We calculated LC 50 , TGI GI which show < 10 mg/mL. The characterized by IR, NMR,...
Interactions between the BSA and CAP in docked model. Figure showing H-bonding interactions carisoprodol surrounded by hydrophobic amino acids Leu249, Leu250 Gly247 subdomain IIA.
The well-known CO···X interactions control the crystal packing of o-haloaromatic carboxaldehydes as revealed by X-ray structures a set aldehydes 2−8. intramolecular C−H···X interaction causes to manifest in readily recognizable pattern association, i.e., synthon 1. robustness 1 is amply suggested from isostructurality exhibited dichloro- and dibromo-dialdehydes 3,6 4,7. Further, it found that aldehyde 2, which can exploit CO···Br two distinct ways crystallizes modifications.
Abstract A new series quinoline‐2 H ‐1,2,4‐triazol‐3(4 )‐ones 7 g‐n and 11 were designed synthesized. Docking studies of title compounds with DNA (PDB: 1AU5) long‐chain enoyl‐acyl carrier protein reductase (InhA) enzyme (PDB ID: 4TZK) as anticancer antitubercular targets showed good insights on the possible interactions. Further, tested for in vitro activity against HeLa human cervix tumor cell line also M. tuberculosis H37Rv [MTB] (ATCC‐27294). Some exhibited promising activities both...