A5101419869- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
- Photonic and Optical Devices
- Semiconductor Lasers and Optical Devices
- Photonic Crystals and Applications
- Biosensors and Analytical Detection
- Atherosclerosis and Cardiovascular Diseases
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Electrowetting and Microfluidic Technologies
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Advanced Fiber Laser Technologies
- Strong Light-Matter Interactions
- Head and Neck Surgical Oncology
- Advanced biosensing and bioanalysis techniques
- Advanced Biosensing Techniques and Applications
National University of Singapore
2020-2024
Singapore-MIT Alliance for Research and Technology
2024
Changchun University of Science and Technology
2015
State Key Laboratory on Integrated Optoelectronics
2015
Chinese Academy of Sciences
2015
Institute of Semiconductors
2015
Quantitative nucleic acid amplification tests are of great importance for diagnostics, but current approaches require complex and costly optical setups that limit their nonlaboratory applications. Herein we describe the implementation a microfluidics platform can perform binary DNA-amplification-activated droplet sorting. The digital sort-enabled counting (DISCO) enables label-free absolute quantification acid. This is achieved by provoking pH change in droplets through loop-mediated...
Enzymatic secretion of immune cells (leukocytes) plays a dominant role in host responses to myriad biological triggers, including infections, cancers, and cardiovascular diseases. Current tools probe these leukocytes inadequately profile vital biomarkers; the need for sample preprocessing steps cell lysis, labeling, washing, pipetting inevitably triggers cells, changes its basal state, dilutes individual bulk assays. Using fully integrated system multiplexed profiling native single-cell...
Cytokines, crucial in immune modulation, impact disease progression when their secretion is dysregulated. Existing methods for profiling cytokine suffer from time-consuming and labor-intensive processes often fail to capture the dynamic nature of responses. Here, iSECRETE, an integrated platform that enables synchronous cell activation, wash-free, target-responsive protein detection single-cell IFN-γ analysis within 30 min at room temperature presented. By incorporating a DNA proximity assay...
Square microcavity lasers with a cut-corner are proposed and demonstrated for realizing unidirectional emission single-mode lasers. The mode characteristics of the square resonator investigated by 2-D finite-element method simulation. Far field patterns single petal double petals obtained numerically symmetric antisymmetric modes, respectively. fabricated using planar photolithography inductively coupled-plasma etching techniques. A continuous wave operation side suppression ratio 31 dB is...
The effective manipulation of mode oscillation and competition is fundamental importance for controlling light emission in semiconductor lasers. Here we develop a rate equation model which considers the spatially modulated gain spontaneous emission, are inherently governed by ripple vacuum electromagnetic field Fabry-Pérot (FP) microcavity. By manipulating interplay between spatial external optical injection via dual-beam laser interference, single longitudinal operation observed FP-type...
An AlGaInAs/InP elliptical resonator microlaser laterally confined by a BCB layer, with an output waveguide connected to the minor axis is demonstrated experimentally and investigated numerically. A major of 12μm aspect ratio 1.2 2μm wide fabricated planar techniques. Lasing spectra longitudinal mode wavelength interval 10.6nm, which agreement 2-D finite element method (FEM) simulation results, side suppression ratios (SMSR) 30dB are observed. Numerical results indicate that has better...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): Research Foundation Background Characterizing enzyme secretion with surface antigen expression circulating leukocytes provides deep immunological insights that may benefit diagnostics and therapeutics acute myocardial infarction (AMI). Current methods are limited by laborious sample preparation, lengthy assay time analytical throughput. Purpose We aimed to develop a...