A5085826542- Adipose Tissue and Metabolism
- CAR-T cell therapy research
- Peroxisome Proliferator-Activated Receptors
- Histone Deacetylase Inhibitors Research
- Metabolism, Diabetes, and Cancer
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Cancer Research and Treatments
Xi'an Polytechnic University
2025
Southern Medical University
2023-2024
Henan Cancer Hospital
2024
Zhengzhou University
2024
Nanfang Hospital
2023
Ningbo University
2015
Abstract Background Chimeric antigen receptor (CAR) T cell therapy has shown remarkable responses in hematological malignancies with several approved products, but not solid tumors. Patients suffer from limited response and tumor relapse due to low efficacy of CAR-T cells the complicated immunosuppressive microenvironment. This clinical challenge called for better CAR designs combined strategies improve against changes. Methods In this study, IL-15/IL-15Rα was inserted into extracellular...
To determine the efficacy and safety of selinexor combined with venetoclax (VEN) azactitidine (AZA) for patients relapsed and/or refractory acute myeloid leukemia (R/R AML) . Twelve R/R AML treated plus VEN AZA in Affiliated Cancer Hospital Zhengzhou University from May 2022 to 2023 were included. Their clinical data retrospectively analyzed. Among 12 patients, 5 (41.7%) achieved complete remission (CR) , 1 (8.3%) CR incomplete hematological recovery, partial remission. The median time reach...
Objective: To investigate the risk factors for organoid culture failure in colorectal cancer. Methods: This was a retrospective observational study. Tumor specimens were obtained from 1130 patients with cancer who had undergone surgery or biopsy and no other concurrent malignancies at Nanfang Hospital of Southern Medical University December 2021 to November 2022. Organoid performed on 1231 tumor tissue samples. Univariate analysis multivariate logistic regression used analyze that might have...