A5090872049- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Thermochemical Biomass Conversion Processes
- Advanced Combustion Engine Technologies
- Biodiesel Production and Applications
- Graphene and Nanomaterials Applications
- Graphene research and applications
- Mass Spectrometry Techniques and Applications
- Nanoporous metals and alloys
- Thermal and Kinetic Analysis
- Advanced Drug Delivery Systems
- Coal and Its By-products
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Surface Polishing Techniques
- Nanoparticles: synthesis and applications
- Granular flow and fluidized beds
- Immune Cell Function and Interaction
- Conducting polymers and applications
- Photochromic and Fluorescence Chemistry
- Combustion and flame dynamics
- Electrocatalysts for Energy Conversion
- Laser Material Processing Techniques
- Agricultural Systems and Practices
- Radiopharmaceutical Chemistry and Applications
University of Chinese Academy of Sciences
2020-2025
National Center for Nanoscience and Technology
2020-2025
People's Liberation Army 401 Hospital
2025
Chinese People's Liberation Army
2025
Chinese Academy of Sciences
2012-2024
Ningbo Institute of Industrial Technology
2023-2024
Aero Engine Corporation of China (China)
2024
Beike Biotechnology (China)
2024
University of Science and Technology of China
2020-2023
Peking University
1999-2023
Phototherapy is effective for triggering the immunogenic cell death (ICD) effect. However, its efficacy limited by low 1 O2 generation and photothermal conversion due to two irreconcilable obstacles, namely aggregation-caused-quenching (ACQ) effect photobleaching. In this work, a discretely integrated nanofabrication (DIN) platform (Pt-ICG/PES) developed facile coordination coassembly of cisplatin (Pt), photosensitizer molecules (indocyanine green (ICG)), polymeric spacer (p(MEO2...
Photodynamic therapy (PDT), is a rising star for suppression of in situ and metastatic tumors, yet it impeded by low ROS production off-target phototoxicity. Herein, an aggregation degree editing strategy, inspired gene editing, was accomplished the coordination editor, p(MEO2MA160-co-OEGMA40)-b-pSS30 [POEGS; MEO2MA = 2-(2-methoxyethoxy)ethyl methacrylate, OEGMA oligo(ethylene glycol) methacrylate; pSS poly(styrene sulfonate)] indocyanine green (ICG) to nontoxic Mg2+, forming ICG discretely...
Periodontitis is a chronic inflammatory disease caused by the interaction of oral microorganisms with host immune response. Porphyromonas gingivalis (P.g.) acts as key mediator in subverting homeostasis local system. On one hand, P.g. inhibits phagocytosis and killing capacity cells. other increases selective cytokine release, which beneficial to its further proliferation. Here, we prepared penetrating macrophage-based nanoformulation (MZ@PNM)-encapsulating hydrogel (MZ@PNM@GCP) that...
Carbon-based nanomaterials (CNMs) have recently been found in humans raising a great concern over their adverse roles the hosts. However, our knowledge of vivo behavior and fate CNMs, especially biological processes elicited by gut microbiota, remains poor. Here, we uncovered integration CNMs (single-walled carbon nanotubes graphene oxide) into endogenous flow through degradation fermentation, mediated microbiota mice using isotope tracing gene sequencing. As newly available source for...
Deep brain stimulation technology enables the neural modulation with precise spatial control but requires permanent implantation of conduits. Here, we describe a photothermal wireless deep nanosystem capable eliminating α-synuclein aggregates and restoring degenerated dopamine neurons in substantia nigra to treat Parkinson’s disease. This (ATB NPs) consists gold nanoshell, an antibody against heat-sensitive transient receptor potential vanilloid family member 1 (TRPV1), β-synuclein (β-syn)...
A novel nano-system (PKMCN) with medical value could accumulate in the inflamed colon tissues and exhibit a strong anti-inflammatory effect.
ConspectusThe nano–bio interface refers to the physical between biological system and nanoscale surface topography, functioning as barrier two phases where critical reactions occur. In last decades, advances in nanofabrication techniques have heralded a new research area utilizing precisely engineered surfaces structures control cell cycles, pathways of metabolism, immune responses, so forth. At cellular level, nanomaterials (ENMs) with typical been shown actively affect such stimulating...
The blood circulation is considered the only way for orally administered nanoparticles to enter central nervous systems (CNS), whereas non-blood route-mediated nanoparticle translocation between organs poorly understood. Here, we show that peripheral nerve fibers act as direct conduits silver nanomaterials (Ag NMs) from gut CNS in both mice and rhesus monkeys. After oral gavage, Ag NMs are significantly enriched brain spinal cord of with particle state however do not efficiently blood. Using...
Abstract Background Chimeric antigen receptor (CAR) T cell therapy has shown remarkable responses in hematological malignancies with several approved products, but not solid tumors. Patients suffer from limited response and tumor relapse due to low efficacy of CAR-T cells the complicated immunosuppressive microenvironment. This clinical challenge called for better CAR designs combined strategies improve against changes. Methods In this study, IL-15/IL-15Rα was inserted into extracellular...
A working model of the effect silver nanomaterials on gut microbiota and secretion 5-HT by regulating metabolites.
Purpose The purpose of this paper is to conduct a thorough study the current research status and trends Artificial Intelligence-Generated Content (AIGC), which thriving exerting significant influences on society, economy technology. This will encompass both ample opportunities array emerging risks challenges associated with AIGC. Furthermore, seeks propose practical optimization strategies facilitate its continued development. Design/methodology/approach A total 12,702 documents in Scopus,...
Surfactant-modified graphene hybrids containing azobenzene groups were for the first time prepared, and electrochemical performance was investigated. The obtained by electrostatic interactions between cationic azobenzene-surfactants negatively charged oxide in water. interactions, chemical structure photoresponse of measured using zeta potential values, fluorescence spectra, FTIR, XPS, XRD, SEM, UV-Vis absorption, AFM Raman spectra. estimated cyclic voltammetry. results show that strong...
The biological effect of engineered carbon nanotubes (CNTs) as beneficial biomaterials on the intestine, especially its development, remains unclear. Here, we investigated profitable CNTs with a different graphene layer and surface modification 3D model intestinal organoids demonstrated that (50 μg/mL) promoted development over time (0–5 days). mechanisms involve modulation extracellular matrix (ECM) viscoelasticity intracellular energy metabolism. In particular, reduced hardness through...