A5100733480- Land Use and Ecosystem Services
- Periodontal Regeneration and Treatments
- Geology and Paleoclimatology Research
- Conservation, Biodiversity, and Resource Management
- Radiomics and Machine Learning in Medical Imaging
- Antimicrobial Peptides and Activities
- Dental Trauma and Treatments
- Chemokine receptors and signaling
- Wildlife-Road Interactions and Conservation
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related molecular mechanisms research
- Oral microbiology and periodontitis research
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Inflammatory mediators and NSAID effects
- Remote Sensing in Agriculture
- Bone health and treatments
- Wildlife Ecology and Conservation
- Urban Green Space and Health
- Regulation of Appetite and Obesity
- Karst Systems and Hydrogeology
- Cryospheric studies and observations
- Bone Metabolism and Diseases
Huazhong University of Science and Technology
2023-2024
Union Hospital
2023
University of Chinese Academy of Sciences
2019-2022
Institute of Genetics and Developmental Biology
2021-2022
Research Center for Eco-Environmental Sciences
2019-2021
Chinese Academy of Sciences
2019-2021
Periodontitis is a chronic inflammatory disease caused by the interaction of oral microorganisms with host immune response. Porphyromonas gingivalis (P.g.) acts as key mediator in subverting homeostasis local system. On one hand, P.g. inhibits phagocytosis and killing capacity cells. other increases selective cytokine release, which beneficial to its further proliferation. Here, we prepared penetrating macrophage-based nanoformulation (MZ@PNM)-encapsulating hydrogel (MZ@PNM@GCP) that...
Osteoarthritis (OA) is an inflammatory disease accompanied by synovial joint inflammation, and IL-36 plays important role in this process. Local application of receptor antagonist (IL-36Ra) can effectively control the response, thereby protecting cartilage slowing down development OA. However, its limited fact that it rapidly metabolized locally. We designed prepared a temperature-sensitive poly(lactic-co-glycolic acid)–poly(ethylene glycol)–poly(lactic-co-glycolic acid) (PLGA-PEG-PLGA)...
The karst landform is a typical ecologically vulnerable region, and the problem of rocky desertification in southtern western China has led to impoverishment degraded local ecological environment, which severely limits socioeconomic development. An effective appropriate control requires knowledge about its characteristics variation driving mechanisms. In this study, we chose eight regions as research areas analysed changes ecosystem patterns from 2000 2015. Based on these characteristics,...
Dynamic monitoring of forest ecosystem quality is necessary for restoration program evaluation but remains challenging very large-scale programs. Current methods employ regional indicators that compare the status targeted forests with benchmarks from remnant old-growth communities, however data availability usually limits application available to small scales. We constructed an improved framework, integrating site classification selection and local community delimitation, quantify map using...
Ecological benefits provided by ecosystem assets play an important role in improving human wellbeing. However, there are few feasible methods to combine data on the quantity and quality of describe their state trend. Here, we developed a new remote-sensing-based indicator synthesizing asset for effective assessment at regional or national scale. The includes typological index (TEAI) (e.g., forest index) integrated (IEAI). TEAI IEAI can be used assess trend specific set ecosystems,...
Because of its status as an ecocivilization pilot city, fundamental research on spatial distribution patterns and impact factors the avian community within Xiong'an New Area is necessary for future ecological planning mitigation negative impacts from urbanization. Gradient small cities can provide important information development urbanization gradient communities.A total 30 sample points were selected, communities environmental variables measured a 50 m radius circle. Principal component...
<title>Abstract</title> Synovitis plays a critical role in osteoarthritis (OA), and inhibiting synovitis can significantly alleviate OA symptoms. Denosumab, monoclonal antibody targeting RANKL, inhibits the RANK/NF-κB pathway monocyte–macrophage lineage cells, crucial inflammation. Here, we report novel of denosumab fibroblast-like synoviocytes (FLSs) where it attenuates progression. We first demonstrated that RANKL RANK were highly expressed synovium mice patients. administered systemically...