A5084112727- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Transplantation: Methods and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Renal Diseases and Glomerulopathies
- Cardiac pacing and defibrillation studies
- Aortic aneurysm repair treatments
- Cardiovascular Function and Risk Factors
- Underwater Acoustics Research
- Systemic Lupus Erythematosus Research
- Hemodynamic Monitoring and Therapy
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Organ Transplantation Techniques and Outcomes
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and exercise physiology
- Tracheal and airway disorders
- Marine animal studies overview
- Acute Myocardial Infarction Research
- Chronic Kidney Disease and Diabetes
- Cardiac Ischemia and Reperfusion
- Coronary Interventions and Diagnostics
Corewell Health
2023-2024
Therapeutics Clinical Research
2022-2024
Spectrum Health
2014-2024
Michigan State University
2012-2024
Cleveland Clinic
2024
Corewell Health Blodgett Hospital
2013-2022
Mater Misericordiae University Hospital
2022
Grand Rapids Community College
2021
Johns Hopkins Medicine
2021
Johns Hopkins University
2021
We conducted a prospective study in which 554 patients with chronic bifascicular and trifascicular conduction abnormalities were followed for an average of 42.4 +/- 8.5 months. Heart block occurred 19 patients, 17 successfully treated. The actuarial five-year mortality from event that could conceivably have been bradyarrhythmia was 6 per cent (35 all causes). Of the 160 deaths 67 (42 cent) sudden; most these not ascribable to but tachyarrhythmia myocardial infarction. Mortality higher...
Levosimendan is an inotropic agent that has been shown in small studies to prevent or treat the low cardiac output syndrome after surgery.In a multicenter, randomized, placebo-controlled, phase 3 trial, we evaluated efficacy and safety of levosimendan patients with left ventricular ejection fraction 35% less who were undergoing surgery use cardiopulmonary bypass. Patients randomly assigned receive either intravenous (at dose 0.2 μg per kilogram body weight minute for 1 hour, followed by 0.1...
We studied the effects of afterload reduction in chronic severe aortic insufficiency by measuring hemodynamic response to oral hydralazine 10 consecutive patients. Hemodynamics were also measured during maximal exercise eight these At rest, reduced pulmonary artery wedge pressure from 14 9 mm Hg (p less than 0.01), and increased cardiac index 70% stroke volume 35% (both p 0.001). Before hydralazine, exceeded 20 five patients exercise; with at identical levels exercise, remained below all For...
Sparsentan is a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist (DEARA) examined in the ongoing phase 2 DUET trial for focal segmental glomerulosclerosis (FSGS). In 8-week double-blind period, sparsentan resulted greater proteinuria reduction versus irbesartan. We report long-term efficacy and safety of during open-label extension over more than 4 years.
To determine how arteriolar dilation improves cardiac performance in aortic insufficiency, we evaluated the acute effects of hydralazine 10 patients with chronic severe insufficiency. Control measurements intracardiac and intravascular pressures, output left ventricular volumes were obtained at catheterization. Hydralazine, 0.3 mg/kg i.v. (maximal dose 20 mg), was administered all repeated 30 minutes later. A reduction systemic vascular resistance from 1264 to 710 dyn-sec-cm-5 associated...
A patient underwent mitral valve replacement in 1966 for severe disease. The initial clinical result was excellent but symptoms recurred nine years later, and since 1969 he has had progressive cardiac enlargement. At present is functional class II massive cardiomegaly with gross enlargement of the left atrium, right ventricle, atrium. Cardiac catherisation showed "normal" prosthetic function, on moderate exercise developed atrial pulmonary arterial hypertension. His course illustrates a...
OBJECTIVESThe goal of this study was to compare early postoperative outcomes and actuarial-free survival between patients who underwent repair acute type A aortic dissection during 2000–2005 2006–2010.
Focal segmental glomerulosclerosis (FSGS) is a rare glomerular disease with high unmet clinical need. Interest in proteinuria as surrogate end point for regulatory approval of novel treatments has increased. We assessed the relationship between achieving complete remission (CR) at least once during follow-up and long-term kidney outcomes.This post hoc analysis included all patients enrolled DUET trial sparsentan FSGS open-label extension (OLE). Evaluations occurred every 12 weeks, including...
The goal of this study was to compare early postoperative outcomes and actuarial-free survival between patients who underwent repair acute type A aortic dissection by the method cerebral perfusion used.A total 324 from five academic medical centers January 2000 December 2010. Of those, antegrade (ACP) used for 84 patients, retrograde (RCP) 55 deep hypothermic circulatory arrest (DHCA) 184 during repair. Major morbidity, operative mortality, 5-year actuarial were compared groups. Multivariate...
Double-chamber plethysmography is a well established noninvasive method of assessing airflow obstruction in small lab animals. It allows measurement the specific airway resistance (sRaw), which unlike enhanced pause (Penh), meaningful mechanics parameter. Since sRaw measured spontaneously breathing mice, limitation inability to exclude nasal changes. We recently showed that mice are not truly obligate breathers and after occlusion, nasally can transition an oral mode breathing. now show it...
Gallstone ileus is a rare disease that accounts for 1-4% of intestinal obstructions. Almost exclusively condition in the older female population, it difficult diagnosis to make. We report case gallstone 94-year-old Caucasian female, who presented emergency department with acute-onset nausea, coffee-ground emesis, lack bowel movement, and abdominal distension. On CT scan, was made by presence cholecystoduodenal fistula, pneumobilia, small obstruction. Emergent laparotomy one-stage procedure...
Background: The goal of this study was to compare early postoperative outcomes and actuarial-free survival between patients who underwent repair acute Type A aortic dissection with axillary or femoral artery cannulation. Methods: total 305 from five academic medical centers via (n = 107) 198) cannulation January 2000 December 2010. Major morbidity, operative mortality, 5-year actuarial were compared groups. Multivariate logistic regression used determine predictors Cox hazard ratios...
Long cross clamp times have been associated with poor clinical outcomes, yet some patients require extremely long ischemic to repair complex surgical problems. The purpose of this study was examine short and mid-term survival identify risk factors for mortality morbidity in greater than or equal 300 min.Review our institution's Society Thoracic Surgeons database identified 202 who underwent procedures necessitating aortic min between 2001 2012. Short-term (30-day) outcomes were derived from...
We prospectively evaluated 46 patients who had intrahisian conduction delay. Twenty-three a split His potential and 23 prolonged HV interval with normal QRS complex. In those His, the between two potentials averaged 32.7 msec (range 9--90 msec); in nine this was demonstrated only by atrial pacing. The 20 from group 1:1 atrioventricular have been followed for an average of 18.1 months 2--48 months). All are alive. Three syncope, but Holter monitoring revealed no bradyarrhythmias. narrow...
Abstract Lung transplantation remains an important therapeutic option for idiopathic pulmonary arterial hypertension (IPAH), yet short‐term survival is the poorest among major diagnostic categories. We sought to develop a prediction model 90‐day mortality using United Network Organ Sharing database adults with IPAH transplanted between 2005 and 2021. Variables p value ≤ 0.1 on univariate testing were included in multivariable analysis derive best subset model. The cohort comprised 693...