A5083945495- GDF15 and Related Biomarkers
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Protein Hydrolysis and Bioactive Peptides
- Mercury impact and mitigation studies
- Biochemical effects in animals
- Microfluidic and Capillary Electrophoresis Applications
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular Disease and Adiposity
- Aluminum toxicity and tolerance in plants and animals
- Galectins and Cancer Biology
- Advanced biosensing and bioanalysis techniques
- Advanced Glycation End Products research
- Genomics, phytochemicals, and oxidative stress
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Celiac Disease Research and Management
- Digestive system and related health
Zhengzhou University
2024
Henan Agricultural University
2021-2023
Henan Academy of Agricultural Sciences
2022
Many researchers have found that Pb exposure can cause oxidative stress damage to the body’s tissue. Black soybean peptide (BSP) has a variety of physiological functions, especially in terms stress. Nevertheless, mitigation function BSPs on Pb-induced PC12 cells not been clearly defined. In this study, cell viability was detected by CCK8. Oxidative indicators, such as ROS, GSH/GSSG, MDA, SOD, CAT, GPx, and GR, were tested with biochemical kit. Protein expression Keap1, Nrf2, TXNIP measured...
Lead poisoning causes an oxidative stress response - a key "bridge" connecting various pathways in the human body. Oxidative usually implies imbalance between pro-oxidants and antioxidants. Moreover, Nrf2, Keap1, TXNIP proteins play essential role stress. Some studies showed that pea peptides could alleviate response. However, effect mechanism of peptide on induced by lead PC12 cells has not been reported. Investigating alleviating damage lead. In this study, cell viability was measured CCK8...
It is well known that lead-induced neurotoxicity closely related to oxidative stress. According previous reports, wheat germ peptides (WGPs) isolated from have been shown potent antioxidant capacity. This study hypothesized WGPs could protect PC12 cells Here, the protecting-efficacies of were investigated in pretreated with (200 μM, 4 h) and exposed lead (10 24 h). The capacity was assessed by cell viability, ROS, MDA, SOD, CAT, GR, GPx, GSH, GSSG. experimental results showed WGP3, WGP8,...
Lead (Pb) has many applications in daily life, but recent years, various problems caused by lead exposure have aroused people's concern. Folic acid is widely found fruits and received more attention for its antioxidant function. However, the role of folic lead-induced kidney injury rats unclear. This study was designed to investigate effects on oxidative stress endoplasmic reticulum exposure. Forty specific pathogen-free male Rattus norvegicus were randomly divided into control, lead,...
Abstract Aims This study aimed to identify the distinct change trajectories of Chinese visceral adiposity index (CVAI) over time and investigate their associations with risk type 2 diabetes mellitus (T2DM). Materials Methods included 52 394 participants from prospective project, Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China‐PAR). The CVAI was calculated using measures age, body mass index, waist circumference, triglycerides high‐density lipoprotein cholesterol....
<title>Abstract</title> It is well known that SLC30A10 and RAGE play a crucial role in regulating the transport accumulation of Aβ plaques. Our previous studies have shown early exposure to lead can cause cerebral damage pups due deposition amyloid However, effect on protein expression levels remains unclear. This study aimed verify maternal lead-containing drinking water during pregnancy would affect proteins mice offspring, further verifying lead-induced neurotoxicity. Four groups were...
Background: It is well known that SLC30A10 and RAGE play a crucial role in regulating the transport accumulation of Aβ plaques. Previous studies have shown early exposure to lead can cause cerebral damage pups due deposition amyloid However, effect on protein expression levels remains unclear. This study aimed verify maternal lead-containing drinking water during pregnancy would affect proteins mice offspring, further verifying lead-induced neurotoxicity.Methods: Four groups were exposed 0...
Abstract A recombinant anti-enrofloxacin single-chain antibody (scFv) was produced for the detection of enrofloxacin. An immunized mouse phage display scFv library with a capacity 2.35×10 9 CFU/mL constructed and used screening. After four rounds bio-panning, 10 positives were isolated identified successfully. The highest positive expressed in E. coli BL21. Then, its recognition mechanisms studied using molecular docking method. result showed amino acid residues Leu121 key binding ScFv to...