A5086546388- Nitric Oxide and Endothelin Effects
- Birth, Development, and Health
- Ion channel regulation and function
- Neuroscience of respiration and sleep
- Pregnancy and preeclampsia studies
- Thyroid Disorders and Treatments
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Cardiac electrophysiology and arrhythmias
- Renin-Angiotensin System Studies
- Pulmonary Hypertension Research and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neonatal Respiratory Health Research
- Receptor Mechanisms and Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neurobiology and Insect Physiology Research
- Neonatal and fetal brain pathology
- Ion Transport and Channel Regulation
- High Altitude and Hypoxia
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Function and Risk Factors
- Bat Biology and Ecology Studies
- Cardiovascular Health and Disease Prevention
- Genetics and Physical Performance
Lomonosov Moscow State University
2016-2025
Moscow State University
2023-2024
University Medical Centre Mannheim
2018-2020
Heidelberg University
2018-2020
University Hospital Heidelberg
2018-2020
State Research Center of the Russian Federation
2018
Russian Academy of Sciences
2018
Institute of Biomedical Problems
2016-2018
Maturation represents a process characterized by adaptive changes, particularly in the circulatory system. However, it is not known whether, neonates, potassium channels contribute to NO-induced vasorelaxation at all and, if so, which these are. Therefore, this study tested hypothesis that mediate newborn rats. Young (10- 15-day-old) and adult (2- 3-month-old) male rats were studied using real-time PCR, isometric myography, sharp microelectrode technique on saphenous arteries. We observed...
Aim Calcium-activated potassium channels of high conductance (BK Ca channels) are important contributors to vascular smooth muscle membrane potential and thus tone. BK can promote vasodilation by facilitating vessel responses NO. may also serve as limiters the anticontractile effect However, it is unclear whether act simultaneously facilitators in different regions. Therefore, this study tested hypothesis that both facilitate limit NO-induced vasorelaxation multiple vessels. Methods...
Acidosis often occurs during clinical complications in newborns and can lead to changes the mechanisms of arterial tone regulation. However, it is unknown how acidosis affects activity Ca2+-activated chloride channels (CaCC) arteries early ontogenesis. We hypothesized that their may increase acidosis. studied isometric contractions saphenous isolated from adult 10-13-day-old rats. Intracellular pH was measured using a fluorescent indicator BCECF-AM simultaneously with recording contractile...
Abstract Aim Potassium channels are key regulators of smooth muscle membrane potential and arterial tone. However, the roles potassium in vascular tone regulation systemic circulation during early postnatal development poorly understood. Therefore, this study tested hypothesis that negative feedback vasocontraction by changes maturation. Methods Experiments were performed on endothelium‐denuded saphenous arteries from 10‐ to 15‐day‐old 2‐ 3‐month‐old male rats. Isometric force recorded using...
The vasomotor role of K2P potassium channels during early postnatal development has never been investigated. We tested the hypothesis that TASK-1 channel (K2P family member) contribution to arterial vascular tone and BP is higher in period than adulthood.We studied 10- 15-day-old ("young") 2- 3-month-old ("adult") male rats performing digital PCR (dPCR) (using endothelium-intact saphenous arteries), isometric myography, sharp microelectrode technique, quantitative (qPCR) Western blotting...
The mechanisms of vascular alterations resulting from early thyroid hormones deficiency are poorly understood. We tested the hypothesis that antenatal/early postnatal hypothyroidism would alter activity endothelial NO pathway and Rho-kinase pathway, which specific for developing vasculature. Dams were treated with propylthiouracil (PTU, 7 ppm) in drinking water during gestation 2 weeks after delivery, their progeny had normal body weight but markedly reduced blood levels (ELISA). Small...
Aim: TASK-1 channels are established regulators of pulmonary artery tone but their contribution to the regulation vascular in systemic arteries is poorly understood. We tested hypothesis that channel functional impact differs among beds, this associated with differences expression and may increase alkalization extracellular environment. Therefore, we evaluated level vasomotor role mesenteric renal arteries. Methods: Pulmonary, from male Wistar rats were used for mRNA (qPCR) protein content...
Introduction: Functional tests and training regimens intensity-controlled by an individual are used in sport practice, clinical rehabilitation, space medicine. The model of voluntary wheel running rats can be to explore molecular mechanisms such humans. Respiratory locomotor muscles demonstrate diverse adaptations treadmill exercise, but the effects exercise on these muscle types have not been compared yet. Therefore, this work aimed at ET rat triceps brachii diaphragm with special attention...
Abstract Membrane transporters and their functional contribution in vasculature change during early postnatal development. Here we tested the hypothesis that of Cl − channels to arterial contraction declines development this decline is associated with trophic sympathetic influence. Endothelium‐denuded saphenous arteries from 1- 2-week-old 2- 3-month-old male rats were used. Arterial was assessed isometric myograph, some experiments combined measurements membrane potential. mRNA protein...
Nitric oxide (NO) deficiency during pregnancy is a key reason for preeclampsia development. Besides its important vasomotor role, NO shown to regulate the cell transcriptome. However, role of in transcriptional regulation developing smooth muscle has never been studied before. We hypothesized that early ontogeny, arterial muscle-specific genes expression. Pregnant rats consumed NO-synthase inhibitor L-NAME (500 mg/L drinking water) from gestational day 10 till delivery, which led an increase...
Abstract Intrauterine growth restriction (IUGR) is one of the most common pathologies pregnancy. The cardiovascular consequences IUGR do not disappear in adulthood and can manifest themselves pathological alterations vasomotor control. hypothesis was tested that weakens anticontractile influence NO augments procontractile Rho-kinase arteries adult offspring. To model rat, dams were 50% food restricted starting from gestational day 11 till delivery. Mesenteric coronary male offspring studied...
The developmental changes of the caval (SVC) and pulmonary vein (PV) myocardium electrophysiology are traced throughout postnatal ontogenesis. in SVC as well PV demonstrate age-dependent differences ability to maintain resting membrane potential, manifest automaticity a form ectopic action potentials basal condition responses adrenergic stimulation. Electrophysiological characteristics two distinct types thoracic change an opposite manner during early ontogenesis with increased...