Hanlu Wang

ORCID: 0000-0001-8867-4963
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About
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Research Areas
  • Catalysis and Hydrodesulfurization Studies
  • Catalytic Processes in Materials Science
  • Free Radicals and Antioxidants
  • Chemical Synthesis and Reactions
  • Metal complexes synthesis and properties
  • Polyoxometalates: Synthesis and Applications
  • Metal-Organic Frameworks: Synthesis and Applications
  • Advanced biosensing and bioanalysis techniques
  • RNA and protein synthesis mechanisms
  • Nanomaterials for catalytic reactions
  • Computational Drug Discovery Methods
  • Conducting polymers and applications
  • Covalent Organic Framework Applications
  • RNA Interference and Gene Delivery
  • Photochemistry and Electron Transfer Studies
  • Organic Light-Emitting Diodes Research
  • Polymer crystallization and properties
  • Thermal and Kinetic Analysis
  • Advanced Photocatalysis Techniques
  • SARS-CoV-2 and COVID-19 Research
  • Monoclonal and Polyclonal Antibodies Research
  • Hydraulic and Pneumatic Systems
  • MXene and MAX Phase Materials
  • Oil and Gas Production Techniques
  • Ionic liquids properties and applications

Guangdong University of Petrochemical Technology
2014-2024

Shanghai Cell Therapy Research Institute
2024

Ningbo University
2024

Second People’s Hospital of Huai’an
2022-2024

Xuzhou Medical College
2022-2024

Fujian Medical University
2020-2023

Fujian Provincial Hospital
2021-2023

University of Jinan
2019-2023

Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2022

Peking Union Medical College Hospital
2022

Abstract Design of single‐site catalysts with catalytic sites at atomic‐scale and high atom utilization, provides new opportunities to gain superior performance for targeted reactions. In this contribution, we report a one‐pot green approach in situ implanting single tungsten (up 12.7 wt.%) onto the nodes defective UiO‐66(Zr) structure via forming Zr‐O‐W bonds under solvent‐free condition. The displayed extraordinary activity oxidative removal sulfur compounds (1000 ppm S) room temperature...

10.1002/anie.202107018 article EN Angewandte Chemie International Edition 2021-06-14

Creation of rich open metal sites (defect) on the nodes metal-organic frameworks (MOFs) is an efficient approach to enhance their catalytic performance in heterogeneous reactions; however, direct generation such defects remains challenging. In this contribution, we developed situ green route for rapid fabrication defective MOF-808(Zr) with Zr-OH/OH2 (occupying 25% Zr coordination sites) and hierarchical porosity without assistance formic acid solvent. The optimal not only displayed superior...

10.1021/acs.inorgchem.2c04364 article EN Inorganic Chemistry 2023-03-01

Abstract Host–guest catalyst provides new opportunities for targeted applications and the development of strategies preparing host–guest catalysts is highly desired. Herein, an in situ solvent‐free approach developed implanting ZrW 2 O 7 (OH) (H O) nanorods (ZrW‐NR) nitro‐functionalized UiO‐66(Zr) (UiO‐66(Zr)‐NO ) with hierarchical porosity, encapsulation ZrW‐NR enables as‐prepared remarkably enhanced catalytic performance both oxidative desulfurization (ODS) acetalization reactions....

10.1002/smll.202311249 article EN Small 2024-03-14

Aptamers are widely used in numerous biochemical, bioanalytical, and biological studies. Most aptamers developed through an vitro selection process called SELEX against either purified targets or living cells expressing of interest. We report here vivo mice using a PEGylated RNA library for the identification 2′-F aptamer (RA16) that specifically binds to NCI-H460 non-small-cell lung cancer with affinity (KD) 9 ± 2 nM. Interestingly, RA16 potently inhibited cell proliferation dose-dependent...

10.1016/j.omtn.2017.12.003 article EN cc-by-nc-nd Molecular Therapy — Nucleic Acids 2017-12-09

Antithrombin (AT) is the main physiological anticoagulant involved in hemostasis. Hereditary AT deficiency a rare autosomal dominant thrombotic disease mainly caused by mutations SERPINC1, which was usually manifested as venous thrombosis and pulmonary embolism. In this study, we analyzed clinical characteristics screened for mutant genes two pedigrees with hereditary deficiency, functional effects of pathogenic were evaluated.Candidate gene variants next-generation sequencing to screen...

10.1186/s12959-022-00443-6 article EN cc-by Thrombosis Journal 2023-01-09

Systemic lupus erythematosus is an autoimmune disease that involves multiple organ systems. One of its major complications, nephritis (LN), associated with a high mortality rate, and children-onset LN have more severe course worse prognosis than adults. Oxidative stress inflammatory responses are involved in development pathogenesis. Thus, this study aimed to explore the role signaling regulation Nrf2/HMGB1/TLR/NF-κB pathway pathogenesis unravel expression TLR4+CXCR4+ plasma cells subset...

10.1186/s12969-023-00909-5 article EN cc-by Pediatric Rheumatology 2023-10-23

Cu(<sc>ii</sc>) ion with <bold>L</bold> led to a rapid and sensitive color change from colorless yellow.

10.1039/d0ra09910d article EN cc-by RSC Advances 2021-01-01

A surprisingly low pKa (4.3) for a Cu(II) bridging water was found in the presented complex, Cu22L, resulting 3 orders of magnitude higher phosphodiesterase activity on BNPP than Zn22L at typical lysosomal pH (∼5.0).

10.1039/c1cc12466h article EN Chemical Communications 2011-01-01

The novel dinuclear Zn(II) complex (1) containing a β-CD dimer could accelerate BNPP (a DNA substitute) hydrolysis more efficiently than catalyze HPNP RNA transesterification with different mechanisms involved; the β-CDs played remarkably roles.

10.1039/c0cc00838a article EN Chemical Communications 2010-01-01
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