A5055388587- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- DNA and Nucleic Acid Chemistry
- Environmental Justice and Health Disparities
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Wastewater Treatment and Reuse
- Heavy metals in environment
- Viral Infections and Immunology Research
- Protein Degradation and Inhibitors
- Heavy Metal Exposure and Toxicity
Scripps Research Institute
2023-2025
Scripps (United States)
2025
The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology
2023
University of Notre Dame
2018-2020
Abstract Target validation and identification of binding sites are keys to the development bioactive small molecules that target RNA. Herein, we describe optimized protocols profile molecule–RNA interactions define in RNAs using covalent chemistry. Various reactive modules appended an RNA-binding molecule were studied for cross-linking RNA target. Electrophilic modules, whether N-chloroethyl aniline or diazirine, have profiles consistent with induced proximity; however, probes more specific...
Background and Hypothesis: Lead (Pb) was phased out of paint gasoline over 40 years ago due to neurotoxicity in humans, but has persisted soils poses a legacy threat many. The Indianapolis 46218 zip code had >10% children exhibiting Pb poisoning. This historically high soil levels, is undergoing redevelopment. We hypothesize that redevelopment will act re-expose new populations people the present area. Experimental Design or Project Methods: sampled 5 parks 7 playgrounds. Stratified...