A5038271815- Alzheimer's disease research and treatments
- Ginkgo biloba and Cashew Applications
- Parkinson's Disease Mechanisms and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Lipoproteins and Cardiovascular Health
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Lipid metabolism and disorders
Scripps (United States)
2025
Scripps Research Institute
2025
Imperial College London
2023
University of Eastern Finland
2003-2012
Kuopio University Hospital
2012
The metabolic syndrome (MetS) is defined as a clustering of cardiovascular risk factors characterized by insulin resistance. We investigated the relationship MetS and its single components, all six different criteria, with coronary heart disease (CHD), (CVD), all-cause mortality in prospective population-based study.The was according to World Health Organization (WHO), European Group for Study Insulin Resistance (EGIR), National Cholesterol Education Program (NCEP), American College...
Abstract. Wang J, Stančáková A, Soininen P, Kangas AJ, Paananen Kuusisto Ala‐Korpela M, Laakso M (University of Eastern Finland and Kuopio University Hospital, Kuopio; Institute Clinical Medicine, Oulu, Oulu; Finland, Research Center, Finland). Lipoprotein subclass profiles in individuals with varying degrees glucose tolerance: a population‐based study 9399 Finnish men. J Intern Med 2012; doi: 10.1111/j.1365‐2796.2012.02562.x. Objectives. We investigated serum concentrations lipoprotein...
Abstract Target validation and identification of binding sites are keys to the development bioactive small molecules that target RNA. Herein, we describe optimized protocols profile molecule–RNA interactions define in RNAs using covalent chemistry. Various reactive modules appended an RNA-binding molecule were studied for cross-linking RNA target. Electrophilic modules, whether N-chloroethyl aniline or diazirine, have profiles consistent with induced proximity; however, probes more specific...
An increasing number of cases where amyloids different proteins are found in the same patient being reported. This observation complicates diagnosis and clinical intervention. Amyloids amyloid-β peptide or protein α-synuclein traditionally considered hallmarks Alzheimer's Parkinson's diseases, respectively. However, co-occurrence these has also been reported patients diagnosed with either disease. Here, we show that soluble species containing can induce aggregation α-synuclein. Fibrils...
ABSTRACT An increasing number of cases where amyloids different proteins are found in the same patient being reported. This observation complicates diagnosis and clinical intervention. Amyloids amyloid-β peptide or protein α-synuclein traditionally considered hallmarks Alzheimer’s Parkinson’s diseases, respectively. However, co-occurrence these has also been reported patients diagnosed with either disease. Here, we show that soluble species containing can induce aggregation α-synuclein....