A5102772198- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Connective tissue disorders research
- BRCA gene mutations in cancer
- Neuropeptides and Animal Physiology
- Dermatological and Skeletal Disorders
- Acute Myeloid Leukemia Research
- Genetic factors in colorectal cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Vascular Procedures and Complications
- Prostate Cancer Treatment and Research
- Plant Pathogens and Resistance
- Chronic Myeloid Leukemia Treatments
- Birth, Development, and Health
- PI3K/AKT/mTOR signaling in cancer
- Menopause: Health Impacts and Treatments
- Heart Rate Variability and Autonomic Control
- Wnt/β-catenin signaling in development and cancer
- Drug Transport and Resistance Mechanisms
- Cardiovascular and exercise physiology
- Glutathione Transferases and Polymorphisms
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Blood Pressure and Hypertension Studies
- Colorectal Cancer Screening and Detection
Nicolaus Copernicus University
2011-2023
Collegium Medicum in Bydgoszcz
2015-2023
University of British Columbia
2020-2023
Kelowna General Hospital
2022-2023
Catharina Ziekenhuis
2016
Radboud University Nijmegen
2016
Bureau Waardenburg (Netherlands)
2005
Utrecht University
2005
University Medical Center Utrecht
2000-2002
Schools of Visual Arts, The Royal Danish Academy of Fine Arts
1998-1999
Randomized trials have shown an initial survival benefit of endovascular over conventional open abdominal aortic aneurysm repair but no long-term difference up to 6 years after repair. Longer follow-up may be required demonstrate the cumulative negative impact on higher reintervention rates associated with repair.We updated results Dutch Endovascular Aneurysm Management (DREAM) trial, a multicenter, randomized controlled trial comparing repair, 15 follow-up. Survival and reinterventions were...
<h3>Abstract</h3> <b>Objective</b> : To examine the effect of a reduced sodium and increased potassium magnesium intake on blood pressure. <b>Design</b> Randomised double blind placebo controlled trial. <b>Setting</b> General population suburb Rotterdam. <b>Subjects</b> 100 men women between 55 75 years age with untreated mild to moderate hypertension. <b>Interventions</b> During 24 weeks intervention group received mineral salt (sodium: potassium: 8:6:1) foods prepared salt. Controls common...
Long-term survival is similar after open or endovascular repair of abdominal aortic aneurysm. Few data exist on the effect either procedure long-term health-related quality life (HRQoL) and health status.Patients enrolled in a multicentre randomized clinical trial (DREAM trial; 2000-2003) Europe versus (EVAR) aneurysm were asked to complete questionnaires status HRQoL. HRQoL scores assessed at baseline 13 time points thereafter, using generic tools, Medical Outcomes Study 36-Item Short-Form...
Collagen, the most abundant human protein, is a significant component of extracellular matrix (ECM) in tissues and organs like skin, bone, ligaments, tendons. Collagen secretion complex, multistage process involving many molecules. A protein playing one main functions this TANGO1 encoded by MIA3 gene. In hypermobile type Ehlers-Danlos syndrome (hEDS), common collagenopathies with no known genetic background, disrupted molecules (including collagen) was observed.The aim study evaluation gene...
Germline mutations of the CHEK2 gene have been reported in some myeloid and lymphoid malignancies, but their impact on development essential thrombocythemia has not studied. In 16 out 106 (15.1%) consecutive patients, newly diagnosed with thrombocythemia, we found one four analyzed mutations: I157T, 1100delC, IVS2+1G>A or del5395. They were associated increased risk disease (OR=3.8; P=0.002). The median age at ET diagnosis among CHEK2+/JAK2V617F+ patients was seven years lower than that...
Germline mutations of the CHEK2 gene have been reported to be associated with breast cancer. In this study, we analyzed association risk development cancer in women North-Central Poland.420 and 435 controls were tested for three protein truncating (IVS2 + 1G > A, 1100delC, del5395) one missense (I157T) mutation. IVS2 A I157T identified by RFLP-PCR, 1100delC variant was using an ASO-PCR del5395 mutation multiplex-PCR. The statistical tests: odds ratio (OR) Fisher's exact test used.In 33 out...
Abstract: In an earlier study using Caco‐2 cells, in vitro cell culture model of the intestinal mucosa, we have shown that acyloxyalkoxy‐based cyclic prodrugs 3 and 4 opioid peptides [Leu 5 ]‐enkephalin( 1 , H‐Tyr‐GLY‐Gly‐Phe‐Leu‐OH) DADLE( 2 H‐Tyr‐ d ‐Ala‐Gly‐Phe‐ ‐Leu‐OH), respectively, were substrates for apically polarized efflux systems therefore less able to permeate monolayers than themselves. attempt explain how structure may influence recognition these as by systems, determined...
Abstract: The objective of this work was to synthesize the cyclic prodrugs 1 and 2 [Leu 5 ]‐enkephalin (Tyr‐Gly‐Gly‐Phe‐Leu‐OH) DADLE (Tyr‐D‐Ala‐Gly‐Phe‐D‐Leu‐OH), respectively, using an (acyloxy)alkoxy linker. were synthesized via a convergent method promoiety that connected C ‐ N ‐terminus peptides. key intermediates compounds 6a 9a for prodrug 6b 9b . (or ) coupled give compound 10a 10b ). protecting groups removed from 11a 11b, which then treated with HBTU in 40% 53% yields,...
The Ehlers-Danlos syndrome (EDS) is a non-inflammatory, heritable connective tissue disorder divided into 13 types according to the 2017 International Classification of syndromes. One subtypes EDS, classical (cEDS), characterized by joint hypermobility, skin hyperextensibility and atrophic scars, which are major criteria cEDS.In this study, first in Central Eastern Europe, 44 patients were investigated. All them tested for COL5A1 mutations with direct DNA sequencing.The study group included...
The detection of antinuclear autoantibody (ANA) is dependent on many factors and varies between the populations. aim study was first to assess prevalence ANA in Polish adult population depending age, sex cutoff threshold used for results obtained. Second, we estimated occurrence individual types ANA-staining patterns. We tested 1731 patient samples using commercially available IIFA two thresholds 1:100 1:160. found 260 participants (15.0%), but percentage positive strongly depended level....
We tested the association between HOXB13 G84E (rs138213197) germline mutation and PC risk in Polish men. DNA from 103 consecutive, newly diagnosed patients hospitalised because of men: volunteers, healthy at time study. The was genotyped using Sanger sequencing. detected 2.9% men (3/103) not any man. Two carriers originated two 25 families fulfilling hereditary prostate cancer criteria (HPC) one carrier family among 78 without HPC (PC frequency: 8% vs. 1.3%, OR = 6.70, p 0.13). In three...
The frameshift NOD2 gene mutation 3020insC is predominantly associated with Crohn's disease, but predisposes to many types of common cancers as well. We studied the frequency this mutant allele in 148 breast cancer women from Bydgoszcz region Poland. was present 8.8% patients. mean age at diagnosis carriers 43 years. did not find any patients diagnosed after 50 There no association a strong family history cancer. On contrary, (11.4%) two times higher families single case and aggregation...
A small but important proportion of patients (4-10 %) with AML have germline mutations. They can cause the development at an earlier age, confer a higher risk relapse or predispose to secondary leukemias, including therapy-related leukemias. The analysis mutations in patient and his/her family is also critical for selection suitable donors if candidate hematopoietic stem cell transplantation (HSCT). 103 unrelated consecutive de novo were enrolled study. Control group consisted persons from...