A5086378445- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Vascular Procedures and Complications
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Infectious Aortic and Vascular Conditions
- Connective tissue disorders research
- Renal and Vascular Pathologies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Advanced X-ray and CT Imaging
- Acute Kidney Injury Research
- Cerebrovascular and Carotid Artery Diseases
- Photoacoustic and Ultrasonic Imaging
- Acute Ischemic Stroke Management
- Ultrasound and Hyperthermia Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Medical Image Segmentation Techniques
- Bone health and treatments
- COVID-19 and healthcare impacts
- Delphi Technique in Research
- Hemodynamic Monitoring and Therapy
- Diagnosis and Treatment of Venous Diseases
- Cardiovascular Health and Disease Prevention
University of Amsterdam
2021-2025
Amsterdam University Medical Centers
2018-2025
Vrije Universiteit Amsterdam
2008-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2011-2024
Amsterdam UMC Location University of Amsterdam
2007-2024
University of Oxford
2023-2024
St Mark's Hospital
2024
Amsterdam Neuroscience
2020-2022
Maasstad Ziekenhuis
2022
Dutch Institute for Clinical Auditing
2020-2021
The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines the care of patients with aneurysms abdominal aorta and iliac arteries in succession to 2011 2019 versions, aim assisting physicians selecting best management strategy.
Randomized trials have shown an initial survival benefit of endovascular over conventional open abdominal aortic aneurysm repair but no long-term difference up to 6 years after repair. Longer follow-up may be required demonstrate the cumulative negative impact on higher reintervention rates associated with repair.We updated results Dutch Endovascular Aneurysm Management (DREAM) trial, a multicenter, randomized controlled trial comparing repair, 15 follow-up. Survival and reinterventions were...
Abstract Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating research to improve diagnostics, discover test novel preventive curative therapies, all which warrant experimental models that recapitulate human disease. The translation basic science results clinical practice is challenging task, in particular for complex conditions such as cardiovascular diseases, often result from multiple risk factors comorbidities. This difficulty might lead some...
To describe outcomes after elective and non-elective fenestrated-branched endovascular aortic repair (FB-EVAR) for thoracoabdominal aneurysms (TAAAs).
Introduction: Abdominal aortic aneurysms (AAAs) and peripheral artery disease (PAD) are two vascular diseases with a significant risk of major adverse cardiovascular events mortality. A challenge in current management is the unpredictable progression individual patients. The VASCUL-AID-RETRO study aims to develop trustworthy multimodal predictive artificial intelligence (AI) models for multiple tasks including stratification patients AAA PAD. Methods: will collect data from 5000 6000 PAD...
Abstract Ruptured abdominal aortic aneurysms (AAA) are associated with overall mortality rates up to 90%. Despite extensive research, mechanisms leading AAA formation and advancement still poorly understood. Smooth muscle cells (SMC) predominant in the medial layer maintain wall structure. Apoptosis of SMC is a well-known phenomenon pathophysiology AAA. However, remaining function less extensively studied. The aim this study assess vitro contractility human non-pathologic SMC. Biopsies were...
Simultaneous analysis of multiple genes using next-generation sequencing (NGS) technology has become widely available. Copy-number variations (CNVs) in disease-associated have emerged as a cause for several hereditary disorders. CNVs are, however, not routinely detected NGS analysis. The aim this study was to assess the diagnostic yield and prevalence our panel Hereditary Thoracic Aortic Disease (H-TAD)-associated genes. Eight hundred ten patients suspected H-TAD were analyzed by targeted 21...
Purpose: To evaluate the midterm outcomes of thoracic endovascular aortic repair (TEVAR) using chimney grafts (ch-TEVAR) or stent-grafts with fenestrations made on back table (f-TEVAR) to treat dissection (TAD) and aneurysm (TAA). Materials Methods: A retrospective analysis was conducted 474 consecutive patients (mean age 62.3±10.7 years; 346 men) treated either f-TEVAR (n=110) ch-TEVAR (n=364) for 352 TADs (81 271 ch-TEVAR) 122 TAAs (29 93 from 2008 2016. The primary endpoints at 30 days...
To determine gutter size and stent-graft geometry in an vitro juxtarenal aneurysm model using various chimney graft (CG) configurations.Two silicone aortic models were constructed combining different diameters of the aorta renal artery. In a single-branched CG configuration, 2 sizes (23 28.5 mm) Excluder stent-grafts tested individually with types CGs: Advanta balloon-expandable (BE) (6×59 12×61 Viabahn self-expanding (SE) (6×50 13×50 mm). All combinations short (10-mm) long (20-mm) sealing...
ObjectiveThe midterm outcomes of the low profile Zenith Alpha Abdominal Endovascular Graft from ZEnith alPHa for aneurYsm Repair (ZEPHYR) registry are reported.MethodsThe ZEPHYR is a physician initiated, multicentre, non-randomised, core laboratory controlled, prospective registry. Inclusion criteria were patients with non-ruptured abdominal aortic aneurysm maximum diameter ≥ 50 mm or enlargement > 5 within 6 months, site reported infrarenal neck length 10 and intention to electively implant...
We provide insight into the presentation, diagnostics, treatment, and accompanying clinical difficulties complications of an arterio-ureteral fistula add 11 patients with to 90 described in literature.A retrospective search was done for confirmed cases that were treated at 3 medical centers.A total reviewed from 1980 2006. A history major abdominal surgery had essential role 10 cases, especially vascular intervention 8. All presented varying manifestations hematuria. Ureteral contrast...
ObjectivePerivascular adipose tissue (PVAT) contributes to vascular homeostasis and is increasingly linked pathology. PVAT density volume were associated with abdominal aortic aneurysm (AAA) presence dimensions on imaging. However, mechanisms underlying the role of in AAA have not been clarified. This study aimed explore differences from using gene expression functional tests.MethodsHuman control subcutaneous collected during open surgery. Gene analyses tests performed. The group consisted...
Objective To summarize characteristics, complications, and success rates of different catheter-directed thrombolysis (CDT) protocols for the treatment lower extremity deep venous thrombosis (LE-DVT). Methods A systematic review using electronic databases (MEDLINE, Scopus, Web Science) was performed to identify randomized controlled trials observational studies related LE-DVT treated with CDT. random-effects model meta-analysis obtain pooled proportions early postthrombotic syndrome (PTS),...
The antibiotic doxycycline is known to inhibit inflammation and was therefore considered as a therapeutic prevent abdominal aortic aneurysm (AAA) growth. Yet mitochondrial dysfunction key-characteristic of clinical AAA disease. We hypothesize that impairs function in the aorta smooth muscle cells (SMCs). Doxycycline induced mitonuclear imbalance, reduced proliferation diminished expression typical contractile cell (SMC) proteins. To understand underlying mechanism, we studied krüppel-like...