A5085657449- Genetics, Aging, and Longevity in Model Organisms
- Animal Behavior and Reproduction
- Circadian rhythm and melatonin
- Climate Change and Health Impacts
- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Insect Utilization and Effects
- Insect behavior and control techniques
- Isotope Analysis in Ecology
- Physiological and biochemical adaptations
- Insect-Plant Interactions and Control
- Dietary Effects on Health
- Insect Pest Control Strategies
- Invertebrate Immune Response Mechanisms
University of Liverpool
2023
University of Sheffield
2018-2020
The Smurf Assay (SA) was initially developed in the model organism Drosophila melanogaster where a dramatic increase of intestinal permeability has been shown to occur during aging (Rera et al., 2011). We have since validated protocol multiple other organisms (Dambroise 2016) and utilized assay further our understanding (Tricoire Rera, 2015; Rera 2018). SA now also used by labs assess barrier (Clark Katzenberger Barekat 2016; Chakrabarti Gelino 2016). itself is simple; however, numerous...
Dietary restriction (DR) extends life span across taxa. Despite considerable research, universal mechanisms of DR have not been identified, limiting its translational potential. Guided by the conviction that evolved as an adaptive, pro-longevity physiological response to food scarcity, biomedical science has interpreted activator molecular pathways. Current evolutionary theory predicts organisms invest in their soma during DR, and thus when resource availability improves, should outcompete...
The extension of lifespan via the restriction nutrients (dietary restriction) remains a poorly-understood phenomenon both within context life-history theory, and at mechanistic level, despite presenting as an ideal opportunity for targeted interventions. A body evidence has formed, disputing classical model simple, strategic allocation energy towards either reproduction or somatic maintenance; macronutrient, more recently, micronutrient intake (like methionine) been shown to play role in...
The extension of lifespan via the restriction nutrients (dietary restriction) remains a poorly-understood phenomenon both within context life-history theory, and at mechanistic level, despite presenting as an ideal opportunity for targeted interventions. A body evidence has formed, disputing classical model simple, strategic allocation energy towards either reproduction or somatic maintenance; macronutrient, more recently, micronutrient intake (like methionine) been shown to play role in...
The effect of nutrition on life-history has received considerable attention from evolutionary theory and mechanistic studies, particularly in relation to the ability dietary restriction extend lifespan. A body evidence formed, disputing classical model a simple strategic allocation energy towards either reproduction or somatic maintenance; macro- micronutrient intake been shown play role mediating plastic responses fitness components, often obscuring an observable trade-off. For example,...
Dietary restriction (DR) is a key focus in ageing research. Specific conditions and genotypes were recently found to negate lifespan extension by DR, questioning its universal relevance. However, the concept of dietary reaction norms explains why effects DR might be obscured some situations. We tested importance measuring longevity fecundity on five diets genotypes, with without water supplementation female Drosophila melanogaster (N>25,000). substantial genetic variation response diet....
Abstract Dietary restriction (DR) consistently and universally extends health-and lifespan across taxa. Despite efforts to uncover the mechanisms underpinning DR - ultimately translate its beneficial outcomes humans precise universal have not been identified. In biomedical science, effects of are interpreted as regulating pro-longevity molecular pathways. This reasoning is guided by conviction that evolved an adaptive, physiological response restricted food intake. Current evolutionary...
Abstract Agriculture remains a major source of subsistence for local communities in India. However, agricultural yield can be strongly affected by pest outbreaks. This result economic losses small‐scale farmers who already experience socio‐economic challenges, such as lack appropriate infrastructure and subsides. Sophisticated management techniques (e.g. sterile insect technique) are less accessible to small developing countries, therefore, alternative cost‐effective approaches needed. Here,...
Summary Dietary restriction (DR) is a key focus in ageing research. Specific conditions and genotypes were recently found to negate lifespan extension by DR, questioning its universal relevance. However, the conceptual framework of dietary reaction norms explains why DR’s effects might not be apparent some situations. We tested comprehensively importance measuring longevity fecundity on five diets genotypes, with without water supplementation fly (N>25,000). substantial genetic variation...