A5019153298- Bone and Joint Diseases
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Hip disorders and treatments
- Orthopedic Infections and Treatments
- Dermatological and COVID-19 studies
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Hematological disorders and diagnostics
- Lower Extremity Biomechanics and Pathologies
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Myofascial pain diagnosis and treatment
- Shoulder Injury and Treatment
- Healthcare Systems and Reforms
- Tendon Structure and Treatment
- Brucella: diagnosis, epidemiology, treatment
- Acupuncture Treatment Research Studies
- Sports injuries and prevention
- Advanced X-ray and CT Imaging
- Bone health and osteoporosis research
- Cardiac Imaging and Diagnostics
- Bone fractures and treatments
China-Japan Friendship Hospital
2018-2023
Peking University
2019-2023
Peking University Shougang Hospital
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2022
First Affiliated Hospital of Zhengzhou University
2021
Peking Union Medical College Hospital
2021
Glucocorticoids could induce injury and apoptosis of bone microvascular endothelial cells (BMECs) in the femoral head, which is associated with development osteonecrosis osteoporosis. Icariin a prenylated flavonol glycoside isolated from Epimedium brevicornum, serving as main active pharmaceutical constituent to treat loss. Currently, impact autocrine activity extracellular vesicles (EVs) induced by icariin on glucocorticoid-induced BMECs still be confirmed. In this study, EVs were treated...
Abstract Background Despite the innovations in total knee arthroplasty (TKA), there is still a subset of patients who do not acquire significant relief or expected satisfaction after primary TKA. However, this subgroup gains improvements more less terms objective quantified assessments procedure. The purpose our study to explore factors that correlate with patients’ and identify minimal clinically important difference (MCID) minimum change (MIC) clinical parameters. Methods We conducted...
<b><i>Introduction:</i></b> Currently, many clinical experiments are being conducted to study the effect of acupuncture on skeletal muscle contusions, and its therapeutic has been confirmed some extent. However, mechanism recovery by electroacupuncture (EA) in muscles after blunt trauma remains unknown. <b><i>Objective:</i></b> To determine whether EA at Zusanli can contribute regeneration contused molecular involved....
Bone microvascular endothelial cells (BMECs) constitute the central part of femoral head's intramural microenvironment network and have an essential role in development steroid‑induced osteonecrosis head. Recently, rapid microfluidic technology has led to innovations fields chemistry, medicine life sciences. It is now possible use microfluidics organ‑on‑a‑chip techniques assess osteonecrosis. In present study, BMECs were cultured on a platform explore pathogenesis femoral‑head necrosis. The...
Abstract Background To assess the geometrical risk factors for meniscal injuries. We hypothesized that narrowness of intercondylar notch and smaller tibial spine could increase Methods retrospectively studied two hundred seven patients examined knee magnetic resonance images. Two experienced orthopedists evaluated severity The width, bicondylar width index, condyle femur, height, angle were measured in image slides by blinded orthopedists. Results A total 112 with a meniscus injury 95 as...
To explore the effect of icariin on early steroid-induced osteonecrosis femoral head in rabbits.Fifty mature New Zealand rabbits (weighing, 2.5-3.0 kg) were randomly divided into control group ( n=10), model n=20), and experimental n=20). The groups injected with lipopolysaccharide methylprednisolone to establish animal head. feeded solution once a day for 6 weeks since first injection methylprednisolone, whereas given normal saline at same time points. left heads removed after gross...
Abstract Background Brucellosis is a zoonotic infection transmitted from infected animals to humans, osteonecrosis of the femoral head (ONFH) devastating disease that affects patients’ life with pain, dysfunction walking and always lead total hip arthroplasty (THA). We presented case ONFH which was very likely due Brucella spp. Case presentation The patient 49 years-old male who herder living in Inner Mongolia, northern part China. He first showed recurrent fever then bilateral confirmed be...
To explore the clinical efficacy of focused extracorporeal shock wave therapy with centrifugal exercise in treatment greater trochanteric pain syndrome.From September 2017 to June 2019, 53 eligible cases syndrome were randomly divided into observation group (29 cases) and control (24 cases). In group, there 8 males 21 females, aged from 38 62 years old an average (49.96±6.39) old; course disease ranged 6 13 months (8.58±1.99) months;treated exercise. 5 19 39 (52.79±5.86) old;the 14...
Abstract Background: To evaluate the efficacy and safety of a new hip prosthetic system compared with control group.Methods: A total 140 patients (140 hips) who met inclusion criteria in three clinical institutions were selected. The main outcome to judge excellent good rate Harris score experimental group 5 years after operation, whether lower limit 95% confidence interval difference between two groups was greater than non-inferior threshold (the cutoff value was-10%). secondary comparison...
Background: This study examined the distribution of symptomatic knee osteoarthritis (SKOA) according to sociodemographic characteristics and its association with utilization healthcare service catastrophic health expenditure. It compared effect 14 common chronic diseases on usage spending.Methods: We used data from three waves (2011, 2015, 2018) China Health Retirement Longitudinal Study (CHARLS). Participants aged 45 over in 2011 were included this study. expenditure as index for...
Abstract Background To assess the geometrical risk factors for meniscal injuries. Our hypothesis was that narrowness of intercondylar notch and smaller tibial spine could increase Methods We retrospectively studied two hundred seven patients examined knee magnetic resonance images. The severity injuries evaluated by experienced orthopedists. width, bicondylar width index, condyle femur, height, angle were measured in image slides blinded Results In all patients, 112 with a meniscus injury 95...
Abstract Background: Glucocorticoid could induce injury and apoptosis of bone microvascular endothelial cells (BMECs) in the femoral head application icariin showed a protective effect. However, impact autocrine exosomes during these processes is still to be confirmed. Methods: Exosomes were extracted from BMECs treated with hydrocortisone or plus by super-speed centrifugation; exosome-carried proteins evaluated via BCA assay, Western blotting, protein array assay Elisa test, while miRNA...