A5078898549- DNA and Nucleic Acid Chemistry
- Force Microscopy Techniques and Applications
- Orbital Angular Momentum in Optics
- Nanopore and Nanochannel Transport Studies
- Near-Field Optical Microscopy
- RNA and protein synthesis mechanisms
- Quantum Electrodynamics and Casimir Effect
- Bacteriophages and microbial interactions
- Microfluidic and Bio-sensing Technologies
- Psychological Well-being and Life Satisfaction
- Molecular Junctions and Nanostructures
- Higher Education and Employability
- stochastic dynamics and bifurcation
- Advanced Thermodynamics and Statistical Mechanics
- DNA Repair Mechanisms
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Financial Literacy, Pension, Retirement Analysis
- Human Resource and Talent Management
- Technology Adoption and User Behaviour
- Blockchain Technology Applications and Security
- Advanced biosensing and bioanalysis techniques
- Diffusion and Search Dynamics
- Entrepreneurship Studies and Influences
Universidad San Pablo
2021
Universidad San Pablo CEU
2021
Madrid Institute for Advanced Studies
2018-2019
IMDEA Nanoscience
2018
Universitat de Barcelona
2009-2015
Instituto de Salud Carlos III
2009-2015
Pontifícia Universidade Católica do Rio Grande do Sul
2013
University of KwaZulu-Natal
2013
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2009
El presente estudio tiene por objeto explorar las soft skills que se encuentran más relacionadas con la capacidad para responder a actividades o tareas en el entorno de trabajo. La muestra está compuesta 530 trabajadores los cuales les evalúan 11 competencias distribuidas 24 dimensiones diferenciadas. Los resultados indican puede agrupar tres clústeres significativamente diferenciados, entre destacan especialmente puntuaciones uno ellos, siendo éste valorado organizaciones. Además, pone foco...
Molecular shuttles are the basis of some most advanced synthetic molecular machines. In these devices a macrocycle threaded onto linear component between different portions thread in response to external stimuli. Here, we use optical tweezers measure mechanics and dynamics individual aqueous conditions. Using DNA as handle single molecule reporter, thousands shuttling events determine force-dependent kinetic rates motion main parameters governing energy landscape system. Our findings could...
Genome replication induces the generation of large stretches single-stranded DNA (ssDNA) intermediates that are rapidly protected by DNA-binding (SSB) proteins. To date, mechanism which tightly bound SSBs removed from ssDNA lagging strand polymerase without compromising advance fork remains unresolved. Here, we aimed to address this question measuring, with optical tweezers, real-time kinetics human mitochondrial and bacteriophage T7 polymerases on free-ssDNA, in comparison covered...
A more sustainable society and economy also implies behavior in terms of the consumption financial products. possible change this can be brought about when there is a demand. In other words, products directly related to literacy. However, latter’s definition, object, scope are far from being agreed upon internationally. One objective work was explore different interpretations literacy academic literature. exploration we delved into evolution term, how, what context, with concepts term used...
A main goal of single-molecule experiments is to evaluate equilibrium free energy differences by applying fluctuation relations repeated work measurements along irreversible processes. We quantify the error that made in a estimate means Jarzynski equality when accumulated expended on whole system (including instrument) erroneously replaced transferred subsystem consisting sole molecular construct. find may be as large 100%, depending number and bandwidth data acquisition apparatus. Our...
Knowledge of the mechanisms interaction between self-aggregating peptides and nucleic acids or other polyanions is key to understanding many aggregation processes underlying several human diseases (e.g. Alzheimer's Parkinson's diseases). Determining affinity kinetic steps such interactions challenging due competition hydrophobic forces electrostatic binding forces. Kahalalide F (KF) an anticancer peptide which contains a single positive charge that confers strong aggregative properties with...
Stochastic resonance (SR) is a well-known phenomenon in dynamical systems. It consists of the amplification and optimization response system assisted by stochastic (random or probabilistic) noise. Here we carry out first experimental study SR single DNA hairpins which exhibit cooperatively transitions from folded to unfolded configurations under action an oscillating mechanical force applied with optical tweezers. By varying frequency oscillation, investigate folding unfolding kinetics...
A more sustainable society and economy also implies a behavior in the consumption of financial products. possible change focus can come from demand side, so that products have to go hand with literacy. However, literacy, potential favoring this behavior, is far reaching an international consensus about its definition, object scope. Two objectives are analyzed; different interpretations literacy academic literature, as well evolution how, what context other concepts term used social networks....
Optical trapping of individual particles is believed to be only effective under highly focused beams because these conditions strengthen the gradient forces. This especially critical in beam propagating direction, where scattering and absorption forces must counterbalanced. Here, we demonstrate that optical nanostructures also possible a weakly beam. We study theoretical for three-dimensional confinement verify them experimentally on iron-oxide-based nanoparticles with without silica...
TERRA is an RNA molecule transcribed from human subtelomeric regions toward chromosome ends potentially involved in regulation of heterochromatin stability, semiconservative replication, and telomerase inhibition, among others. contains tandem repeats the sequence GGGUUA, with a strong tendency to fold into four-stranded arrangement known as parallel G-quadruplex. Here, we demonstrate by using single-molecule force spectroscopy that this potential limited inherent capacity self-associate...
Force-spectroscopy experiments make it possible to characterize single ligand-receptor pairs. Here we measure the spectrum of bond strengths and flexibilities in antibody-antigen interactions using optical tweezers. We mechanical evolution polyclonal antibodies generated under infection ability a monoclonal antibody cross-react against different antigens. Our results suggest that flexibility plays major role remodeling bonds order improve recognition during maturation humoral immune system.