A5004631968- RNA Interference and Gene Delivery
- Advanced Materials and Mechanics
- Advanced Sensor and Energy Harvesting Materials
- Supercapacitor Materials and Fabrication
- Advanced biosensing and bioanalysis techniques
- Polymer Surface Interaction Studies
- Photonic Crystals and Applications
- Analytical Chemistry and Sensors
- Cellular Mechanics and Interactions
- Graphene and Nanomaterials Applications
- DNA and Nucleic Acid Chemistry
- Conducting polymers and applications
- Force Microscopy Techniques and Applications
- Advancements in Battery Materials
- Nanoparticles: synthesis and applications
- Aerogels and thermal insulation
- Connexins and lens biology
- Carbon Nanotubes in Composites
- Microfluidic and Bio-sensing Technologies
- Plant and Fungal Species Descriptions
- Graphene research and applications
- Electrochemical sensors and biosensors
- Iron oxide chemistry and applications
- Nuclear Structure and Function
- Polydiacetylene-based materials and applications
University of Chicago
2024-2025
Emory University
2019-2023
Shanxi University
2023
Wuhan University of Technology
2014-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Tianjin University of Traditional Chinese Medicine
2019
Materials Science & Engineering
2017
University College Dublin
2014
<italic>In situ</italic> N-doped mesoporous carbon nanofibers synthesized by depositing magnesium hydroxide (Mg(OH)<sub>2</sub>) into polyacrylonitrile (PAN) and combining carbonization with etching process exhibit excellent supercapacitive performance.
Stimuli-responsive color-changing hydrogels, commonly colored using embedded photonic crystals (PCs), have potential applications ranging from chemical sensing to camouflage and anti-counterfeiting. A major limitation in these PC hydrogels is that they require significant deformation (>20%) order change the lattice constant generate an observable chromatic shift (∼100 nm). By analyzing mechanism of how chameleon skin changes color, we developed a strain-accommodating smart (SASS), which...
Art work conducted in normal glass containers: an alternative facile method for state-of-the-art magnetite nanocrystal clusters have been introduced.
Cells sense and respond to the physical properties of their environment through receptor-mediated signaling, a process known as mechanotransduction, which can modulate critical cellular functions such proliferation, differentiation, survival. At molecular level, cell adhesion receptors, integrins, transmit piconewton (pN)-scale forces extracellular matrix, magnitude force plays role in signaling. The most sensitive approach measuring integrin involves DNA hairpin-based sensors, are used...
Abstract Self‐destructive polymers (SDPs) are defined as a class of smart that autonomously degrade upon experiencing an external trigger, such chemical cue or optical excitation. Because SDPs release the materials trapped inside network degradation, they have potential applications in drug delivery and analytical sensing. However, no known respond to mechanical forces been reported, it is fundamentally challenging create mechano‐sensitivity general especially so for force levels below those...
Cardiac muscle cells (CMCs) are the unit that comprise heart. CMCs go through different stages of differentiation and maturation pathways to fully mature into beating cells. These can sense respond mechanical cues receptors such as integrins which influence pathways. For example, cell traction forces important for development functional CMCs, cultured on varying substrate stiffness function differently. Most work in this area has focused understanding role bulk extracellular matrix mediating...
An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed Michael addition. The degradation of polymer strongly pH-dependent. High nucleic transfection efficiency low cytotoxicity observed compared to its non-degradable counterpart.
Hydrogels embedded with periodic arrays of nanoparticles display a striking photonic crystal coloration that may be useful for applications such as camouflage, anticounterfeiting, and chemical sensing. Dynamically generating color patterns requires control nanoparticle organization within polymer network on-demand, which is challenging. We solve this problem by creating DNA hydrogel system shows 50 000-fold decrease in modulus upon heating ∼10 °C. Magnetic entrapped these gels generate...
For most stimuli‐responsive polymer materials (SRPMs), such as gels, micelles, and brushes, the responsive mechanism is based on solubility or compatibility with liquid media. That basis always results in distorting collapsing material's appearance relies external liquids. Here, a novel kind of SRPMs proposed. Unlike SRPMs, stored within special domains rather than expelled, so it deforming‐free relying no liquid, which referred to self‐storage (SS‐SRPMs). The facile universal route...
Cells exist in the body mechanically dynamic environments, yet vast majority of vitro cell culture is conducted on static materials such as plastic dishes and gels. To address this limitation, we report an approach to transition widely used hydrogels into active substrates by doping optomechanical actuator (OMA) nanoparticles within polymer matrix. OMAs are composed gold nanorods surrounded a thermoresponsive shell that rapidly collapses upon near-infrared (NIR) illumination. As proof...
Therapeutic nucleic acids represent a powerful class of drug molecules to control gene expression and protein synthesis. A major challenge in this field is that soluble oligonucleotides have limited serum stability, the majority enter cells are trapped within endosomes. Delivery efficiency can be improved using lipid scaffolds. One such example nanodisc (ND), self-assembled nanostructure composed phospholipids peptides modeled after high density lipoproteins (HDLs). Herein, we describe...
Delivery of nucleic acids can be hindered by multiple factors including nuclease susceptibility, endosome trapping, and clearance. Multiple nanotechnology scaffolds have offered promising solutions, among these, lipid-based systems are advantageous because their high biocompatibility low toxicity. However, many lipid nanoparticle still issues regarding stability, rapid clearance, cargo leakage. Herein, we demonstrate the use a synthetic nanodisc (ND) scaffold functionalized with an...
A novel branched amphiphilic macromolecule on the basis of a sensitive Si–O–C structure was synthesized through one-pot procedure. The self-assembly behavior molecule tunable in non-aq...
Highly dispersible nanoparticles in organic solvent always receive wide interests due to their compatibility with polymer materials. This paper reported a kind of isopropanol alcohol silica dispersion which obtained using method azeotropic distillation. The dispersed (IPADS) were treated coupling agents fine-tune surface properties. Polymethyl methacrylate (PMMA) was then used as research object test the between IPADS and polymer. UV-vis spectra indicate that would reach its high PMMA if...