A5002321274- SARS-CoV-2 and COVID-19 Research
- RNA and protein synthesis mechanisms
- Cell death mechanisms and regulation
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Influenza Virus Research Studies
- Lipid Membrane Structure and Behavior
- Computational Drug Discovery Methods
Universitat de València
2022-2023
Several methods have been developed to explore interactions among water-soluble proteins or regions of proteins. However, techniques target transmembrane domains (TMDs) not examined thoroughly despite their importance. Here, we a computational approach design sequences that specifically modulate protein–protein in the membrane. To illustrate this method, demonstrated BclxL can interact with other members B cell lymphoma 2 (Bcl2) family through TMD and these are required for control death....
Abstract Several methods have been developed to explore interactions among water-soluble proteins or regions of proteins. However, techniques target transmembrane domains not examined thoroughly. Here we a novel computational approach design sequences that specifically modulate protein-protein in the membrane. To illustrate this method demonstrated BclxL can interact with other members Bcl2 family through domain and these are necessary for control cell death. Next, designed recognize...
Abstract Several approaches have been developed to analyze the entry of highly pathogenic viruses. In this study, we report implementation a Bimolecular Multicellular Complementation (BiMuC) assay safely and efficiently monitor SARS-CoV-2 S-mediated membrane fusion without need for microscopy-based equipment. Using BiMuC, screened library approved drugs identified compounds that enhance S protein-mediated cell-cell fusion. Among them, ethynylestradiol promotes growth Influenza A virus in...
Abstract The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the pandemic disease known as coronavirus 2019 (COVID-19). COVID-19 vaccines were developed at record speed and authorized approximately a year after original outbreak. This fast response saved lives of countless individuals reduced burden many more. experience served reminder necessity to implement solid vaccine development platforms production pipelines. Manufacturing for enveloped viruses, including...