A5040966447- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Biochemical and Molecular Research
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Cancer, Hypoxia, and Metabolism
- Crystallography and molecular interactions
- Liver Disease Diagnosis and Treatment
- Catalytic C–H Functionalization Methods
- Cytomegalovirus and herpesvirus research
- Fluorine in Organic Chemistry
- Monoclonal and Polyclonal Antibodies Research
- Hemoglobin structure and function
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Renal Transplantation Outcomes and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Immunotherapy and Immune Responses
- 14-3-3 protein interactions
- Cancer Research and Treatments
- Cancer Treatment and Pharmacology
- Chromatography in Natural Products
- Redox biology and oxidative stress
Ollscoil na Gaillimhe – University of Galway
2015-2021
Santa Clara University
1989
Eli Lilly (United States)
1968-1975
United States Department of the Army
1965
National Cancer Institute
1963
Indiana University School of Medicine
1963
Indiana University – Purdue University Indianapolis
1963
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-activity relationships of dimeric Catharanthus alkaloids. 1. Deacetyl vinblastine amide (vindesine) sulfateCharles J. Barnett, George Cullinan, Koert Gerzon, Richard C. Hoying, William E. Jones, M. Newlon, Gerald A. Poore, Robert L. Robison, Martin Sweeney, and Cite this: Med. Chem. 1978, 21, 1, 88–96Publication Date (Print):January 1978Publication History Published online1 May 2002Published inissue 1 January...
A new series of selectively dichlorinated and dibrominated five- to eight-membered-ring [1,2-a]-fused benzimidazoles [1,4]oxazino[4,3-a]benzimidazoles are synthesized in mostly high yields >80% using the reaction hydrogen peroxide hydrohalic acid with commercially available o-cyclic amine substituted anilines. Domestic bleach HCl can also be used for a one-pot ring closure chlorination.
3,6-Dimethoxy-2-(cycloamino)anilines undergo 4- or 6-electron oxidations to afford novel ring-fused halogenated benzimidazoles benzimidazolequinones using H2O2/HCl H2O2/HBr. Cl2 and Br2 are capable of the same oxidative transformation benzimidazolequinones. Labeling experiments indicate that water is necessary for oxidation para-dimethoxybenzenes corresponding quinones.
Cell viability studies for benzo[1,2,4]triazin-7-ones and 1,2,4-benzotriazinyl (Blatter-type) radical precursors are described with comparisons made 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO). All of the stable free radicals were several orders magnitude less cytotoxic than benzo[1,2,4]triazin-7-ones. The synthesis evaluation two new pyrid-2-yl described, where altering 1,3-substitution from phenyl to increased cytotoxicity against most cancer cell lines, as indicated using National Cancer...