A5011922525- Cholinesterase and Neurodegenerative Diseases
- Botany and Plant Ecology Studies
- Plant nutrient uptake and metabolism
- Plant responses to elevated CO2
- Lichen and fungal ecology
- Pesticide Exposure and Toxicity
- Nicotinic Acetylcholine Receptors Study
- Mycorrhizal Fungi and Plant Interactions
- Computational Drug Discovery Methods
- Microbial Community Ecology and Physiology
- Lipid metabolism and biosynthesis
- Advanced Proteomics Techniques and Applications
University of Iceland
2016-2022
The University of Sydney
2020
Plants are constantly challenged in their natural environment by a range of changing conditions. We investigated the acclimation processes and adaptive plant responses to various long-term mild changes compared them directly within one experimental set-up. Arabidopsis thaliana plants were grown hydroponic culture for 10 d under controlled abiotic stress (15°C, 25°C, salt osmotic) nutrient deficiency (nitrate phosphate). Plant growth was monitored proteomic experiments performed. Resource...
Despite extensive efforts in the development of drugs for complex neurodegenerative diseases, treatment often remains challenging or ineffective, and hence new strategies are necessary. One approach is design multi-target drugs, which can potentially address nature disorders such as Alzheimer’s disease. We report a method high throughput virtual screening aimed at identifying dual target hit molecules. identified hits,...
Club mosses are plants belonging to the family of Lycopodiaceae. They produce lycopodium alkaloids with compact, stable structures considerable pharmacological interest [1,2]. can interfere important neurological targets for Alzheimer's and other neurodegenerative diseases have favorable properties [2]. Lycodane-type such as huperzine A B, known be potent acetylcholinesterase (AChE) inhibitors Another alkaloid, annotine, is a lycopodane-type alkaloid found exclusively in Lycopodium annotinum...