A5044715627- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Cancer-related molecular mechanisms research
- Medicinal Plants and Bioactive Compounds
- Biochemical effects in animals
- Lipid metabolism and disorders
- RNA regulation and disease
- Neuropeptides and Animal Physiology
- Caveolin-1 and cellular processes
- Biochemical Acid Research Studies
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Transcranial Magnetic Stimulation Studies
- Chemical Synthesis and Analysis
- Dementia and Cognitive Impairment Research
- Connexins and lens biology
- Barrier Structure and Function Studies
- Paraoxonase enzyme and polymorphisms
- Attention Deficit Hyperactivity Disorder
- Ion Channels and Receptors
Ruijin Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
The University of Texas Southwestern Medical Center
2011-2016
Southwestern Medical Center
2014
Mushroom dendritic spine structures are essential for memory storage and the loss of mushroom spines may explain defects in aging Alzheimer's disease (AD). The stability depends on stromal interaction molecule 2 (STIM2)-mediated neuronal-store-operated Ca 2+ influx (nSOC) pathway, which is compromised AD mouse models, neurons, sporadic patients. Here, we demonstrate that Transient Receptor Potential Canonical 6 (TRPC6) Orai2 channels form a STIM2-regulated nSOC channel complex hippocampal...
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by deposits of aggregated amyloid-β (Aβ) peptide and neurofibrillary tangles in the brain parenchyma. Despite considerable research to elucidate pathological mechanisms identify therapeutic strategies for AD, effective treatments are still lacking. In present study, we found that salidroside (Sal), phenylpropanoid glycoside isolated from Rhodiola rosea L., can protect against Aβ-induced neurotoxicity four...
Dysregulated endoplasmic reticulum (ER) calcium (Ca2+) signaling is reported to play an important role in Alzheimer disease (AD) pathogenesis. The of ER Ca2+ release channels, the ryanodine receptors (RyanRs), has been extensively studied AD models and RyanR expression activity are upregulated brains various familial (FAD) models. objective this study was utilize a genetic approach evaluate importance type 3 (RyanR3) context pathology.
Alzheimer's disease (AD) and aging result in impaired ability to store memories, but the cellular mechanisms responsible for these defects are poorly understood. Presenilin 1 (PS1) mutations many early-onset familial AD (FAD) case
Behavioral changes or neuropsychiatric symptoms (NPSs) are common features in dementia and associated with accelerated cognitive impairment earlier deaths. However, how NPSs intertwined decline remains elusive. In this study, we identify that the basolateral amygdala (BLA) is a key brain region mood disorders memory AD course. During process from pre- to post-onset AD, dysfunction of parvalbumin (PV) interneurons pyramidal neurons leads hyperactivity basal state insensitivity external...
The quiescence of radial neural stem cells (rNSCs) in adult brain is regulated by environmental stimuli. However, little known about how the neurogenic niche couples external signal to regulate activation and transition quiescent rNSCs. Here, we reveal that long-term excitation hippocampal dentate granule (GCs) upon voluntary running leads rNSCs subgranular zone thereby generation newborn neurons. Unexpectedly, role these excited GC neurons NSCs depends on direct GC-rNSC interaction local...
Alzheimer's disease (AD) is an age-related and progressive neurodegenerative that causes substantial public health care burdens. Intensive efforts have been made to find effective safe treatment against AD. Salidroside (Sal) the main component of Rhodiola rosea L., which has several pharmacological activities. The objective this study was investigate efficacy Sal in AD transgenic Drosophila associated mechanisms.We used tau line (TAU) protein expressed central nervous system eyes by Gal4/UAS...
Mushroom spine loss and calcium dyshomeostasis are early hallmark events of age-related neurodegeneration, such as Alzheimer's disease (AD), that connected with neuronal hyperactivity in pathology cognitive brain areas. However, it remains elusive how these key triggered at the molecular level for abnormality occurs initial stage disease. Here, we identify downregulated miR-339-5p its upregulated target protein, neuronatin (Nnat), cortex neurons from presenilin-1 M146V knockin (PSEN1-M146V...
Alzheimer's disease (AD) is the most common form of dementia and currently affects 5.4 million Americans. A number anti-Aβ (beta amyloid) therapeutic agents have been developed for AD, but so far all them failed in clinic. Here we used peptoid chemistry to develop ligands selective Aβ42. Peptoids are N-substituted glycine oligomers, a class peptidomimics. We synthesized an on-bead library consisting 38,416 unique peptoids. The generated was screened arrays Aβ42-selective were identified. One...
CSF1R-related leukoencephalopathy, also known as hereditary diffuse leukoencephalopathy with spheroids (HDLS), is a rare white-matter encephalopathy characterized by motor and neuropsychiatric symptoms due to colony-stimulating factor 1 receptor (CSF1R) gene mutation. Few of CSF1R mutations have been functionally testified the pathogenesis remains unknown.In order investigate clinical pathological characteristics patients explore potential impact mutations, we analyzed manifestations 15 from...
Abstract Innate emotion response to environmental stimuli is a fundamental brain function that controlled by specific neural circuits. Dysfunction of early emotional circuits may lead neurodevelopmental disorders such as autism and schizophrenia. However, how the functional are formed prime initial behaviours remain elusive. We reveal here using gene-targeted mutations an essential role for ephrin-B3 ligand-like activity in development innate fear neonatal brain. further demonstrate controls...
Abstract Background Neuropsychiatric symptoms (NPS) such as depression, anxiety, apathy, and irritability occur in prodromal phases of clinical Alzheimer’s disease (AD), which might be an increased risk for later developing AD. Here we treated young APP/PS1 AD model mice prophylactically with serotonin-selective re-uptake inhibitor (SSRI) paroxetine investigated the protective role anti-depressant agent emotional abnormalities cognitive defects during progress. Methods To investigate...
Oligodendrocytes have robust regenerative ability and are key players in remyelination during physiological pathophysiological states. However, the mechanisms of brain microenvironmental cue regulation differentiation oligodendrocytes still needs to be further investigated.We demonstrated that myelin-associated glycoprotein (MAG) was a novel receptor for angiopoietin-like protein 2 (ANGPTL2). The binding ANGPTL2 MAG efficiently promoted vitro, as evaluated an HCN cell line. Angptl2-null mice...
Abstract Social interaction and communication are evolutionary conserved behaviours that developed in mammals to establish partner cognition. Deficit sociability has been represented human patients animal models of neurodevelopmental disorders, which connected with genetic variants synaptic glutamate receptors associated PDZ-binding proteins. However, it remains elusive how these key proteins specialized the cellular level for initial social behaviour during postnatal developmental stage....
Abstract Social isolation in adolescence leads to lasting deficits, including emotional and cognitive dysregulation. It remains unclear, however, how social affects certain processes of memory what molecular mechanisms are involved. In this study, we found that during the post-weaning period resulted forgetting long-term fear memory, which was attributable downregulation synaptic function hippocampal CA1 region mediated by EphB2, a receptor tyrosine kinase involves glutamate multiprotein...
Social behavior starts with dynamic approach prior to the final consummation. The flexible processes ensure mutual feedback across social brains transmit signals. However, how brain responds initial stimuli precisely elicit timed behaviors remains elusive. Here, by using real-time calcium recording, we identify abnormalities of EphB2 mutant autism-associated Q858X mutation in processing long-range and accurate activity prefrontal cortex (dmPFC). EphB2-dependent dmPFC activation precedes...
Abstract Regulation and dysregulation of AMPA receptor (AMPAR) diffusional trapping at synapses are critical for synaptic efficacy implicated in various neurological neuropsychiatric disorders. However, the limited availability reliable tools to modulate this process hinders our ability explore its role both physiological conditions disease, as well drug development. In study, we designed characterized a 21-amino-acid trans-activator transcription (TAT)-fused peptide that mimics binding...
Abstract Introduction Alzheimer's disease (AD) is an age‐related neurodegenerative disorder. One of the pathological features AD neuronal loss in brain regions associated with cognition, particularly hippocampus. An enriched environment (EE) can facilitate plasticity and improve behaviors such as emotion, motor function, cognition AD. Methods After APP/PS1 mice were exposed to EE at early stage (2 months age), elevated plus maze performance contextual fear conditioning tested, neurogenesis...