A5084654632- RNA Interference and Gene Delivery
- Bacteriophages and microbial interactions
- Salmonella and Campylobacter epidemiology
- Origins and Evolution of Life
- Nanoplatforms for cancer theranostics
- Molecular Communication and Nanonetworks
- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Cancer Research and Treatments
- Graphene and Nanomaterials Applications
- PI3K/AKT/mTOR signaling in cancer
- Nanotechnology research and applications
- Virus-based gene therapy research
- Sphingolipid Metabolism and Signaling
- Biochemical and Structural Characterization
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Nanoparticles: synthesis and applications
- Antibiotic Resistance in Bacteria
- Natural Compounds in Disease Treatment
- CAR-T cell therapy research
University of California, Irvine
2014-2021
Extracellular vesicles (EVs) pose great promise as therapeutic carriers due to their ideal size range and intrinsic biocompatibility. Limited scalability, poor quality control during production, cumbersome isolation purification processes have caused major setbacks in the progression of EV therapeutics clinic. Here, we overcome these by preparing cell-derived nanovesicles induced sulfhydryl-blocking (NIbS), desirable for delivery, that can be further loaded with chemotherapeutic drug,...
Despite its promises for biomedical applications, the lack of solubility in a physiological solution, limited molecular interactions with nucleic acids due to rigid backbone, and inefficient intracellular release limit use chitosan, natural cationic polysaccharide, gene delivery. In this study, flexible, aqueous-soluble aminoethoxy branch was conjugated primary hydroxyl group chitosan via an acid-cleavable ketal linkage, resulting acid-transforming (ATC) greatly increased aqueous solubility,...
Single modal cancer therapy that targets one pathological pathway often turns out to be inefficient. For example, relapse of chronic myelogenous leukemia (CML) after inhibiting BCR-ABL fusion protein using tyrosine kinase inhibitors (TKI) (e.g., Imatinib) is significant clinical concern. This study developed a dual gene simultaneously tackles two key BCR-ABL-linked pathways viral/nonviral chimeric nanoparticles (ChNPs). Consisting an adeno-associated virus (AAV) core and acid-degradable...
Targeting the inability of cancerous cells to adapt metabolic stress is a promising alternative conventional cancer chemotherapy. FTY720 (Gilenya), an FDA-approved drug for treatment multiple sclerosis, has recently been shown inhibit progression through down-regulation essential nutrient transport proteins, selectively starving death. However, clinical use therapy prohibited because its capability inducing immunosuppression (lymphopenia) and bradycardia when phosphorylated upon...
Abstract Antibiotics are highly successful against microbial infections. However, current challenges include rising antibiotic resistance rates and limited efficacy intracellular pathogens. A novel form of a nanomaterial‐based antimicrobial agent is investigated for efficient treatment an Salmonella enterica sv Typhimurium infection. known polysaccharide, chitosan, engineered to be readily soluble under neutral aqueous conditions systemic administration. The modified biologic, named...
Front Cover: Nanocomplexes of acid-transforming chitosan (ATC) and DNA fragments are endocytosed to Salmonella Typhimurium-infected macrophages. The mildly acidic environment in the phagolysosome converts ATC an antimicrobial which is subsequently released from nanocomplexes effectively eradicates S. Typhimurium both cytoplasm via tackling a broad range key microbial proteins. This reported by Young Jik Kwon co-workers article number 2000408.