A5036225081- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Biosensors and Analytical Detection
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Luminescence Properties of Advanced Materials
- Electrochemical sensors and biosensors
- Force Microscopy Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Molecular Junctions and Nanostructures
- Nanocluster Synthesis and Applications
- MicroRNA in disease regulation
- Carbon and Quantum Dots Applications
- Perovskite Materials and Applications
- Nanopore and Nanochannel Transport Studies
- Lanthanide and Transition Metal Complexes
- Alzheimer's disease research and treatments
- Solid State Laser Technologies
- Vehicle Noise and Vibration Control
- Molecular Sensors and Ion Detection
- Electrochemical Analysis and Applications
- Neuroscience and Music Perception
- Microwave Dielectric Ceramics Synthesis
- Graph theory and applications
- Lipid Membrane Structure and Behavior
State Key Laboratory of Chemobiosensing and Chemometrics
2018-2024
Hunan University
2018-2024
Sun Yat-sen University
2022-2023
Changsha University
2020
Ritsumeikan University
2019
Northeastern University
2019
Liaoning Water Conservancy Society
2019
Alkaline phosphatase (ALP) is a significant biomarker in clinical diagnostics, and the abnormal level of ALP enzyme serum closely related to various diseases such as bone or liver cancer, metastases, extrahepatic biliary obstruction. Herein simple portable photothermal biosensor was developed for sensitive detection based on formation polydopamine (PDA) nanoparticles using thermometer temperature discoloration sticker readout. A MnO2 nanosheet first prepared novel one-pot strategy which...
Antifouling surfaces that could reduce nonspecific adsorption from a complex matrix are great challenge in surface plasmon resonance (SPR) sensors. An antifouling made by the covalent attachment of DNA tetrahedron probes (DTPs) onto gold demonstrated superior property against protein and cell. DTP-modified Au (DTPs–Au) film for two single samples (1 mg/mL myoglobin, 48 HSA) five matrices (100% serum, 100% plasma, 9.85 × 108 red cells/mL, 5% whole blood, cell lysate) had low or ultralow...
An unusual concentration quenching effect is caused by the anisotropic distribution of centers in GdGaTi 2 O 7 :Eu 3+ .
Conventional imaging ellipsometry-based biosensing faces the challenges of poor sensitivity and narrow dynamic range, especially for some small molecules such as microRNA. Given that detection various exosomal miRNAs with tunable range could provide high-precision disease information improve accuracy diagnosis, a sensitive ellipsometry sensor was introduced to by terminus-regulated DNA hydrogelation. Tetrahedron probes complementary sequence target miRNA were used biorecognition elements...
Combined detection of multiple markers related to the same disease could improve accuracy diagnosis. However, abundance levels varied widely in real samples, making it difficult for traditional method meet requirements a wide range. Herein, three kinds cardiac biomarkers, troponin I (cTnI), myoglobin (Myo), and C-reaction protein (CRP), which were from pM level μM selected as model targets. Valency-controlled signal probes based on DNA tetrahedron nanostructures (DTNs) platinum nanoparticles...
Developing a strategy of modulating β-amyloid (Aβ) aggregation with low cost, easy synthesis, high efficiency, and biosafety is significant challenge for Alzheimer's disease (AD) therapy. Herein, DNA aptamer (Aβ-Apt) against Aβ42 obtained by in vitro selection was developed as potent inhibitor the first time. Indeed, monomer fibrillation inhibited completely Aβ-Apt. Notably, inhibition effect Aβ-Apt on oligomer more obvious than that aggregation. It presumed distinguishing may be attributed...
The mechanism of HSA@PDA/Fe nanocomposites' enhanced nanozyme activity was proposed and it developed for the detection H<sub>2</sub>O<sub>2</sub>.
The effects of electric field (EF) on amyloid proteins have been given increasing attention in regulation amyloid-β (Aβ) aggregation and therapeutic methods because prevalence Alzheimer's disease. Herein, for the first time, aptamer was used as a tool investigating EF Aβ40 monomer aggregates (Aβ40 oligomer fibril) by single-molecule force spectroscopy. Interestingly, had different aggregates, which might be due to interactions with EF-treated aggregates. With application oligomer, specific...
Batting training practice aims at increasing the batting performance of baseball players. Traditional methods have been proven effective in players real games. However, feedback player gets is limited to: vibration bat, sound impact and ball trajectory. We propose a Virtual Reality-based (VR) system that provides batters with instantaneous bat swing information as feedback. This includes: exact bat-ball location angle, replay for timing speed. The ability to review this immediately after...
The real application of DNA-functionalized gold nanoparticles (DNA-Au NPs) was limited by decreased stability and irreversible aggregation in high-ionic strength solutions complex systems. Therefore, exploring a kind DNA-Au NPs with excellent systems is challenging significant. Herein, novel universal bioconjugate strategy for constructing ultrastable designed based on the combination polydopamine (PDA) shell DNA linker. obtained DNA-linked Au@polydopamine (DNA-Au@PDA showed colloidal...
Given that a split aptamer provides chance for the development of sandwich assay targets with only one aptamer, it has received extensive attention in biosensing. However, due to lack binding mechanisms and reliable methods, there were still few aptamers bind proteins. In this work, cardiac biomarker myoglobin (Myo) was selected as model, new strategy engineering explored atomic force spectroscopy (AFM), against target protein could be achieved by choosing optimal probability between target....
Although fluorescent polydopamine nanoparticles (F-PDA NPs) have shown great promise in a variety of fields, there are still some challenges involved with their application, such as low quantum yields, stability, and dispersion. Herein, the effects synthesis conditions different sequences DNA on fluorescence intensity F-PDA NPs were systematically investigated. The results demonstrated that DNA-mediated displayed excellent stability Specifically, polycytosine (poly-C) improved NPs, an...
Abstract Understanding the binding of split aptamer/its target could become a breakthrough in application aptamer. Herein, vascular endothelial growth factor (VEGF), major biomarker human diseases, was used as model, and its interaction with aptamer explored single molecule force spectroscopy (SMFS). SMFS demonstrated that aptamer/VEGF 165 169.44 ± 6.59 pN at loading rate 35.2 nN/s, probability dependent on concentration VEGF . On basis dynamic results, one activation barrier dissociation...
With the rapid economic development, increase in motor vehicle holdings, a sharp urban road traffic, traffic noise exposure is becoming increasingly serious. This paper focuses on impact of human brain. We collected sounds different sound pressure levels (SPLs), and recorded electroencephalograph (EEG) when subjects exposed under SPLs' noise. Using graphic theoretical-based EEG method, effects with SPLs functional connectivity brain networks were studied. time-frequency analysis, beta2 bands...
The red light emitting from phosphors activated with Eu3+ is of great significance for optimizing the comprehensive performances white light-emitting diodes (WLEDs) solid-state lighting. Herein, LuBa3(BO3)3:Eu3+ and LuBa3(BO3)3:Tb3+,Eu3+ are synthesized via high temperature reaction to investigate effects doping concentration co-doping Tb3+ on quality emission in host. Under excitation 392 nm light, dominant peak LuBa3(BO3)3:xEu3+ gradually shifts 593 610 when increased 0.02 0.10, host found...